Protein structure

목차 (Table of Contents)

• CONTENTS
• Abbreviations = xi
• Abbreviations for amino acids = xiii
• 1. Basic aspects of polypeptide structure
• The covalent structures of proteins = 1
• Non-covaient forces in protein structure = 3
• Electrostatic interactions = 3
• van der Waals interactions = 5
• Hydrogen bonds = 5
• Hydrophobic interactions = 5
• The amino acid residues = 7
• Primary structures of proteins = 8
• Three-dimensional aspects of polypeptide structure = 9
• Conformations of polypeptides = 9
• Regular polypeptide structures = 13
• The structures of fibrous proteins = 16
• Silk fibroin = 16
• Collagen = 18
• Coiled-coils = 18
• Further reading = 21
• References = 21
• 2. The three-dimensional structures of proteins
• Introduction = 23
• Determining protein structure = 23
• CD spectroscopy = 23
• X-ray diffraction = 24
• NMR spectroscopy = 25
• Structural organization in globular proteins = 26
• Tertiary structure = 26
• Protein interiors and exteriors = 26
• Secondary structure = 27
• Loops and turns = 28
• Disulphide bonds = 28
• Domains = 28
• Supersecondary structure and folding patterns = 30
• Quaternary structure = 35
• Flexibility in protein structures = 37
• Evolutionarily related proteins = 38
• Predicting protein structure = 39
• Protein design = 40
• Further reading = 41
• References = 41
• 3. Proteins in solution and in membranes
• Introduction = 43
• Proteins in aqueous solution = 43
• Aqueous solubility = 43
• Ionization = 44
• Membrane proteins = 45
• Stability of the folded state = 47
• Unfolding = 47
• The thermodynamics of unfolding = 50
• Rationalizing protein stability = 51
• Other factors that affect protein stability = 54
• Protein folding = 55
• General characteristics of protein folding = 55
• Identifying folding intermediates = 56
• Biosynthetic folding = 58
• Further reading = 59
• References = 60
• 4. Ligand binding and protein function
• Introduction = 63
• Ligand binding = 63
• Studying protein―ligand interactions = 63
• General properties of protein―ligand interactions = 64
• The relationship between protein structure and ligand binding = 65
• Calcium-binding proteins = 66
• Redox proteins = 67
• Nucleotide-binding proteins = 69
• DNA-binding proteins = 71
• Helix―turn―helix proteins = 73
• Zinc-containing DNA recognition elements = 73
• Other DNA-binding motifs = 76
• Regulation of ligand binding = 79
• Allosteric regulation = 79
• Reversible covalent modification = 83
• Further reading = 88
• References = 89
• Glossary = 91
• Index = 95