속방형 및 용출조절형 비타민 C 정제의 용출 특성 비교 분석

다국어 초록 (Multilingual Abstract)

In this study, a comparative dissolution experiment was conducted between an immediate-release and a controlled-release vitamin C tablet applied with a technology to control the dissolution of vitamin C to maintain the vitamin C level in the human body. In order to confirm the dissolution rate (%) of vitamin C tablets, HPLC determination was conducted based on the dissolution test methods in the ‘Korean Pharmacopoeia (No. 2020-88),’ ‘Guidelines on Specifications of Dissolution Tests for Oral dosage Forms,’ and ‘Standard and Specifications for Health Functional Foods (No. 2020-63)’ from Ministry of Food and Drug Safety (MFDS). In addition, the dissolution pattern between the immediate-release tablet and the controlled-release tablet was comparatively analyzed. The analysis result confirmed that the immediate-release vitamin C tablet was 100% dissolved after 45 minutes, while the controlled- release vitamin C tablet was 100% dissolved after 480 minutes (8 hours). Furthermore, the dissolution rate (%) at 60 minutes was slower than that of the immediate-release vitamin C tablet. Based on these results, this study confirmed that the dissolution rate (%) test and development of controlled-release tablets containing vitamin C as the main component a re possible.

목차 (Table of Contents)

• ABSTRACT
• Materials and methods
• 시약
• 용출조절 제품 제조
• 용출시험
• 비타민 C 정량시험
• 통계 처리
• Results and discussion
• 물리적 특성 및 비타민 C 함량
• 용출시험 결과
• 속방형과 용출조절형의 용출률 비교
• 국문요약
• Acknowledgement
• Conflict of interest
• ORCID
• References