Doxorubicin (DOX) plays an important part in lymphoma treatment. However, various side effects on normal tissues restrict its clinical use. Nanocarriers connected by Gly–Phe–Leu–Gly (GFLG) can be equipped with the advantages of nanoparticles (NP...
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https://www.riss.kr/link?id=A106037154
Ying Jiang (Nanjing University) ; Chaoyang Guan (Nanjing University) ; Xu Liu (Nanjing University) ; Yushan Wang (Nanjing University) ; Huaqin Zuo (Nanjing University) ; Tian Xia (Nanjing University) ; Peipei Xu (Nanjing University) ; Jian Ouyang (Nanjing University)
2019
English
KCI등재,SCOPUS,SCIE
학술저널
134-144(11쪽)
3
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Doxorubicin (DOX) plays an important part in lymphoma treatment. However, various side effects on normal tissues restrict its clinical use. Nanocarriers connected by Gly–Phe–Leu–Gly (GFLG) can be equipped with the advantages of nanoparticles (NP...
Doxorubicin (DOX) plays an important part in lymphoma treatment. However, various side effects on normal tissues restrict its clinical use. Nanocarriers connected by Gly–Phe–Leu–Gly (GFLG) can be equipped with the advantages of nanoparticles (NPs), their enhanced permeability and retention (EPR) effect, and surface modifiability. Nanocarriers can also be specifically enzymatically hydrolyzed by cathepsin (Cath) B, a kind of enzyme highly expressed in tumor cells. In this work, we proposed a novel drug delivery system comprising GFLG conjugated with copper sulfide (CuS) NPs loaded with DOX. The system, designated as CuS-GFLG-DOX, could be used for NP-based targeted combination chemotherapy. Results showed that the drug delivery system had an appropriate diameter, good dispersibility, high encapsulation efficiency and high drug loading. The system also exhibited an excellent targeting of lymphoma cells and an enhanced antitumor activity. The possible pathway to induce cytotoxic effects was Bcl-2/caspase-mediated apoptosis pathway. In conclusion, CuS-GFLG-DOX could precisely deliver drugs to lymphoma cells and could be a novel and promising therapeutic option for lymphoma.
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학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2021 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
2020-12-01 | 평가 | 등재 탈락 (해외등재 학술지 평가) | |
2013-10-01 | 평가 | 등재학술지 선정 (기타) | |
2008-01-01 | 평가 | SCIE 등재 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.63 | 0.14 | 0.51 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.45 | 0.39 | 0.176 | 0.05 |