Central diabetes insipidus results from a lack of sufficient ADH to effect water conservation. The disease is identified by persistence of an inappropriately dilute urine in the presence of strong osmotic or nonosmotic stimuli to ADH secretion, absenc...
Central diabetes insipidus results from a lack of sufficient ADH to effect water conservation. The disease is identified by persistence of an inappropriately dilute urine in the presence of strong osmotic or nonosmotic stimuli to ADH secretion, absence of renal concentrating defects, and a rise in urine osmolality upon administration of vasopressin.
We experienced a case of 29-year old male with persistent polyuria, thirst, and polydipsia due to central diabetes insipidus. The maximal urine osmolality with dehyrdation was 381 mosm/㎏ and urine osmolality was increased by only 26% after vasopressin injection. The serum osmolality at the time of vasopressin injection was 296 mosm/㎏.
So we present this case with a review of literatures.