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      KCI등재 SCOPUS

      Blood Count-derived Immunoinflammatory Markers in Thyroidassociated Ophthalmopathy

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      https://www.riss.kr/link?id=A107766467

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      다국어 초록 (Multilingual Abstract)

      Purpose: To investigate the diagnostic and prognostic significance of the blood-count derived systemic immunoinflammatory parameters in patients with thyroid-associated ophthalmopathy (TAO). Methods: In this retrospective case-control study, the blood-count parameters and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio, and systemic immune-inflammatory index (SII), thyroid peroxidase antibody, and anti-thyroglobulin antibody were evaluated in 46 patients with TAO and 46 matched controls. The associations of the immunoinflammatory parameters with clinical outcomes were analyzed among TAO patients. Results: Significant differences were found in NLR, PLR, SII, and lymphocyte count between the controls and the TAO group (p < 0.05 for all). In logistic regression analysis, these inflammatory parameters did not have any prognostic effect on the clinical outcomes of the TAO (p > 0.05 for all). The patients, who needed systemic treatment due to any ocular involvement of TAO during the follow-up period, had significantly lower platelet count (p = 0.001) and PLR (p = 0.02) at the time of initial diagnosis when compared to the no treatment-needed group of the TAO patients. The initial platelet count was significantly associated with the subsequent steroid need due to TAO during the follow-up period (β = -0.02, p = 0.03). Conclusions: NLR, PLR, and SII may serve as potential inflammatory markers in the identification of the TAO, although they have no evident prognostic significance in TAO. However, the relatively lower platelet count at initial diagnosis may be associated with the need for systemic therapy during the follow-up in patients with TAO.
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      Purpose: To investigate the diagnostic and prognostic significance of the blood-count derived systemic immunoinflammatory parameters in patients with thyroid-associated ophthalmopathy (TAO). Methods: In this retrospective case-control study, the blood...

      Purpose: To investigate the diagnostic and prognostic significance of the blood-count derived systemic immunoinflammatory parameters in patients with thyroid-associated ophthalmopathy (TAO). Methods: In this retrospective case-control study, the blood-count parameters and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio, and systemic immune-inflammatory index (SII), thyroid peroxidase antibody, and anti-thyroglobulin antibody were evaluated in 46 patients with TAO and 46 matched controls. The associations of the immunoinflammatory parameters with clinical outcomes were analyzed among TAO patients. Results: Significant differences were found in NLR, PLR, SII, and lymphocyte count between the controls and the TAO group (p < 0.05 for all). In logistic regression analysis, these inflammatory parameters did not have any prognostic effect on the clinical outcomes of the TAO (p > 0.05 for all). The patients, who needed systemic treatment due to any ocular involvement of TAO during the follow-up period, had significantly lower platelet count (p = 0.001) and PLR (p = 0.02) at the time of initial diagnosis when compared to the no treatment-needed group of the TAO patients. The initial platelet count was significantly associated with the subsequent steroid need due to TAO during the follow-up period (β = -0.02, p = 0.03). Conclusions: NLR, PLR, and SII may serve as potential inflammatory markers in the identification of the TAO, although they have no evident prognostic significance in TAO. However, the relatively lower platelet count at initial diagnosis may be associated with the need for systemic therapy during the follow-up in patients with TAO.

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      목차 (Table of Contents)

      • Materials and Methods Results Discussion Conflict of Interest References
      • Materials and Methods Results Discussion Conflict of Interest References
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      참고문헌 (Reference)

      1 Lhotta K, "Treatment of concurrent thrombotic thrombocytopenic purpura and Graves’disease: a report on two cases" 2018 : 5747969-, 2018

      2 Yamada M, "Thyroid-associated ophthalmopathy:clinical features, pathogenesis, and management" 37 : 523-549, 2000

      3 Kurata Y, "Thrombocytopenia in Graves’ disease: effect of T3 on platelet kinetics" 63 : 185-190, 1980

      4 Tabarkiewicz J, "The role of IL-17 and Th17 lymphocytes in autoimmune diseases" 63 : 435-449, 2015

      5 Van der Weerd K, "The peripheral blood compartment in patients with Graves’ disease:activated T lymphocytes and increased transitional and pre-naive mature B lymphocytes" 174 : 256-264, 2013

      6 Tomczynska M, "The mutual cooperation of blood platelets and lymphocytes in the development of autoimmune thyroid diseases" 65 : 17-24, 2018

      7 Armen Yuri Gasparyan, "The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases" 대한진단검사의학회 39 (39): 345-357, 2019

      8 Hu B, "Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma" 20 : 6212-6222, 2014

      9 Jomrich G, "Systemic Immune-Inflammation Index (SII) predicts poor survival in pancreatic cancer patients undergoing resection" 24 : 610-618, 2020

      10 Huang J, "Systemic Immune- Inflammatory Index predicts clinical outcomes for elderly patients with acute myocardial infarction receiving percutaneous coronary intervention" 25 : 9690-9701, 2019

      1 Lhotta K, "Treatment of concurrent thrombotic thrombocytopenic purpura and Graves’disease: a report on two cases" 2018 : 5747969-, 2018

      2 Yamada M, "Thyroid-associated ophthalmopathy:clinical features, pathogenesis, and management" 37 : 523-549, 2000

      3 Kurata Y, "Thrombocytopenia in Graves’ disease: effect of T3 on platelet kinetics" 63 : 185-190, 1980

      4 Tabarkiewicz J, "The role of IL-17 and Th17 lymphocytes in autoimmune diseases" 63 : 435-449, 2015

      5 Van der Weerd K, "The peripheral blood compartment in patients with Graves’ disease:activated T lymphocytes and increased transitional and pre-naive mature B lymphocytes" 174 : 256-264, 2013

      6 Tomczynska M, "The mutual cooperation of blood platelets and lymphocytes in the development of autoimmune thyroid diseases" 65 : 17-24, 2018

      7 Armen Yuri Gasparyan, "The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases" 대한진단검사의학회 39 (39): 345-357, 2019

      8 Hu B, "Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma" 20 : 6212-6222, 2014

      9 Jomrich G, "Systemic Immune-Inflammation Index (SII) predicts poor survival in pancreatic cancer patients undergoing resection" 24 : 610-618, 2020

      10 Huang J, "Systemic Immune- Inflammatory Index predicts clinical outcomes for elderly patients with acute myocardial infarction receiving percutaneous coronary intervention" 25 : 9690-9701, 2019

      11 Fernando R, "Slit2 modulates the inflammatory phenotype of orbit-infiltrating fibrocytes in Graves’ disease" 200 : 3942-3949, 2018

      12 Kristensen B., "Regulatory B and T cell responses in patients with autoimmune thyroid disease and healthy controls" 63 : B5177-, 2016

      13 Abdel Galil SM, "Prognostic significance of platelet count in SLE patients" 28 : 203-207, 2017

      14 Taskaldiran I, "Neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and platelet-tolymphocyte ratio in different etiological causes of thyrotoxicosis" 49 : 1687-1692, 2019

      15 Celik T, "Neutrophil-to-lymphocyte ratio in thyroid ophthalmopathy" 118 : 495-498, 2017

      16 Kurtul BE, "Neutrophil-to-lymphocyte ratio in ocular diseases: a systematic review" 12 : 1951-1958, 2019

      17 Gasparyan AY, "Mean platelet volume in patients with rheumatoid arthritis: the effect of anti-TNF-α therapy" 30 : 1125-1129, 2010

      18 Kuznik BI, "Lymphocyte-platelet crosstalk in Graves’ disease" 347 : 206-210, 2014

      19 Kim SE, "Increased serum interleukin-17 in Graves’ ophthalmopathy" 250 : 1521-1526, 2012

      20 Okamoto A, "Improvement of thrombocytopenia with normalization of thyroid function in a patient with Graves disease" 47 : 536-538, 2006

      21 Klecha AJ, "Immune-endocrine interactions in autoimmune thyroid diseases" 15 : 68-75, 2008

      22 Furuncuoglu Y, "How obesity affects the neutrophil/lymphocyte and platelet/lymphocyte ratio, systemic immune-inflammatory index and platelet indices: a retrospective study" 20 : 1300-1306, 2016

      23 Ma M, "High systemic immune-inflammation index represents an unfavorable prognosis of malignant pleural mesothelioma" 11 : 3973-3979, 2019

      24 Eakin DL, "Effect of therapy on the neutropenia of hyperthyroidism" 76 : 335-337, 1983

      25 Hymes K, "Easy bruising, thrombocytopenia, and elevated platelet immunoglobulin G in Graves’ disease and Hashimoto’s thyroiditis" 94 : 27-30, 1981

      26 Ito S, "Clinical association between thyroid disease and immune thrombocytopenia" 100 : 345-352, 2021

      27 Diacovo TG, "Circulating activated platelets reconstitute lymphocyte homing and immunity in L-selectin-deficient mice" 187 : 197-204, 1998

      28 Tanaka T, "Changes of peripheral mononuclear cell subpopulations in autoimmune thyroid diseases" 61 : 711-723, 1985

      29 Zamora C, "Binding of platelets to lymphocytes: a potential anti-inf lammatory therapy in rheumatoid arthritis" 198 : 3099-3108, 2017

      30 Tang B, "Associations between blood cell profiles and primary open-angle glaucoma: a retrospective case-control study" 63 : 413-422, 2020

      31 Verges B, "Association of Basedow’s disease and autoimmune thrombopenic purpura. No effect of hyperthyroidism on antiplatelet autoimmunity" 10 : 565-569, 1989

      32 Masunaga R, "Alteration of platelet aggregation in patients with thyroid disorders" 46 : 1128-1131, 1997

      33 Lalor P, "Adhesion of flowing leucocytes to immobilized platelets" 89 : 725-732, 1995

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      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2024 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2021-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2020-01-01 평가 등재학술지 선정 (재인증) KCI등재
      2019-12-01 평가 등재후보로 하락 (계속평가) KCI등재후보
      2010-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2009-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2007-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.11 0.11 0.12
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.1 0.13 0.482 0.03
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