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RISS 인기검색어
- 검색키워드
- 주제어 : Cortisone (검색결과 37 건)
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Jing Yu Kangwon National University 2014 국내석사
Glucocorticoids (GCs) are one of major stress hormones that protect the organisms from specific challenges. Voltage-gated potassium channels play a key to end action potentials in excitable cells, to control electrical signaling, and regulate ion flux and calcium transients in non-excitable cells. In the present study, I investigated the effect of cortisone and hydrocortisone on various voltage-gated potassium channels including hERG, human Kv1.5, and human Kv1.3 channels using a Xenopus oocyte expression system and a two-microelectrode voltage clamp amplifier to determine the electrophysiological effect of cortisone and hydrocortisone. Cortisone and hydrocortisone reduced the amplitude of the Kv1.3, Kv1.5, and hERG currents in concentration-dependent manner. Both cortisone and hydrocortisone inhibit the hERG channels in the closed, open, and inactivated state. The inhibitory effect of both cortisone and hydrocortisone on Kv1.3 and Kv1.5 channel current is acute and irreversible. The inhibition degree of cortisone on Kv1.5 decreased progressively from -10 mV to +30 mV, while that of hydrocortisone did not change at the same range of voltage. Cortisone shifted steady-state activation curves of Kv1.3 channel currents to the right direction, while hydrocortisone inhibited Kv1.3 channel steady-state currents more than peak currents and in a pattern of use-dependent block, which suggested an open-block manner. We concluded that Both cortisone and hydrocortisone blocked human Kv1.3, human Kv1.5 and hERG channel expressed in Xenopus oocytes, providing an possible electrophysiological mechanism for effect of cortisone and hydrocortisone on cardiovascular system and immune system. 현대사회의 사람들은 빠른 생활패턴으로 인하여 많은 스트레스를 받고 있다. 지난 90년대의 연구자들은 장기적인 스트레스가 사람의 정신뿐만 아니라 신체에도 악영향을 미치며, 이로 인해 사망에 이를 수 있다고 밝혔다. Hydrocortisone은 Glucocorticoids 의 한 종류로, 중요한 스트레스 호르몬 중에 하나이다. 급작스런 스트레스 상황 시, 신경과 내분비 신호가 시상하부 - 뇌하수체 - 부신 축에 자극을 주게 되면, 부신피질에서 hydrocortisone이 분비된다. 이 호르몬은 심장 근육기능은 촉진시켜 심박 수를 증가시키고, 혈압 및 혈당을 상승시키며, 세기관지 확장, 면역과 소화기능을 억제 시킨다. Voltage-gated K+channel은 K+를 이동시키는 막 단백질이다. 이 channel은 막 전압에 따라 개폐되며, 활동전압에서 안정 막 전압으로 회복시킨다. 또한 전기신호와 Ca2+transients를 조절하여 우리 몸의 수많은 활동을 조절한다. 우리는 cortisone과 hydrocortisone이 xenopus oocyte에 발현시킨 hERG, Kv1.5, Kv1.3 current에 대해, 어떠한 영향을 미치는지 two-microelectrode voltage clamp 시스템을 통하여 측정하였다. 실험 결과, cortisone과 hydrocortisone 모두 농도 의존적으로 hERG, Kv1.5, Kv1.3 전류를 감소시켰다. Cortisone과 hydrocortisone은 hERG channel의 closed와 open상태 모두 channel과 결합하였다. 또한, Kv1.5와 Kv1.3 측정 시 빠른 전류의 감소효과를 보였으며, washing 후에도 원상태로 회복되지 않았다. Cortisone에 의한 Kv1.5 전류의 감소정도는 전압 의존적 이었으며, Kv1.3에서는 steady-state activation curve를 오른 쪽으로 이동 시켰다. Hydrocortisone은 Kv1.3 channel의 open 상태에서 channel과 결합하였다. 결론적으로, 두 약물은 hERG, Kv1.5, Kv1.3 전류를 감소시켰으며, 이러한 결과는 cortisone과 hydrocortisone이 심혈관 및 면역계통에 영향을 미칠 것이라 생각된다.
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Thiamin이 缺乏된 흰쥐에 있어서 Cortisone이 미치는 影響에 關한 硏究
The Study on the Effects of Cortisone to the Thiamine deficient Albino Rats Eijkman first produced polyneuritis in 1897 by feeding chicken with white rice. Since then it has been studied by many workers and thiamine was discovered which is the main factor for protection of polyneuritis by Jansen and Donath in 1926 formular was cleared by Windaus in 1931, and at last Williams Synthesized it in 1935 Physiological action of thiamine is the activation of the enzymes of Pyruvate and α -ketoglutarate decarboxylation and it has been known that thiamine pyrophosphate is active form of thiamine The purpose of this experiment is to compare the tissue respiration with succinic dehydrogenase activities in the livers of thiamine deficient rats with and without administration of cortisone and to investigate the fact as, cortisone on the thiamine deficient rats Rats were grouped in four as follows; I. Control group. II. Cortisone administered control group. III. thiamine deficient group. IV. Cortisone administered, thiamine deficient group. After the rats were fed for 3 weeks, all rats were sacrificed and O₂ consumption and succinic dehydrogenase activities of the livers were determined and the Vitamin C level in blood, adrenal gland and liver was determined and the results were as follows. 1) The growth of the thiamine deficient rats was poor compared with that of the control and the growth of the cortisone administered thiamine deficient rats was liver poorer than that of the thiamine deficient rats which were not administered cortisone but the cortisone administered control rats which were not deficient of thiamine, grew almost well as the control did. 2) The weight of the livers of the thiamine deficient rats reduced compared with that of control. And the administration of cortisone reduced the weight the more 3) The Vitamin C levels in blood and liver of the thiamine deficient rats were lower than those of the control, and cortisone reduced the Vitamin C levels the more 4) There were no differencies between O₂ consumption and succinic dehydrogenase activities of the livers of thiamine deficient rats with and without administration of cortisone and control groups with and without administration of cortisone From this fact, it may be assumed that thiamine deficiency and cortisone did not change much at the glucose oxidation in this experiment.
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鷄胎 長骨成長에 미치는 Cortisone및 Cyclophosphamide의 影響에 關한硏究
This study was to observe the effects of cortisone and cyclophosphmide (endoxan-asta) on growth of the long bones-humerus, ulna, femur, tibiotarsus and tarsomeiatarsus-in the chick embryos, and also studied the relationship between the ratio of the volume of the long bones in control, cortisone & endoxan treated groups and the degree of differention in them by the discriminant function method. The results were summarized as follows: 1. When injected with cortisone acetate, the long bones of the chick embryos were observed with remarkable growth inhibitionin in the first half of embryonal age. 2. The growth inhibition appeared to be much stronger with the group of 5mg dosage than that of 3mg dosage except tarsometatarsus, and 6th day group than 8th day group generally. 3. Endoxan also inhibited the growth of the long bones of the chick embryos in the first half of embryonal age and stronger than with the group of 0.2mg dosage than that of 0.1mg dosage generally. But endoxan of 0.1mg dosage showed no significant evidence of growth inhibition. 4. The discrimination of cortisone treated chick embryos from controlled chick emsbryos was easier than that of endoxan treated embryo from cortisone treated embryos and that of endoxan treated embryos from controlled embryos. 5. In the control and cortisone treated group, individual analysis could be discriminated by the discriminant value.
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Cortisone acetate 投與한 마우스 組織에서의 免疫組織化學的方法에 依한 Toxoplasma 抗原 檢出에 關한 硏究
This study was performed to identify the toxoplasma antigens from the mice tissue chronically infected with Toxoplasma gondii Beverley strain by peroxidase-antiperoxidaae(PAP) method. The 21 mice divided two group, 3 control group and 18 cortisone-treated group. In cortisone-treated group, the mice were injected with 0.5mg of cortisone acetate twice a week for 6 weeks subcutaneously and 3 mice were sacrified at each week. The brain, lung heart, liver, spleen, kidney, small intestine and skeletal muscle of mice were removed immediately after death. The tissues were fixed with 10% buffered neutral formalin, and then PAP method and H-E staining were done. The results were obtained as follows : 1. The cysts were found in the brain entirely, in heart at 4 weeks, and in skeletal muscle at 5 weeks. The number and size of cysts in the brain were increased in proportion to total close of cortisone acetate in mice. Tachyzoites showed at 4.5 anct 6 week in brain. 2. The brain, spleen and skeletal muscle showed highly positive immunoreactivity. The liver, heart and small intestine were moderately positive and, lung and kidney showed weekly positive immunoreactivity by PAP method. 3. There was a chronic inflammatory responses in the brain, liver and heart, but the remaining organs were in almost normal appearance. And tachyzoites were found in the brain, associated with severe inflam matory changes.
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