각화극세포종과 편평세포암에서 b치-2와 PCNA 면역조직화함염색 비교 = Comparison of Immunohistochemical Staining of bcl-2 and PCNA in Keratoacanthoma and Squamous Cell Carcinoma각화극세포종과 편평세포암에서 b치-2와 PCNA 면역조직화함염색 비교

다국어 초록 (Multilingual Abstract)

Background : The function of the bcl-２ oncogene was known to prolong cell life by inhibiting apoptosis. PCNA have been used as a cellular proliferation marker. Because there are much similarities between Keratoacanthoma(KA) and Squamous Cell Carcinoma(SCC), it is often hard to differentiate KA and SCC, clinically and histopathologically. Although a number of recent studies have been attempted to separate these two entities by immunohistochemical stains, the distinction between KA and SCC may be still debatable and a matter of speculation. Objective : The purpose of this study was to evaluate the usefulness of the method by analyzing immunohistochemical expression of bcl-２ and PCNA in a matter of differentiating KA and SCC. Method : １１ cases of Keratoacanthoma and ２２ cases of Squamous Cell Carcinoma which are conformed by histopathologic examination were stained with bel-２ and PCNA immunohistochemically. Results : １. In KA, The bel-２ was negative in １００% and the PCNA was positive in １００%. ２. In SCC, The bcl-２ was negative in ９５% and the PCNA was positive in １００%. ３. In the pattern of staining of PCNA, KA have more peripheral pattern(７３%) than diffuse pattern(２７%), otherwise SCC have more diffuse pattern(５９%) than peripheral(２７%) and focal pattern(１４%). Conclusion : bcl-２, PCNA, Keratoacanthoma(KA), Squamous Cell Carcinoma(SCC)Our research showed that KA is almost similar to SCC except that there are difference in the pattern of staining of PCNA. According to the result of our study, we think that it is hard to differentiate between KA and SCC only by immunohistochemical staining of PCNA, Although immunohistochemical staining of PCNA would not be a confirmative method, it will help us to distinguish KA from SCC as a supplementary measure. By the fact, more researches are necessary to differentiate KA and SCC by immunohistochemical staining. (Korean J Dermatol ２００２:４０(１２) １４６１∼１４６７)