The activity-guided fractionation of the extract of the root of Salvia miltiorrhiza B. (Lablatae, Tanshen), led to the isolation of four active components responsible for the anti-allergic activity in vitro. Among them, 15,16-dihydrotanshinone-I and c...
The activity-guided fractionation of the extract of the root of Salvia miltiorrhiza B. (Lablatae, Tanshen), led to the isolation of four active components responsible for the anti-allergic activity in vitro. Among them, 15,16-dihydrotanshinone-I and cryptotanshinone demonstrated significant inhibition of the release of β-hexosaminidase from cultured RBL-2H3 cells in a dose-dependent manner; the IC_(50) values were calculated as 16 and 36 μM, respectively.