Micro-SEARCH의 인터페이스 모듈에 관한 연구

김정두,박미경 대구효성가톨릭대학교 응용과학연구소 1994 응용과학연구논문집 Vol.3 No.-

This paper discusses the interface module for Micro-SEARCH as a component of Intelligent Tutoring System. Micro-SEARCH is a system which manages and operates the learning of subjects concerning nondeterministic tasks in the field of mathematics, such as Trigonometry, Logical Expression, Algebra, Integration, and Differentiation. The study aims to implement the module with the visual display functions on windows through object-oriented programming techniques, providing the users with a graphic-oriented interface. The evaluation of designed interface module showed the convenience and efficiency of the user environment for the management and operation of the system.

다치 논리를 이용한 화상처리의 농도 표현에 관한 연구

정환묵,박미경 대구효성가톨릭대학교 응용과학연구소 1998 응용과학연구논문집 Vol.6 No.2

Since the multiple valued logic is compare with two-valued logic, it is PC high speed processing and increasing information density greatly in logic networks. In this paper, we represent the multiple-valued that gray level necessary image process the benefit of multiple-valued logic.

Panaxadiol and Panaxatriol from Panax ginseng C.A. Meyer Inhibit the Synthesis of Thromboxane $A_2$ in Adrenaline-Stimulated Human Platelet Aggregations

Park, Kyeong-Mee,Rhee, Man-Whee,Park, Hwa-Jin The Korean Society of Ginseng 1994 Journal of Ginseng Research Vol.18 No.1

In adrenaline-stimulated human platelets, panaxadiol (PD) and panaxatriol (PT) from Panax ginseng C.A. Meyer did not inhibit the $Ca^{2+}$-innux, but inhibited the formation of thromboxane $A_2$ and the platelet aggregations. It seems that PD and PT block a pathyway interconvefing arachidonic acids (20:4) to thromboxane $A_2$ (TX $A_2$), because the amount of $Ca^{2+}$ which phospholipase C or phospholipase $A_2$ requires to liberate 20 : 4 from membrane phospholipids was increased by PD and PT. These results mean that PH and PT have an antiplatelet effect by Inhibiting the formation of TX $A_2$.

Aqueous Fraction from Korean Red Ginseng Inhibits the Protein Phosphorylation Induced by Tumor Promoter

Park, Hwa-Jin,Park, Kyeong-Mee,Rhee, Man-Hee,Park, Ki-Hyun The Korean Society of Ginseng 1993 Journal of Ginseng Research Vol.17 No.2

Aqueous fractions from Korean red ginseng inhibited the phosphorylations of 40 KD and 20 KD polypeptides which were induced by phorbol-12-myristate-13-acetate (100 nM) in human platelets. Much more carbohydrates were contained in the aqueous fractions than proteins. An aqueous fraction extracted with methanol, mainly, consists of glycoproteins, molecular weights of which were below 18 KD. We may infer that the aqueous fraction from Korean red ginseng do antitumorous and antiplatelet functions.

Nitric Oxide is Involved in the Immunomodulating Activities of Acidic Polysaccharide from Panax ginseng

Park, Kyeong Mee,Kim, Young Sook,Jeong, Tae Cheon,Joe, Cheol O.,Shin, Han Jae,Lee, You Hui,Nam, Ki Yeul,Park, Jong Dae 영남대학교 약품개발연구소 2001 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-

The effects of an acidic polysaccharide isolated from the ethanol-insoluble and water-soluble fraction of Panax ginseng C.A. Meyer on immunomodulating activities were investigated. A high output nitric oxide synthase (iNOS) was shown in female BALB/c mice administered intraperitoneally with the acidic polysaccharide from ginseng. Newly synthesized iNOS protein was also observed in peritoneal macrophages cultured with interferon-?? and the acidic polysaccharide. Spleen cells from acidic polysaccharide-treated mice did not proliferate in response to concanavalin A. but restored the responsiveness by the cotreatment of N^(c)-monomethy-??-arginine (NMMA) with concanavalin A. The treatment of mice with aminoguanidine, a specific iNOS inhibitor, alleviated the acidic polysaccharide-induced suppression of antibody response to sheep red blood cells. Present results suggest that the immunomodulating activities of the acidic polysaccharide were mediated by the production of nitric oxide.

Effects of Protein Fractions and Ginsenosides from Panax ginseng C.A. Meyer on Substrate Phosphorylation by a Catalytic Fragment of Protein kinase

Park, Hwa-Jin,NO, Young-Hee,Rhee, Man-Hee,Park, Kyeong-Mee,Park, Ki-Hyun 생화학분자생물학회 1994 한국생화학회지 Vol.27 No.4

Histone III is a substrate for in vitro phosphorylation by a catalytic fragment of protein kinase C. Protein kinase C-catalyzed phosphorylation of histone III was induced by 50 nM phorbol-12-myristate-13-acetate (PMA), and inhibited by protein fractions and the ginsenosides-$Rb_1$, $-Rg_1$, and $-Rh_2$ from Panax ginseng CA. Meyer. The protein fraction which was extracted with methanol consisted mainly of glycopeptides with molecular weights below 18 KDa. The protein fraction extracted with acetone consisted of 18 KDa polypeptides. Protein fractions and ginsenosides from Panax ginseng CA. Meyer have antitumor effects since the inhibition of protein kinase C is related to the suppression of tumors.

Non-Saponin Fraction from Panax ginseng C.A. Meyer Inhibits Platelet Aggregation

Park, Kyeong-Mee,Rhee, Man-Hee,Park, Hwa-Jin The Korean Society of Ginseng 1993 Journal of Ginseng Research Vol.17 No.3

Hexane, Hexane/diethylether and chloroform fractions from Panax ginseng C.A. Meyer stroungly inhibitied human platelet aggregation induced by a high dose of thrombin (2$\mu$/ml). Chloroform fraction more strongly inhibited the platelet aggregation than the other two fraction among them. There were fatty acid ester and phosphate ester instead of polyacethylene compounds in the chloroform fraction.

Immunomodulatory Effect of Acidic Polysaccharide Fraction from Korean Red Ginseng (Panax ginseng)

Park, Kyeong Mee,Jeong, Tae Cheon,Kim, Young Sook,Shin, Han Jae,Nam, Ki Yeul,Park, Jong Dae 영남대학교 약품개발연구소 2000 영남대학교 약품개발연구소 연구업적집 Vol.10 No.-

Effects of red ginseng acidic polysaccharides(RGAP) on immune system were studied. The proliferation of spleen cells was induced by RGAP treatment per se. Cotreatment of lipopolysaccharide(100㎍/㎖) or concanavalin A(1㎍/㎖) with RGAP further stimulated the spleen cell proliferation. BALB/c mice treated with RGAP showed a slight splenic hyperplasia and increased antibody forming cell response to sheep red blood cells. Flow cytometry analysis revealed an influx of macrophages in the mice treated with RGAP.

Immunomodulatory Effect of Acidic Polysaccharide Fraction from Korean Red Ginseng (Panax ginseng)

Park, Kyeong-Mee,Jeong, Tae-Cheon,Kim, Young-Sook,Shin, Han-Jae,Nam, Ki-Yeul,Park, Jong-Dae The Korean Society of Pharmacognosy 2000 Natural Product Sciences Vol.6 No.1

Effects of red ginseng acidic polysaccharides (RGAP) on immune system were studied. The proliferation of spleen cells was induced by RGAP treatment per se. Cotreatment of lipopolysaccharide $(100\;{\mu}g/ml)$ or concanavalin A $(1\;{\mu}g/ml)$ with RGAP further stimulated the spleen cell proliferation. BALB/c mice treated with RGAP showed a slight splenic hyperplasia and increased antibody forming cell response to sheep red blood cells. Flow cytometry analysis revealed an influx of macrophages in the mice treated with RGAP.

Inhibitory Effects of Panaxatriol from Panax ginseng C. A. Meyer on Phosphoinositide Breakdown Induced by Thrombin in Platelets

Kyeong-Mee Park,Man-Hee Rhee,Han-Jae Shin,Yong-Bum Song,Hak-Chul Hyun,Ki-Hyun Park,Hyun-Jeong Cho,Sun-A Choi,Hyo-Chan Kang,Kyoung Jin Kim,Hyeong-Soo Kim,Hee-Jin Kang,Woo-Jeong Ok,Dong-Ha Lee,Hwa-Jin P 고려인삼학회 2008 Journal of Ginseng Research Vol.32 No.2

In this study, we have investigated the effect of panaxatriol (PT) on phosphoinositides (PIS) breakdown and Ca<SUP>2+</SUP>-elevation in thrombin-induced platelet aggregation. Thrombin (5U/ml), a potent platelet agonist which activates phospholipase Cβ via protease activated receptor (PAR), hydrolyzed PIS in platelet membrane. The phosphatidylinositol 4, 5-bisphosphate (PIP₂) was hydrolyzed after 10 sec of the thrombin-stimulation, and both the phosphatidylinositol 4-monophosphate (PIP) and phosphatidylinositol (PI) were brokendown after 30 sec of the thrombin-stimulation. However, PT inhibited the thrombin-stimulated hydrolysis of PIP₂, PIP, and PI. On the other hand, thrombin increased the level of phosphatidic acid (PA) which is phosphorylated from diacylglycerol (DG) generated by PIS-hydrolysis. However, PT inhibited the thrombin-increased PA level non-significantly. Thrombin increased cytosolic free Ca<SUP>2+</SUP>[Ca<SUP>2+</SUP>]i) up to 72% as compared with control (30.8±0.9 nM) in intact platelet. However, PT (100 ㎍/ml) inhibited the thrombin-elevated [Ca<SUP>2+</SUP>]i to 100%. These results suggest that PT may have a beneficial effect on platelet aggregation-mediated thrombotic disease by inhibiting thrombin-induced platelet aggregation via suppression of the [Ca<SUP>2+</SUP>]i level and PIS breakdown.