1 McMahan, R.H, "Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte- directed in vitro cytotoxicity" 120 : 4546-4557, 2010
2 Mosmann, T.R, "The expanding universe of Tcell subsets: Th1, Th2 and more" 17 : 138-146, 1996
3 Gruener, N.H, "Sustained dysfunction of antiviral CD8+ T lymphocytes after infection with hepatitis C virus" 75 : 5550-5558, 2001
4 Betts, M.R, "Putative immunodominant human immunodeficiency virus-specific CD8(+) T-cell responses cannot be predicted by major histocompatibility complex class I haplotype" 74 : 9144-9151, 2000
5 Golden-Mason, L, "Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells" 83 : 9122-9130, 2009
6 Leroux-Roels, G, "Lymphoproliferative responses to hepatitis C virus core, E1, E2, and NS3 in patients with chronic hepatitis C infection treated with interferon alfa" 23 : 8-16, 1996
7 Spolski, R, "Interleukin-21: basic biology and implications for cancer and autoimmunity" 26 : 57-79, 2008
8 Gallimore, A, "Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes" 187 : 1383-1393, 1998
9 Fu, J, "Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients" 132 : 2328-2339, 2007
10 Wang, G, "In vivo antitumor activity of interleukin 21 mediated by natural killer cells" 63 : 9016-9022, 2003
1 McMahan, R.H, "Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte- directed in vitro cytotoxicity" 120 : 4546-4557, 2010
2 Mosmann, T.R, "The expanding universe of Tcell subsets: Th1, Th2 and more" 17 : 138-146, 1996
3 Gruener, N.H, "Sustained dysfunction of antiviral CD8+ T lymphocytes after infection with hepatitis C virus" 75 : 5550-5558, 2001
4 Betts, M.R, "Putative immunodominant human immunodeficiency virus-specific CD8(+) T-cell responses cannot be predicted by major histocompatibility complex class I haplotype" 74 : 9144-9151, 2000
5 Golden-Mason, L, "Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells" 83 : 9122-9130, 2009
6 Leroux-Roels, G, "Lymphoproliferative responses to hepatitis C virus core, E1, E2, and NS3 in patients with chronic hepatitis C infection treated with interferon alfa" 23 : 8-16, 1996
7 Spolski, R, "Interleukin-21: basic biology and implications for cancer and autoimmunity" 26 : 57-79, 2008
8 Gallimore, A, "Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes" 187 : 1383-1393, 1998
9 Fu, J, "Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients" 132 : 2328-2339, 2007
10 Wang, G, "In vivo antitumor activity of interleukin 21 mediated by natural killer cells" 63 : 9016-9022, 2003
11 Radziewicz, H, "Impaired hepatitis C virus (HCV)-specific effector CD8+ T cells undergo massive apoptosis in the peripheral blood during acute HCV infection and in the liver during the chronic phase of infection" 82 : 9808-9822, 2008
12 Wedemeyer, H, "Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection" 169 : 3447-3458, 2002
13 Elsaesser, H, "IL-21 is required to control chronic viral infection" 324 : 1569-1572, 2009
14 Publicover, J, "IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B" 121 : 1154-1162, 2011
15 Korn, T, "IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells" 448 : 484-487, 2007
16 Ill-Sup Nou, "Hepatitis C Virus Core Inhibits the Fas-mediated p38 Mitogen Activated Kinase Signaling Pathway in Hepatocytes" 한국분자세포생물학회 13 (13): 444-451, 2002
17 Shepard, C.W, "Global epidemiology of hepatitis C virus infection" 5 : 558-567, 2005
18 Fazilleau, N, "Follicular helper T cells: lineage and location" 30 : 324-335, 2009
19 Lavanchy, D., "Evolving epidemiology of hepatitis C virus" 17 : 107-115, 2011
20 Iannello, A, "Dynamics and consequences of IL-21 production in HIV-infected individuals: a longitudinal and cross-sectional study" 184 : 114-126, 2010
21 Sun, J.C, "Defective CD8 T cell memory following acute infection without CD4 T cell help" 300 : 339-342, 2003
22 Ou, R, "Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells" 75 : 8407-8423, 2001
23 Blackburn, S.D, "Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection" 10 : 29-37, 2009
24 Sun, J.C, "CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection" 5 : 927-933, 2004
25 Mehta, D.S, "Biology of IL- 21 and the IL-21 receptor" 202 : 84-95, 2004
26 Neumann-Haefelin, C, "Adaptive immune responses in hepatitis C virus infection" 369 : 243-262, 2013
27 Ozaki, K, "A critical role for IL-21 in regulating immunoglobulin production" 298 : 1630-1634, 2002