안존이천탕 추출물이 흰쥐의 모체 및 태자에 미치는 영향 = The Toxicological Effects of Ahnjon-Yichun-Tang in Pregnant Rats and Fetuses

다국어 초록 (Multilingual Abstract)

The objective of this study was to characterize the adverse effects of Ahnjon-Yichun-Tang during early pregnancy. Following successful mating, female Sprague-Dawley rats were given Ahnjon-Yichun-Tang(AYT) extract by oral administration daily with dose of 150mg (n=10), 300mg(n=10), 450mg(n=10) for 20 days of pregnancy. The rats in Control group(n=10) were orally administrated with Saline. All pregnant rats of Ahnjon-Yichun-Tang-treated and Control groups were sacrificed on day 20 of pregnancy. The pregnancy outcome was determined and the internal and reproductive organs of pregnant rat were observed. The fetuses were examined for the presence of various developmental toxic endpoints and stained with alcian blue and alizarin red S, and observed skeletal malformations. The results obtained in this study represent that there is no significant changes between Control and Ahnjon-Yichun-Tang-treated groups in body weight, organ weight, blood chemistry values, hematological values and pregnancy indexes of pregnant rat. The skeletal malformation of fetus was not observed as well. These results suggest that oral administration of Ahnjon-Yichun-Tang does not produce either maternal or developmental toxicity.

참고문헌 (Reference)

1 한의부인과학교재편찬위원회, "한의부인과학 하" 도서출판 정담 97-100, 2001

2 윤영주, "한약이 간손상을 유발할 가능성이 있는가 : 한약 관련 간손상에 관한 국내 연구의 체계적 고찰" 경희대학교 동서의학대학원 2009

3 이은, "한약과 민간약물의 독성 및 부작용에 대한 고찰" 대한한방내과학회 23 (23): 222-227, 2002

4 식품의약품안전청, "의약품 등의 독성시험 기준 해설서"

5 한상백, "십전대보탕과 육미지황탕이 실험동물의 모체와 태자에 미치는 생식독성학적 연구" 상지대학교 대학원 2008

6 조현주, "습관성유산 치료 14례 임상보고" 대한한방부인과학회 18 (18): 159-168, 2005

7 전성진, "사물탕 용량별 투여가 랫드의 모체와 태자에 미치는 영향" 상지대학교 대학원 2009

8 한용주, "보중익기탕과 귀비탕 투여가 임신랫드의 모체 및 태자에 미치는 연구" 대한예방한의학회 14 (14): 91-104, 2010

9 박귀례, "방사선 조사 인삼이 랫드의 기형유발에 미치는 영향에 관한 연구" 17 (17): 27-32, 2001

10 김성란, "安尊二天湯을 中心으로 한 胎漏 및 胎動不安의 文獻的 考察" 13 : 609-624, 1998

11 이현희, "姙娠중 한약복용 환자에 관한 논문 23례 분석" 대한한방부인과학회 20 (20): 185-199, 2007

12 Eisenberg DM, "Trends in alternative medicine use in the United States, 1990-1997: results of a follow- up national survey" 280 (280): 1569-1575, 1998

13 Mapanga RF, "The renal effects of blood glucose-lowering plant- derived extracts in diabetes mellitus-an overview" 32 (32): 132-138, 2010

14 O’Halloran K, "The interaction of lead exposure and pregnancy" 6 (6): 35-39, 1992

15 Ozer J, "The current state of serum biomarkers of hepatotoxicity" 245 (245): 194-205, 2008

16 McCredie J, "Pathogenesis of congenital malformations" 135 (135): 293-297, 1978

17 Banfi G, "Metabolic markers in sports medicine" 56 : 1-54, 2012

18 Stedman C, "Herbal hepatotoxicity" 22 (22): 195-206, 2002

19 Westfall RE, "Herbal healing in pregnancy : women’s experiences" 3 (3): 17-39, 2003

20 Chen FP, "Frequency and pattern of Chinese herbal medicine pre- scriptions for chronic hepatitis in Taiwan" 117 (117): 84-91, 2008

21 Lyman JL, "Blood urea nitrogen and crea- tinine" 4 (4): 223-233, 1986

22 Niemela O, "Biomarkers of alcohol consumption and related liver disease" 70 (70): 305-312, 2010

23 Edelstein CL, "Biomarkers of acute kidney injury" 15 (15): 222-234, 2008

24 McRae CA, "Bass- endine MF. Hepatitis associated with Chinese herbs" 14 (14): 559-562, 2002

25 Fakeye TO, "Attitude and use of herbal medicines among pre- gnant women in Nigeria" 31 (31): 53-, 2009

26 Herlong HF, "Approach to the patient with abnormal liver enzymes" 29 (29): 32-38, 1994

27 Alexopoulos E, "Acute uric acid nephro- pathy in pregnancy" 3 (3): 488-489, 1992

28 Poole JH, "Acute renal failure in pregnancy" 24 (24): 66-72, 1999