수종의 생약이 실험적 당뇨병에 미치는 영향 = Effects of Several Crude Drugs on Experimental Diabetes

다국어 초록 (Multilingual Abstract)

Streptozotocin(STZ; 40㎎/㎏ body wt.) was intraperitoneally administered to get hyperglycemic mice(blood glucose level, 290∼450㎎/dl) on 5 consecutive days. At day 7 after completion of low-dose streptozotocin treatment, the water extracts of crude drugs (Atractylodes Rhizoma, Aconiti Tuber, Anemarrhinae Rhizoma, Mori Radicis Cortex) were administered to the STZ-induced hyperglycemic mice for investigating the histopathologic changes of pancreatic islet.
At this stage, blood glucose level decreased significantly when crude drugs were administered to streptozotocin-induced hyperglycemic mice. The single administration of crude drug to hyperglycemic induced by with low-dose streptozotocin inhibited significantly a decreasing tendency of plasma contrast and pancreatic β-cell granules, disruption of plasma membrane, lymphocyte infiltration of islet β-cells, swelling and disruption of mitochondria compared with streptozotocin-induced hyperglycemic mice by electron microscopy. Whin the water extract of Atractylodes Thizoma was administered with insulin, it did not show actions besides insulin-secreting action. Intracellular Ca^2- concentration was significantly increased when the water extract of crude drug stimulated pancreatic β-cell isolated in normal rat with 10% glucose.
In this study, it was suggested that the water extracts of crude drugs showed hypoglycemic action because they promoted insulin- secreting action of pancreatic β-cell of STZ-induced hyperglycemic mice or rats by their β-cell stimulation.