개의 Giardia 감염에 따른 albendazole, fenbendazole, metronidazole의 치료효과 = The efficacy of albendazole, fenbendazole and metronidazole for treatment of canine Giardia

다국어 초록 (Multilingual Abstract)

Current treatments for canine Giardia infections include albendazole, fenbendazole and metronidazole in the most cases. To compare efficacy of these antimicrobial drugs for treating naturally infected giardiasis in dogs, we used the zinc sulfate concentration technique(ZSCT) to figure out naturally infected with Giardia. In this study, feces were collected from 150 asymptomatic dogs at a kennel, 28 asymptomatic Giardia infected dogs were used by the allocated four group to receive albendazole(group A, 25mg/kg, PO, bid, 7 days), fenbendazole(group F, 50mg/kg, PO, sid, 7 days), metronidazole (group M, 50mg/kg, PO, sid, 7 days), nontreated control(group NC) respectively. Fecal samples from each dog were examined for Giardia cysts within 3 days of the last treatment. Giardia cysts were not detected in the feces of any dog in group F. Cysts were detected in the feces 1 of 7 dogs in group A or in the feces 2 of 7 dogs in group M. In the group NC, cysts were detected in the feces of 7 of 7 dogs. Finally, there was significant difference for efficacy between antimicrobial drugs against Giardia in dogs. Fenbendazole is the most efficacy to have giardiacidal activity.

참고문헌 (Reference)

1 Thompson RCA, "a more effective antigiardial agent in vitro than metronidazole or tinidazole" 375-379, transrsoctropmedhyg1990

2 Marshall MM, "Waterborne protozoan pathogens" 10 : 67-85, 1997

3 Hill SL, "Prevalence of enteric zoonotic organisms in cats" 216 : 687-692, 2000

4 Spain CV, "Prevalence of enteric zoonotic agents in cats less than 1 year old in central New York State" 15 : 33-38, 2001

5 Georgi JR, "Parasitology for veterinarians" 268-269, 1990

6 Lacey E, "Mode of action of benzimidazoles" 1990 6 : 112-115,

7 Caylor KB, "Metronidazole neurotoxicosis in two cats" 37 : 258-262, 2001

8 Dow SW, "Management of anaerobic infections" 1988 18 : 1167-1182,

9 Jergens AE, "Inflammatory bowel disease: current perspec-tives." 29 : 501-521, 1999

10 Taboada J, "Hepatic encephalopathy: clinical signs, pathogenesis, and treatment." 337-355, 1995

11 Wolfe MS, "Giardiasis" 1992 5 : 93-100,

12 Leib MS, "Giardia: diagnosis and treatment." WB Saunders Co. 716-719, 1995

13 Oxberry ME, "Evaluation of the effect of albendazole and metronidazole on the ultrastructure of Giardia duodenalis" 695-703, intjparasitol1994

14 Kirkpatrick CE, "Epizootiology of endoparasitic infections in pet dogs and cats presented to a veterinary teaching hospital" 1988 30 : 113-124,

15 O'Handley RM, "Efficacy of fenbendazole for treatment of giardiasis in calves" 4 : 384-388, 1997

16 Barr SC, "Efficacy of fenbendazole against giardiasis in dogs" 1994 55 : 988-990,

17 Xiao L, "Efficacy of albendazole and fenbendazole against Giardia infection in cattle" 61 : 165-170, 1996

18 Barr SC, "Efficacy of albendazole against giardiasis in dogs" 1993 54 : 926-928,

19 Cedillo Rivera R, "Effects of albendazole on Entamoeba histolytica and Giardia lamblia trophozoites" espi (espi): 63-67,

20 Zimmer JF, "Comparison of four protocols for the treatment of canine giardiasis" 1986 22 : 168-172,

21 Zimmer JF, "Comparison of four protocols for the treatment of canine giardiasis" 1986 22 : 168-172,

22 Dow SW, "Central nervous system toxicosis associated with metronidazole treatment of dogs" 365-368, 1984-1987jamvetmedassoc1989

23 Horton RJ, "Benzimidazoles in a wormy world" 1990 6 : 106-,

24 Papich MG, "Antiulcer therapy" 1993 23 : 497-512,

25 Hall A, "Albendazole as a treatment for infection with Giardia lambia in children Bangladesh" 84-86, transrsoctropmedhyg1993

26 Edlind TD, "Activity of the anthelmintic benzimidazole against Giardia lamblia in vitro" 1990 24 : 1408-1411,

27 Jacobs SR, "A survey of the prevalence of Giardia in dogs presented to Canadian veterinary practices" 42 : 45-46, 2001