Comparative Behavioral Correlation of High and Low-Performing Mice in the Forced Swim Test = Comparative Behavioral Correlation of High and Low-Performing Mice in the Forced Swim Test

다국어 초록 (Multilingual Abstract)

Behavioral analysis in mice provided important contributions in helping understand and treat numerous neurobehavioral and neuropsychiatric disorders. The behavioral performance of animals and humans is widely different among individuals but the neurobehavioral mechanism of the innate difference is seldom investigated. Many neurologic conditions share comorbid symptoms that may have common pathophysiology and therapeutic strategy. The forced swim test (FST) has been commonly used to evaluate the “antidepressant” properties of drugs yet the individual difference analysis of this test was left scantly investigated along with the possible connection among other behavioral domains. This study conducted an FST-screening in outbred CD-1 male mice and segregated them into three groups: high performers (HP) or the active swimmers, middle performers (MP), and low performers (LP) or floaters. After which, a series of behavioral experiments were performed to measure their behavioral responses in the open field, elevated plus maze, Y maze, three-chamber social assay, novel object recognition, delay discounting task, and cliff avoidance reaction. The behavioral tests battery revealed that the three groups displayed seemingly correlated differences in locomotor activity and novel object recognition but not in other behaviors. This study suggests that the HP group in FST has higher locomotor activity and novelty-seeking tendencies compared to the other groups. These results may have important implications in creating behavior database in animal models that could be used for predicting interconnections of various behavioral domains, which eventually helps to understand the neurobiological mechanism controlling the behaviors in individual subjects.

참고문헌 (Reference)

1 Mark G. Baxter, "“I've seen it all before”: Explaining age-related impairments in object recognition. Theoretical comment on Burke et al. (2010)." American Psychological Association (APA) 124 (124): 706-709, 2010

2 Crawley JN, "What’s Wrong with My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice" John Wiley & Sons 2007

3 Pellow S, "Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat" 14 : 149-167, 1985

4 Walf AA, "The use of the elevated plus maze as an assay of anxiety-related behavior in rodents" 2 : 322-328, 2007

5 Wermelinger Ávila MP, "The role of physical activity in the association between resilience and mental health in older adults" 26 : 248-253, 2018

6 Commons KG, "The rodent forced swim test measures stress-coping strategy, not depression-like behavior" 8 : 955-960, 2017

7 Prut L, "The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors : a review" 463 : 3-33, 2003

8 Can A, "The mouse forced swim test" (59) : 3638-, 2012

9 Stults-Kolehmainen MA, "The effects of stress on physical activity and exercise" 44 : 81-121, 2014

10 Kim KC, "The critical period of valproate exposure to induce autistic symptoms in Sprague–Dawley rats" 201 : 137-142, 2011

11 Gonzales ELT, "Supplementation of Korean Red Ginseng improves behavior deviations in animal models of autism" 60 : 29245-, 2016

12 Moy S, "Sociability and preference for social novelty in five inbred strains : an approach to assess autistic-like behavior in mice" 3 : 287-302, 2004

13 Verheij MM, "Rats that differentially respond to cocaine differ in their dopaminergic storage capacity of the nucleus accumbens" 105 : 2122-2133, 2008

14 Ennaceur A, "One-trial object recognition in rats and mice : methodological and theoretical issues" 215 : 244-254, 2010

15 Stedenfeld KA, "Novelty-seeking behavior predicts vulnerability in a rodent model of depression" 103 : 210-216, 2011

16 Jama A, "Inter-individual differences in novelty-seeking behavior in rats predict differential responses to desipramine in the forced swim test" 198 : 333-340, 2008

17 Pitychoutis PM, "Individual differences in novelty-seeking predict differential responses to chronic antidepressant treatment through sex-and phenotype-dependent neurochemical signatures" 223 : 154-168, 2011

18 dela Peña I, "Individual differences in novelty-seeking behavior in spontaneously hypertensive rats : Enhanced sensitivity to the reinforcing effect of methylphenidate in the high novelty-preferring subpopulation" 252 : 48-54, 2015

19 Hooks MS, "Individual differences in basal and cocaine-stimulated extracellular dopamine in the nucleus accumbens using quantitative microdialysis" 587 : 306-312, 1992

20 Chen X, "Impairment of oligodendroglia maturation leads to aberrantly increased cortical glutamate and anxiety-like behaviors in juvenile mice" 9 : 467-, 2015

21 Yoshida S, "Impairment of cliff avoidance reaction induced by subchronic methamphetamine administration and restraint stress : comparison between two inbred strains of rats" 22 : 1023-1032, 1998

22 National Research Council, "Guide for the Care and Use of Laboratory Animals" National Academies Press 2010

23 Petit-Demouliere B, "Forced swimming test in mice : a review of antidepressant activity" 177 : 245-255, 2005

24 Bogdanova OV, "Factors influencing behavior in the forced swim test" 118 : 227-239, 2013

25 Vogel-Ciernia A, "Examining object location and object recognition memory in mice" 69 : 8.31.1-8.31.17, 2014

26 Matta Ad, "Delay discounting : concepts and measures" 5 : 135-146, 2012

27 Rosenzweig MR, "Biological Psychology: an Introduction to Behavioral, Cognitive, and Clinical Neuroscience" Sinauer Associates 2002

28 Karl T, "Behavioral phenotyping of mice in pharmacological and toxicological research" 55 : 69-83, 2003

29 Lezak KR, "Behavioral methods to study anxiety in rodents" 19 : 181-, 2017

30 Stafstrom CE, "Behavioral and cognitive testing procedures in animal models of epilepsy In Models of Seizures and Epilepsy" Elsevier Inc 2006

31 Sarter M, "Attenuation of scopolamine-induced impairment of spontaneous alternation behaviour by antagonist but not inverse agonist and agonist β-carbolines" 94 : 491-495, 1988

32 Mitchell SH, "Assessing delay discounting in mice" 66 : 8-30, 2014

33 Cloninger CR, "A unified biosocial theory of personality and its role in the development of anxiety states" 3 : 167-226, 1986

34 Tanaka JW, "A neural basis for expert object recognition" 12 : 43-47, 2001

35 Wolf A, "A comprehensive behavioral test battery to assess learning and memory in 129S6/Tg2576 mice" 11 : e0147733-, 2016