Carbenoxolone sodium 이 흰쥐의 의액 및 위궤양 형성에 미치는 영향에 관한 실험적 연구 = An experimental study on the effects of carbenoxolone sodium on gastric secretion and gastric ulcer formation in rats

다국어 초록 (Multilingual Abstract)

This experimental study on the effects of carbenoxolone sodium(Bigastrone, Berk), which I.:, synthesized from glycyrrhetinic acid and di-sodium salt, was performed with the use of ulcer- induced Shay rats. The following results were obtained: (1j The ulcer index revealed the decrease in the carbenoxolone sodium group as compared with the control group indicating 21;8. (2) The amount of gastric secretion revealed rather increase in the carbenoxolone sodium group as compared with the control group indicating ll. 1+ 1. 6ml. (3) In determination of total acidity arid free Hcl of gastric juice, there could be demonstrated the marked decrease in the carbenoxolone sodium 200mg/kg administration as compared with the control group indicating 70. 615. GmEq/L and 38. 0+14. 2mEq/L. (4) In determination of total protein and mucoprotein, there could be seen the marked increase in the gastric juice of carbenoxolone sodium 200mg/kg group in comparision with 707.7+117. 4mg/dl of total protein and 230. 6+ 47. Smg/dl of mucoprotein in control group. (5) In result of electrophoresis on gastric juice of the rats, there could be demonstrated the three more fractions in comparision with serum electrophoresis. In fractionation of gastric juice electrophoresis of rats, we could be seen the decrease in the 1,2 and 3 fraction, but the marked . Increase in the 4 and 5 fraction indicating 14. 6Yoand 17. 1% and there could be demonstrate<I the striking P.A.S. staining. At last, there could be observed the marked effects on gastric ulcer suppression by carbenox- olone sodium administration as compared with the control group.