현미부수체 불안정성과 암세포 침윤 조절 T세포를 이용한 위암의 예후 판정 = Prediction of gastric cancer prognosis using microsatellite instability and tumor infiltrating regulatory T lymphocytes

국문 초록 (Abstract)

MSI와 tumor infiltrating lymphocyte의 연관성을 이용하여 위암의 예후 판정을 하기 위한 연구였고 282 명의 환자를 대상으로 시행하는 것을 목표로 하였으나 현재 59명의 환자에서 일부 면역조직화학 염색이 시행되고 결과가 분석됨. 현재까지 밝혀진 결과를 요약하면 MSI-high type gastric cancer는 CD8+ lymphocyte의 침윤이 증가하였고 CD3+, CD4+ lymphocyte 의 침윤은 감소한 상태임. CD8+/CD3+ ratio가 굉장히 높아 MSI high type에서 생존율을 증가가 cytotoxic T lymphocyte의 침윤증가가 원인임을 추정할수 있었음.

다국어 초록 (Multilingual Abstract)

The purpose of this study was to identify the prognostic factor in gastric cancer patients using MSI and tumor infiltrating lymphocytes. The target number of case was 282 patients. Currently, we checked the immunohistochemical staining in 59 patients except for foxp3+ primary antibody. What we found were as follows. In MSI-high type gastric cancer, the number of infiltrating lymphocyte with CD8+ increased; CD4+ decreased; and CD8+/CD3+ ratio was high in MSI-High type gastric cancer. These findings imply that favorable prognosis in MSI-high type gastric cancer was associated with increased cytotoxic T lymphocyte activity. If immunostaining of regulatory T lymphocytes (Foxp3+) is identified and analyzed, survival analysis based on the MSI type and tumor infiltrating lymphocytes would be helpful to identify high-risk gastric cancer patients