세신으로부터 멜라닌 생성 억제 성분의 분리 = Isolation of Melanin Biosynthesis Inhibitory Compounds from the Rootsof Asarum sieboldii

다국어 초록 (Multilingual Abstract)

compounds were isolated from the roots of Asarum sieboldii and their structures were identified as (±)-car-3-ene-2,5-dione (1), (-)-asarinin (2), (-)-sesamin (3), eucarvone (4), methyleugenol (5), γ-asarone (6), pellitorine (7) and asarinolA (8) by analysis of spectral data. Among them, (-)-asarinin (2) showed the most potent inhibitory efect on melanogenesis,with inhibition rate of 6%.Key word Asarum sieboldi, melanogenesis inhibitor, (-)-asarinin, methyleugenol... .... (Aristolochiaceae). ... .....

참고문헌 (Reference)

1 "theinternational organ for the rapid publication of preliminarycommunications in organic chemistry" nishi : 4137-4140, 1977

2 "metabolitesas markers for pigmented malignant melanoma" 311-, 1983

3 Cabanes, "is a slow-binding inhibitor of catecholaseactivity of tyrosinase" 982-985, 1994

4 "a possible control point in melanin biosynthesis. J. Invest.Dermatol." 192-, 1980

5 "Tyrosinasegene transcription and its control by melanogenicinhibitors. J. Invest. Dermatol." 150-, 1993

6 Hashimoto Kazunori, "Studies on anti-allergic components in the roots of Asiasarum sieboldii" 60 : 124-127, 2004

7 "Stimulation of melanogenesisby cholecalciferol in cultured human melanocytes.Tohoku J. Exp. Med." 451-, 1986

8 Ley, Jakob P, "Stereoselective Enzymatic Synthesis of cis-Pellitorine, a Taste Active Alkamide Naturally Occurring in Tarragon" 2004 : 5135-5140, 2004

9 G, "Recent advances in the chemistry of melanogenesisin mammals" 122-, 1980

10 "Oxyresveratrol as the potent inhibitorvon dopa oxidase activity of mushroom tyrosinase" 243 : 801-803, 1998

11 "Monoterpenes from asiasari radixfrom Asiasarum sp." 3571-3574, 1990

12 Ortonne, J. P.,, "Mechanism that cause abnormal skin color, In Physiology and Pathophysiology" New York, Oxford University Press 489-502, 1998

13 "Mammalian tyrosinase thecritical regulatory control point in melanocyte pigment" 1141-, 1987

14 Park, I. K.,, "Larvicidal activity of isobutylamides identified in Piper nigrum Fruits against three mosquito species" 50 : 1866-1870, 2002

15 Lee, J. Y.,, "Isolation and antifungal activity of kakuol, a propiophenone derivative from Asarum sieboldii rhizome" 61 : 821-825, 2005

16 Matubara, H, "Inhibitory effect of Iichen metabolites and their synthetic analogues on malanin biosynthesis in cultured B-16 mouse melanoma cells" 4 : 3-, 1998

17 "Induction of melanogenesissuppression cellular pharmacology and mode ofdifferential action" 367-, 1988

18 "Immunochemical analysis of themodulation of human melanoma-associated antigens byDNA recombinant immune interferon. Immunol." 288-, 1985

19 "Hormonal control of melanocytes MSHsensitiveadenyl cyclase in the Cloudman melanoma. Yale J.Biol. Med." 583-, 1973

20 Chakrabotry, A. K.,, "Effect of arbutin on melanigenic proteins in human melanocytes" 11 : 206-212, 1998

21 "Comparison of thecharge distributions and barriers to ring inversion of protonatedeucarvone and its boron trihalide adducts. CanadianJournal of Chemistry" 3495-3500, 1977

22 Meepagala, K. M.,, "Antifungal Constituents of the Essential Oil Fraction of Artemisia dracunculus L. Var. dracunculus" 50 : 6989-6992, 2002

23 "A new amide from Asarum forbesii Maxim" 7 : 1-5, 2005

24 Ruchi Acharya, "A mild and convenient procedure for the conversion of toxic β-asarone into rare phenylpropanoids : 2,4,5-trimethoxycinnamaldehyde and γ-asarone" 65 : 764-765, 2002