Antiviral Activity of 3,4'-Dihydroxyflavone on Influenza A Virus

다국어 초록 (Multilingual Abstract)

Influenza virus infection causes thousands of deaths and millionsof hospitalizations worldwide every year and the emergenceof resistance to anti-influenza drugs has promptedscientists to seek new natural antiviral materials. In this study,we screened 13 different flavonoids from various flavonoidgroups to identify the most potent antiviral flavonoid againsthuman influenza A/PR/8/34 (H1N1). The 3-hydroxyl groupflavonoids, including 3,2'-dihydroxyflavone (3,2'-DHF) and3,4􍿁-dihydroxyflavone (3,4'-DHF), showed potent anti-influenzaactivity. They inhibited viral neuraminidase activityand viral adsorption onto cells. To confirm the anti-influenzaactivity of these flavonoids, we used an in vivo mousemodel. In mice infected with human influenza, oral administrationof 3,4'-DHF significantly decreased virus titers andpathological changes in the lung and reduced body weightloss and death. Our data suggest that 3-hydroxyl group flavonoids,particularly 3,4'-DHF, have potent antiviral activityagainst human influenza A/PR/8/34 (H1N1) in vitro and invivo. Further clinical studies are needed to investigate thetherapeutic and prophylactic potential of the 3-hydroxylgroup flavonoids in treating influenza pandemics.

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