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      Synthesis and biological evaluation of novel 2-pyridinyl-[1,2,3]triazoles as inhibitors of transforming growth factor β1 type 1 receptor

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      https://www.riss.kr/link?id=A76262590

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      다국어 초록 (Multilingual Abstract)

      A series of 2-pyridinyl-[1,2,3]triazoles have been synthesized and evaluated for their ALK5 inhibitory activity in the luciferase reporter assays. Compound 8d showed significant ALK5 inhibition (SBE-luciferase activity, 25%; p3TP-luciferase activity, 17%) at a concentration of 5μM that is comparable to that of SB-431542(SBE-luciferase activity, 21%, p3TP-luciferase activity, 12%). but weak p38α MAP kinase inhibition (13%) at a concentration of 10 μM that is much lower than that of SC-431542 (54%).
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      A series of 2-pyridinyl-[1,2,3]triazoles have been synthesized and evaluated for their ALK5 inhibitory activity in the luciferase reporter assays. Compound 8d showed significant ALK5 inhibition (SBE-luciferase activity, 25%; p3TP-luciferase activity, ...

      A series of 2-pyridinyl-[1,2,3]triazoles have been synthesized and evaluated for their ALK5 inhibitory activity in the luciferase reporter assays. Compound 8d showed significant ALK5 inhibition (SBE-luciferase activity, 25%; p3TP-luciferase activity, 17%) at a concentration of 5μM that is comparable to that of SB-431542(SBE-luciferase activity, 21%, p3TP-luciferase activity, 12%). but weak p38α MAP kinase inhibition (13%) at a concentration of 10 μM that is much lower than that of SC-431542 (54%).

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      목차 (Table of Contents)

      • Abstract
      • Acknowledgements
      • References and Notes
      • Abstract
      • Acknowledgements
      • References and Notes
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