히어리의 鎭痛 效能

다국어 초록 (Multilingual Abstract)

Abstract

Anti-nociceptive activity of Corylopsis gotoana


Park, Zi Won
Dept. of Oriental Pharmacy
College of Pharmacy
Graduate School of Woosuk University
(Directed by Prof. Jeon, Hoon, Ph.D.)

Corylopsis gotoana has been widely used as a traditional medicine for the treatment of lots of disease including cold, edema and vomiting. However pharmacological and phytochemical studies on the C. gotoana are extremely limited. Here in this study, the author investigated the anti-nociceptive effects of the methanolic extract of Corylopsis gotoana (MCG) using various pain models. In the present study, MCG exhibited strong and dose-dependent anti-nociceptive activities on various experimental pain models including thermal nociception and chemical nociception, compared to positive control such as tramadol and indomethacin. In addition, the result from combination test using naloxone, analgesic activity of MCG was slightly reduced, indicating that MCG acts as a partial opioid receptor agonist. These results demonstrated that MCG has potent analgesic potential and thus it may be possibly used as a valuable anti-nociceptive agent.

목차 (Table of Contents)

• Abstract ⅴ
• I. 서론 1
• II. 실험 및 방법 5
• 1. 실험재료 5
• 2. 시약 및 기구 5
• 3. 실험 동물 6
• 4. 급성 독성 실험 6
• 5. Tail immersion test 7
• 6. Hot-plate test 7
• 7. Acetic acid-induced writhing test 8
• 8. Formalin test 9
• 9. 통계분석 10
• III. 실험결과 11
• 1. 히어리의 급성 독성 11
• 2. Tail immersion test에서의 히어리의 진통 효능 12
• 3. Hot-plate test에서의 히어리의 진통 효능 14
• 4. Acetic acid test에서의 히어리의 진통 효능 16
• 5. Formalin test에서의 히어리의 진통 효능 18
• IV. 고찰 20
• V. 결론 24
• 참고문헌 25