Effects of Aqueous Extract of Schizandrae Fructus on Lead-Induced Change of Monoamine Neurotransmitters in Hippocampus

Zhao, Rong Jie,Zhao, Zheng Lin,Zhao, Xiu Feng,Zhao, Guang Wen,Li, Meng Quan,Wu, Yi Yan,Li, Jing Qiu,Guan, Li Xin,Kim, Sang-Chan The Korean Medicine Society for the Herbal Formula 2009 대한한의학 방제학회지 Vol.17 No.2

The effects of aqueous extract of Schizandrae Fructus (AESC) on lead (Pb)-induced changes of monoamine neurotransmitters in the hippocampus (HIP) of adult rats were investigated. Male Sprague-Dawley rats were received intraperitoneal (i.p.) administration of Pb acetate (5 mg/kg/d) for 28 days and sacrificed 7 days after the last administration. Concentrations of norepinephrine (NE), dopamine (DA), serotonin (5-HT), 5-hydroxyindole acetic acid (5-HIAA) in HIP were measured by HPLC. There were significant decreases of NE, DA, 5-HT and 5-HIAA in Pb treated rats (P < 0.05), while pretreatment with AESC (100 mg/kg/d or 300 mg/kg/d, p.o., 2 h before Pb) greatly inhibited the decrease of monoamine transmitters, respectively (P < 0.05). Also, AESC (300 mg/kg/d) significantly increased the reduction of glutathione contents and superoxide dismutase activities in HIP induced by chronic Pb. These results suggest that AESC ameliorates Pb-induced depletion of monoamine neurotransmitters in HIP through its antioxidant activity.

Metastasis associated genomic aberrations in stage II rectal cancer

Hong Zhao,Zhi-Zhou Shi,Rui Jiang,Dong-Bing Zhao,Hai-Tao Zhou,Jian-Wei Liang,Xin-Yu Bi,Jian-Jun Zhao,Zhi-Yu Li,Jian-Guo Zhou,Zhen Huang,Ye-Fan Zhang,Jian Wang,Xin Xu,Yan Cai,Ming-Rong Wang,Yu Zhang 한국유전학회 2016 Genes & Genomics Vol.38 No.11

Genomic aberrations of rectal carcinoma, especially DNA copy number changes associated with metastasis were largely unclear. We aim to identify the metastasis associated biomarkers in stage II rectal cancer. Formalin-fixed, paraffin-embedded primary tumor tissues of stage II rectal carcinoma were analyzed by array-based comparative genomic hybridization, and genomic aberrations were identified by Genomic Workbench and SAM software. Copy number changes and mRNA expressions were validated by Real-time PCR in an independent rectal cancer samples. The results showed that the most frequent gains in stage II rectal cancer were at 1q21.2-q23.1, 3p21.31, 11q12.2-q23.3, 12q24.11-q24.31, 12q13.11-q14.1 and losses in 18q11.2-q23, 17q21.33-q22, 13q31.1-q31.3, 21q21.1-q21.3, 8p23.3-p23.1 and 4q22.1-q23. Twenty-two amplifications and five homozygous deletions were also identified. We further found that S100A1 (1q21.3-q23.1), MCM7 (7q22.1) and JUND (19p13.11) were amplified and overexpressed in stage II rectal cancer. Interestingly, the genomic aberrations affected 14 signaling pathways including VEGF signaling pathway and fatty acid metabolism. Most importantly, loss of 13q31.1-q34 and gain of 1q44 were associated with distant metastasis. Our results indicated that these metastasis associated genomic changes may be useful to reveal the pathogenesis of rectal cancer metastasis and identify candidate biomarkers.

ACTIVE LQR MULTI-AXLE-STEERING METHOD FOR IMPROVING MANEUVERABILITY AND STABILITY OF MULTI-TRAILER ARTICULATED HEAVY VEHICLES

You-Qun Zhao,Zhao Wen Deng,Qi Xian Zhao,Bao Hua Wang,Wei Gao,Xin Xin Kong 한국자동차공학회 2022 International journal of automotive technology Vol.23 No.4

Directional performance and highway stability are two important aspects that need to be considered in development and design of a heavy articulated vehicles. To improve the maneuverability and stability of a multi-trailer articulated heavy vehicle (MTAHV), an active linear quadratic regulator (LQR) multi-axle-steering method is designed and examined. First, a linear yaw-plane model with four-degree-of freedom (4-DOF) for MTAHV is built and validated. Thus, a reference model supplying the desired state responses is introduced. Then, an active control algorithm of multi-axle-steering for the rear axles of tractor and full-trailer is investigated, and a LQR controller is proposed based on the linear vehicle model to make the control variables track the desired state responses. The control strategy concentrates on keeping the actual yaw rate and side-slip angle follow the steady-state yaw rate and zero side-slip angle. Finally, the effectiveness of the designed approach on enhancing the maneuverability and stability of the MTAHV have been validated through the simulations of the low-speed 360o roundabout and the single lane-change maneuver with high speed, respectively. The method has a certain reference value for improving the active safety of the MTAHV.

2005년 국제 ITA/EA 컨퍼런스 : 이메일 마케팅 아키텍처 프레임웍: 개념과 패턴

조빙신 ( Bing Xin Zhao ),( Quan Xin Zhang ),( Hai Xin Ding ) 한국ITA학회 2005 학술대회 Vol.2005 No.-

A Video Traffic Flow Detection System Based on Machine Vision

Xin-Xin Wang,Xiao-Ming Zhao,Yu Shen 한국정보처리학회 2019 Journal of information processing systems Vol.15 No.5

This study proposes a novel video traffic flow detection method based on machine vision technology. The threeframedifference method, which is one kind of a motion evaluation method, is used to establish initialbackground image, and then a statistical scoring strategy is chosen to update background image in real time. Finally, the background difference method is used for detecting the moving objects. Meanwhile, a simple buteffective shadow elimination method is introduced to improve the accuracy of the detection for moving objects. Furthermore, the study also proposes a vehicle matching and tracking strategy by combining characteristics,such as vehicle’s location information, color information and fractal dimension information. Experimentalresults show that this detection method could quickly and effectively detect various traffic flow parameters,laying a solid foundation for enhancing the degree of automation for traffic management.

유채 발아실험을 이용한 수용액과 토양 상에서 Pb, Ni과 As의 식물독성 비교

Xin Zhao,이종근,한재마로,김재영 한국폐기물자원순환학회 2013 한국폐기물자원순환학회 학술대회 Vol.2013 No.2

특정 중금속에 대한 식물독성(Phytotoxicity)을 파악하기 위해 오염물질로 처리된 수용액에서의 발아실험(Germination Test)이 일반적으로 수행되고 있는데, 그 결과를 토양오염의 조건에 바로 적용할 수 없다는 한계가 존재한다. 이러한 한계를 극복하고자 토양에서의 발아실험 역시 수행되고 있으나, 이러한 실험들의 경우는 특정 오염수준의 대상 토양을 채취하여 해당 오염 정도에서의 식물독성을 측정하는 일회성의 검증에 그칠뿐더러, 토양 내 중금속 오염수준 변화에 따른 식물독성을 파악할 수도 없다. 또한 토양에서의 발아실험에 소요되는 노력 및 비용이 수용액 실험과 비교해 훨씬 크다는 단점 역시 가지고 있다. 유채는 유료 작물로 어디서나 잘 자라고 그 용도가 다양하여 많은 연구가 이루어진 식물 중 하나이며 중금속으로 오염된 토양의 복원 공법 중 하나인 식물정화기술(Phytoremediation)에서도 흔히 사용되는 식물이다. 또한 수확된 씨앗을 이용하여 바이오디젤(Biodiesel) 생산원료로 이용할 수 있는 장점이 있어 식물정화기술 분야에서 연구가 활발하게 진행되고 있는 식물종이다. 따라서 본 연구의 목적은 서로 다른 상(相, phase)인 수용액과 토양에서 Pb, Ni과 As이 유채에 미치는 영향을 확인하고 그 두 상의 차이 및 상관관계를 조사하여, 대상 식물의 수용액 상 발아실험 결과만을 통해 토양에서의 중금속 농도 및 독성을 추정하기 위한 방법을 제안하고자 하였다.

A review on impacts of soil microplastics on crops

Xin Zhao(조흠),Babar Iqbal,Guanlin Li 대한환경공학회 2022 대한환경공학회 학술발표논문집 Vol.2022 No.11

Secretory Heme Production by Metabolically Engineered Escherichia coli

Xin Rui ZHAO,Kyeong Rok CHOI,Dahyeon PARK,Sang Yup LEE 한국생물공학회 2019 한국생물공학회 학술대회 Vol.2019 No.10

Path Smoothing for Five-Axis Machine Tools Using Dual Quaternion Approximation with Dominant Points

Xin Zhao,Huan Zhao,Xiangfei Li,Han Ding 한국정밀공학회 2017 International Journal of Precision Engineering and Vol.18 No.5

Nowadays, G01 blocks are still the most widely utilized representation form for the tool paths in the five-axis machine tools. Tangency and curvature discontinuities of the linear tool paths may lead to frequent feedrate fluctuation and acceleration variation, which inevitably deteriorate the machining efficiency and quality. To solve this problem, this paper proposed a dual quaternion B-spline approximation method of dominant points to generate smooth tool paths for five-axis CNC machine tools. First, the dominant points, which can characterize the shape of the linear path, are selected for the tool tip location and the tool orientation simultaneously. Such scheme can significantly compress the number of the control points and release the computational load. Then, the linear tool paths are converted to dual quaternions and approximated to dual quaternion B-spline, which can realize the parameter synchronization for the tool tip and tool orientation, and avoid the fitting oscillatory as well. To verify the proposed method, a trajectory generation method for the dual quaternion B-spline is developed. Simulations and experiments on a five-axis machine tool are conducted, and the results demonstrate the feasibility and efficiency of the proposed method.

Design of 1500V solar inverter stack beyond megawatt in NPC1 topology

Xin Hao,Kwok-Wai Ma,Jia Zhao,Xin-Yu Sun 전력전자학회 2017 전력전자학술대회 논문집 Vol.2017 No.7

This paper describes a design concept of NPC1 power stack for 1500VDC megawatt level solar inverter. This stack uses three latest half-bridge IGBT modules with highest power density and operation junction temperature, which enable realization of power level beyond 1MW without paralleling. Critical design concept on loop inductance is explained. Dynamic characteristics are verified by double-pulse test. Thermal characteristics and output power limits are verified by thermal test. Temperature-sensitive component on PCB as output power constraint is identified. Different PCB repositioning solutions are tested to give the overall output power thermal derating curves, which enable output power of 1.15MW at TA=55°C with 15°C thermal margin. The power stack characteristic and performance change under different thermal environment is further analyzed.