Modifications of T-Scores by Quantitative Ultrasonography for the Diagnosis of Osteoporosis in Koreans

다국어 초록 (Multilingual Abstract)

To identify a proper T-score threshold for the diagnosis of osteoporosis in Koreans
using quantitative ultrasonography (QUS), normative data from 240 females and
238 males (ages 20-29 yr) were newly generated. Then, the osteoporosis prevalence
estimate for men and women over 50 yr of age was analyzed using previous World
Health Organization (WHO) methods and heel QUS. T-scores were calculated from
the normative data. There were definite negative correlations between age and all
of the QUS parameters, such as speed of sound (SOS), broadband ultrasound attenuation
(BUA), and estimated heel bone mineral density (BMD) (p<0.0001). After
applying the recently determined prevalence of incident vertebral fracture in Koreans
over 50 yr of age (11.6% and 9.1%, female vs male, respectively) to the diagnosis
of osteoporosis by T-scores from heel BMD as measured by QUS, it was revealed
that applicable T-scores for women and men were -2.25 and -1.85, respectively.
These data suggest that simply using a T-score of -2.5, the classical WHO
threshold for osteoporosis, underestimates the true prevalence when using peripheral
QUS. Further prospective study of the power of QUS in predicting the absolute
risk of fracture is needed.

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