양극성 조증 입원 환자에서 과체중, 비만과 연관 인자 : 예비 연구 = Factors Associated with Overweight and Obesity in Inpatients with Bipolar Mania : A Preliminary Study

다국어 초록 (Multilingual Abstract)

Objective : Being overweight or obesity impairs quality of life and often causes treatment noncompliance in patients with bipolar disorder. This preliminary study evaluated the prevalence of overweight and obesity in inpatients with bipolar mania. Methods : Inpatients with bipolar mania, who were treated with adequate medications at least 4 weeks were included in a retrospective study. The body weight of each patient was measured and the body mass index (BMI) was calculated. Results : Of the 80 patients, 16.4% (N=13) were overweight, and 35.0% (N=28) were obese at discharge. Female patients had higher prevalence rates of overweight and obesity. Being overweight or obesity was associated with the number of previous episodes of depression and combination treatment with atypical antipsychotics and mood stabilizers. Conclusions : Being overweight or obesity is highly prevalent in patients with bipolar mania. Clinicians should pay more attention to weight gain and obesity when prescribing combination therapies. More research is required to identify the impact of specific risk factors for overweight and obesity in patients with bipolar mania.

참고문헌 (Reference)

1 Fava M, "Weight gain and antidepressants" 61 (61): 37-41, 2000

2 Kim B, "Weight change in the acute treatment of bipolar I disorder: a naturalistic observational study of psychiatric inpatients" 105 : 45-52, 2008

3 Behn A, "The obesity epidemic and its cardiovascular consequences" 21 : 353-360, 2006

4 Allison DB, "The distribution of body mass index among individuals with and without schizophrenia" 60 : 215-220, 1999

5 Stedman T, "The distribution of adipose tissue in female patients receiving psychotropic drugs" 162 : 249-250, 1993

6 Kurzthaler I, "The clinical implications of weight gain in schizophrenia" 62 (62): 32-37, 2001

7 James PT, "The Worldwide Obesity" 9 : 228-233, 2001

8 Shi H, "Sex differences in the regulation of body weight" 97 : 199-204, 2009

9 Nemeroff CB, "Safety of available agents used to treat bipolar disorder: focus on weight gain" 64 : 532-539, 2003

10 Ramacciotti CE, "Relationship between bipolar illness and bingeeating disorders" 135 : 165-170, 2005

11 Vestergaard P, "Prospective studies in a lithium cohort, 3: tremor, weight gain, diarrhea, psychological complaints" 78 : 434-441, 1988

12 Elmslie JL, "Prevalence of over weight and obesity in bipolar patients" 61 : 179-184, 2000

13 Silverstone T, "Prevalence of obesity in patients receiving depot antipsychotics" 153 : 214-217, 1988

14 Kim DM, "Prevalence of obesity in Korea" 6 : 117-121, 2005

15 Fagiolini A, "Prevalence of obesity and weight change during treatment in patients with bipolar I disorder" 63 : 528-534, 2002

16 Tohen M, "Olanzapine versus lithium in the maintenance treatment of bipolar disorder: a 12-month, randomized, double-blind, controlled clinical trial" 162 : 1281-1290, 2005

17 Tohen M, "Olanzapine versus divalproex sodium for the treatment of acute mania and maintenance of remission: a 47-week study" 160 : 1263-1271, 2003

18 Haslam DW, "Obesity" 366 : 1197-1209, 2005

19 Wirshing DA, "Novel antipsychotics: comparison of weight gain liabilities" 60 : 358-363, 1999

20 Grant BF, "Nicotine dependence and psychiatric disorders in the United States: results from the national epidemiologic survey on alcohol and related conditions" 61 : 1107-1115, 2004

21 Rosenbaum M, "Medical progress: obesity" 337 : 396-407, 1997

22 Vornik LA, "Management of comorbid bipolar disorder and substance abuse" 67 (67): 24-30, 2006

23 Marken PA, "Emerging treatments for bipolar disorder: safety and adverse effect profiles" 40 : 276-285, 2006

24 Phillips GB, "Does insulin resistance, visceral adiposity, or a sex hormone alteration underlie the metabolic syndrome?" 57 : 838-844, 2008

25 American Psychiatry Association, "Diagnostic and Statistical Manual of Mental Disorder 4th ed" American Psychiatric Press 1994

26 Elmslie JL, "Determinants of overweight and obesity in patients with bipolar disorder" 62 : 486-491, 2001

27 Kanazawa M, "Criteria and classification of obesity in Japan and Asia-Oceania" 94 : 1-12, 2005

28 McElroy SL, "Correlates of overweight and obesity in 644 patients with bipolar disorder" 63 : 207-213, 2002

29 "Consensus development conference on antipsychotic drugs and obesity and diabetes" 27 : 596-601, 2004

30 Kruger S, "Comorbidity of binge eating disorder and the partial binge eating syndrome with bipolar disorder" 19 : 45-52, 1996

31 Keck PE, "Bipolar disorder, obesity, and pharmacotherapy- associated weight gain" 64 : 1426-1435, 2003

32 Malhotra S, "Associations between metabolic syndrome and psychiatric disorder" 10 : 37-44, 2003

33 Taylor V, "Associations between bipolar disorder and metabolic syndrome: a review" 67 : 1034-1041, 2006

34 Reynolds GP, "Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism" 359 : 2086-2087, 2002

35 Bowden CL, "A randomized, placebo-controlled 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder. Divalproex Maintenance Study Group" 57 : 481-489, 2000