Bilayered porous composite scaffolds for enhanced treatment of bone cancer through chemo-photothermal combination therapy

다국어 초록 (Multilingual Abstract)

The combination of therapeutic materials and biocompatible scaffolds to create multifunctional scaffolds with therapeutic and restorative functions has been investigated as a new therapeutic modality for bone cancers because the integration of multi-modal therapies into one platform can exhibit significant potential in overcoming the drawbacks of conventional therapy in bone cancers. In this study, we develop an IR780- and epigallocatechin gallate (EGCG)-loaded multifunctional polylactic acid (PLA) (E-PLMH780) composite scaffold for chemo-photothermal combination therapy without cytotoxicity. This bilayered E-PLMH780 scaffold is prepared using a layer of EGCG-loaded PLA monolith and a three-dimensionally printed PLA composite scaffold, followed by coating with IR780-loaded Mg-HA nanoparticles. The monolith layer in the composite scaffold exhibits a three-dimensional porous structure and a uniform morphology featuring small leaf-like units, whereas the three-dimensionally printed layer exhibits a uniform porous structure with a hierarchical architecture. The results of the chemo-photothermal combination therapy and cytotoxicity assays showed that the E-PLMH780 scaffold effectively inhibited bone cancer cell proliferation but did not cause cytotoxicity in normal osteoblastic cells. Therefore, chemo-photothermal combination therapy using IR780- and EGCG-loaded E-PLMH780 scaffolds can potentially provide a new generation of therapeutic modality for the improved treatment of bone cancers and repair of bone defects.

참고문헌 (Reference)

1 X. Xu, 13 : 100209-, 2022

2 S. Sritharan, 46 : 1361-1367, 2018

3 S. Chen, 213 : 112364-, 2022

4 A. Luetke, 40 : 523-532, 2014

5 Xiang Wei ; Peng Yongbo ; Zeng Hongliang ; Yu Chunping ; Zhang Qun ; Liu Biao ; Liu Jiahao ; Hu Xing ; Wei Wensu ; Deng Minhua ; Wang Ning ; Liu Xuewen ; Xie Jianfei ; Hou Weibin ; Tang Jin ; Long Zhi ; Wang Long ; Liu Jianye, 27 : 47-, 2023

6 Q. Yang, 8 : e10559-, 2023

7 G. Wan, 155 : 25-40, 2018

8 H. Ma, 13 : 4302-4311, 2019

9 L. Tong, 193 : 1-11, 2019

10 Q. Sun, 362 : 679-691, 2019

11 X. Wang, 19 : 2138-2147, 2019

12 Y. Pan, 24 : 100829-, 2022

13 B. Geng, 383 : 123102-, 2020

14 G. Wan, 15 : 25-40, 2018

15 L. Song, 238 : 109920-, 2022

16 L. Yang, 386 : 132812-, 2022

17 S. Hassanajili, 104 : 109960-, 2019

18 S. C. Suner, 71 : 103263-, 2022

19 J. Wu, 73 : 103482-, 2022

20 D. Veljovic, 45 : 22029-22039, 2019

21 D. Zheng, 311 : 131553-, 2022

22 Z. -S. Tao, 62 : 226-232, 2016

23 R. Scaffaro, 63 : 303-313, 2016

24 R. Baptista, 118 : 111528-, 2021

25 S. D. Ligon, 117 : 10212-10290, 2017

26 L. Tayebi, 84 : 148-158, 2018

27 T. Jin, 14 : 42-51, 2022

28 X. Ma, 8 : 1900661-, 2019

29 Y. Liu, 25 : 1353-1359, 2013

30 L. Ma, 36 : 48-62, 2020

31 M. Asadollahi, 27 : e00228-, 2022

32 L. Chang, 125 : 112098-, 2021

33 K. Chen, 182 : 1339-1350, 2021

34 F. Ding, 245 : 119976-, 2020

35 Y. Zhang, 278 : 121135-, 2021

36 J. Li, 7 : 44763-44778, 2016

37 S. Li, 9 : 22332-22341, 2017

38 M. Potara, 203 : 111755-, 2021

39 S. Wang, 330 : 483-492, 2021

40 W. Shao, 12 : 147-, 2020

41 W. Shao, 7 : 1379-1386, 2020

42 L. Yang, 10 : 2304190-, 2023

43 L. Yang, 476 : 146797-, 2023

44 J. Yuan, 15 : 100318-, 2022