A New Lignan Glycoside from the Fruits of Cornus kousa Burg

다국어 초록 (Multilingual Abstract)

A new lignan glycoside, (7'S, 8'R)-dihydrodehydrodiconiferyl alcohol-4'-O-β-D-xylopyranoside
(1), named cornuskoside A, was isolated from the fruits of Cornus kousa. The structure of the
compound was determined by spectroscopy, including FABMS, UV, IR, 1H- and 13C-NMR,
DEPT and 2D-NMR (COSY, HSQC, and HMBC). This new lignan glycoside, along with its
aglycone, (7'S, 8'R)-dihydrodehydrodiconiferyl alcohol (3), and another lignan with a similar
skeleton, (-)-balanophonin (2), which have been previously isolated from this plant, were evaluated
for cytotoxicity in human cancer cell lines such as HeLa, MCF-7, SK-MEL-5, and SK-OV-3. Compounds 2 and 3 showed cytotoxicity against HeLa [IC50 = 29.1 μM (2), 45.5 μM (3)], MCF-7 [IC50 = 29.2 μM (2), 28.2 μM (3)], SK-MEL-5 [IC50 = 31.3 μM (2), 32.3 μM (3)], and SKOV-3 [IC50 = 33.4 μM (2), 43.4 μM (3)] cell lines.

참고문헌 (Reference)

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