갑상선 기능에 따른 혈액응고인자의 활성도 변화에 대한 고찰 = Changes in Activities of Coagulation Factors in Thyroid Dysfunction

다국어 초록 (Multilingual Abstract)

Background: Coagulation abnormalities have been reported in patients with thyroid dysfunction. We stud- ied the levels of the coagulation activities in patients with thyroid disorders and the changes of them in response to therapy Methods: Coagulation studies were perfomed in 35 patients with abnormal thyroid function. Nineteen patients had hyperthyroidism and nine patients had hypothyroidism. Seven patients were euthyroid with previous antithyroid therapy. Results: 1) In nineteen patients with hyperthyroidism, the increased activities of factor VIII(170.4±71.3%) showed significant correlations (r=0.73) with increased level of T3 and weak correlations (r=0.50) with the level of T4. All other factors except factor VIII were normal. 2) Seven hyperthyroid patients whose thyroid hormone remained normal with antithyroid therapy showed normal coagulation activities, 3) Nine hypothyroid patients showed decreased activities of several coagulation factors; VIII: 44.2±12. 59%, IX: 56.2±15.0%, XII: 55.0±26.4% 4) Five of them hyperthyroid and two of the hypothyroid patients were followed up. The activities of factor VIII returned to normal after correction of the thyroid function. Conclusion: Hyperthyroidism showed a significant eleevation of factor VIII activity, which returned to normal after antithyroid therapy. Hypothyroidism was associated with subnormal levels of several coagulation factors (factor VIII, IX and XII). It seems unlikely that changes in activities of coagulation factors are caused by a common mechanism in patients with thyroid dysfunction.