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金德善 대구교육대학교 1966 論文集 Vol.2 No.-
There comes in the orthopedic exercises for the person who is likely to be neglected as physically abnormal and weak to have a harmonized and well-balanced physique. The exercises of this sort are refered to those which are so constituted that they can correct the deformed and make the weakened restore his faculty for games and activities. As the writer believed it to be necessary to consider the compansatory orthopedic exercises which would be effective as suitable and rational measure, against the physical abnormality, he made a study with following steps: 1) to check tke objects of study and the points which need the orthopedic treatment, 2) to identify the nature of orthopedic exercises and apply the principle. 3) to find the practical and effective methods of orthopedic exercises which could be applicable to the whole area of exercises.
國民學校 體育科 敎育課程의 分析硏究 : 合理的인 敎育課程의 改正을 爲하여
金德善 대구교육대학교 1967 論文集 Vol.3 No.-
Since the announcement of new curriculum on February 15, 1963, the revised curriculum has been in practical operation at the elementary school. Through observation and researches based on my own experiences in teaching physical education in classroom, I have found that the current physical education curriculum for the elementary school has many unsatisfactory defects in terms of meeting the needs of contemporary society and realizing educational objectives of the physical education program. From the view points of objectivity and inter-coordination of its subject matters, there is substantial inconsistency in the arrangement and selection of teaching materials compatible with pupil's physical and mental growth. Taking these deficiencies into full consideration, I have attempted in this paper a detailed systematic and comparative analysis based on the physical education curriculum prepared by the Ministry·of education. After a comprehensive investigation of the subject, I have presented a tentative proposal for physical education curriculum in the elementary school with an emphasis on the necessity of revising the current curriculum, hoping that it will be seriously examined and evaluated by specialists in the field.
허규희,허정식,김선욱,이영기,박덕배 제주대학교 생명과학기술혁신센터 2002 제주생명과학연구 Vol.5 No.-
Insulin has a variety of activities like as glucose uptake, inhibition of lipolysis, glycogen biosynthesis in a number of cells and tissues. Recently insulin has known to exert an antiapoptotic activity in different cell systems. However, it is not clear by which insulin can protect apoptosis cells from apoptosis. Thus, CHO cells expressing the human insulin receptors (CHO-IR) were used to evaluate the importances of different signaling steps activated by insulin in this process. The Ras/Raf-1/MEK/ERK cascade and the serine/threonine protein kinase Akt are two survival pathways that may be activated in response to insulin. We tested the hypothesis that inhibition of farnesylated Ras was casually related to manumycin-induced apoptosis and showed that the response to manumycin was found to be independent of K-Ras function. Moreover, blocking Ras/Raf-1/MEK/ERK cascade by the expression of a transdominant inhibitory mSOSI mutant in CHO-IR cells kept cells to sensitive to the antiapoptotic action of insulin. Insulin-dependent activation of Akt was blocked by 4th treatment with manumycin. This study suggest that the deplection of short-lived farnesylated proteins by manumycin suppresses the antiapoptotic action of insulin at least in part by disrupting Aktactivation but not of the K-Ras/Raf-1/MEK/ERK-dependent cascade.
전기 치수 검사 시 역치 자극 이후 과용(過用) 자극 시간의 측정
남기창,안선희,김수찬,김덕원,이승종 大韓齒科保存學會 2004 Restorative Dentistry & Endodontics Vol.29 No.3
Use of electric pulp testing elicits painful response in vital teeth. In this study, we examined the excessive time from pain feeling to stimulation disconnection in clinical situation. D626D (Parkell Inc., USA.) scan type electric pulp tester was used in total of 23 young healthy individuals. Each of the right central incisors and first premolars were used as testing teeth. Stimulation disconnection was achieved by EMG in anterior belly of digastric muscle, finger span, and voice and the excessive stimulation time over the sensory threshold was recorded. As a result, we found that the short responses before the stimulation disconnection appeared following order: EMG, finger span, and voice. The EMG disconnection is suggested to be used to reduce the excessive stimulus time in electric pulp testing.



Acute oral toxicity of the ethyl acetate fraction of <i>Orostachys japonicus</i> in mice
Kim, Seon-Hee,Ryu, Deok-Seon,Lee, Hyeong-Seon,Shin, Hye-Ryoung,Kwon, Ji-Hye,Lee, Dong-Seok Informa Healthcare USA, Inc. 2014 PHARMACEUTICAL BIOLOGY Vol.52 No.10
<P><I>Context</I>: <I>Orostachys japonicus</I> (Crassulaceae) is referred to as Wa-song in Korea. It is used as an anti-inflammatory, antifebrile, hemostatic, and anti cancer agent, and as an antidote.</P><P><I>Objective</I>: The purpose of this study was to evaluate the acute toxicity of the ethyl acetate fraction of <I>O. japonicus</I> (OJE) after the oral administration in Balb/c mice of both sexes.</P><P><I>Materials and methods</I>: Mice were oral administered a single doses of 500, 1000, and 2000 mg/kg of body weight and were monitored for 14 d. Biochemical parameters [aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total protein (TP), globulin (GB), total cholesterol (TC), triglyceride (TG), blood urea nitrogen (BUN), and creatinine (CR)] and histopathological examination of liver were performed.</P><P><I>Results and conclusion</I>: No animals died and no toxic changes were observed in clinical signs, body weight, and organ weight. The LD<SUB>50</SUB> of orally administered OJE was higher than 2000 mg/kg/d in both sexes. No toxicological findings were found in biochemical parameters. In histophathological examination, neutrophilic infiltration was observed at a dose of 2000 mg/kg group in both sexes. These finding suggest that oral administration of OJE does not produce acute toxicity. Therefore, these results could provide satisfactory preclinical evidence of safety to launch clinical trials on standardized formulation of OJE to be a biohealth product.</P>

Kim, Hong-Deok,Lee, Soo-Bin,Ko, Seok-Chun,Jung, Won-Kyo,Kim, Young-Mog,Kim, Seon-Bong The Korean Society of Fisheries and Aquatic Scienc 2018 Fisheries and Aquatic Sciences Vol.21 No.6
Background: Inflammation has been known to associate with many human diseases. The objective of this study was to evaluate an anti-inflammatory effect of ozonated krill (Euphausia superba) oil, which was prepared by the treatment of krill oil using ozone gas. The anti-inflammatory activity was evaluated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Results: Ozonated krill oil significantly inhibited nitric oxide (NO) production and suppressed the mRNA and protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in LPS-stimulated RAW 264.7 macrophages. Ozonated krill oil also reduced the mRNA expression of inflammatory cytokines such as interleukin (IL)-$1{\beta}$, IL-6, and tumor necrosis factor (TNF)-${\alpha}$ in LPS-stimulated RAW 264.7 macrophages. To elucidate the mechanism underlying the anti-inflammatory activity of ozonated krill oil, we evaluated the effects of ozonated krill oil on the activation of mitogen-activated protein kinases (MAPKs) pathway. Ozonated krill oil suppressed the LPS-stimulated phosphorylation of p38 MAPK and c-Jun N-terminal kinases (JNK). Conclusion: This study revealed that the ozonated krill oil exhibited an anti-inflammatory effect in LPS-stimulated RAW 264.7 macrophages. To the best of our knowledge, this is the first report that ozonated krill oil suppressed pro-inflammatory mediator and cytokine expression in LPS-stimulated RAW 264.7 macrophages by inhibiting the phosphorylation of p38 MAPK and JNK.
Sliding Wear Behavior of Steam Generator Tube Materials in Nuclear Power Plants
Kim, Gyung Guk,Kim, Ji Hui,Lee, Kwon Yeong,Kim, Seon Jin,Lee, Deok Hyun,Hur, Do Haeng,Choi, Myung Sik,Han, Jung Ho Trans Tech Publications, Ltd. 2005 Materials science forum Vol.486 No.-
<P>Wear damage of steam generator tubes of nuclear power plants can cause leakage of radioactive substances. So the evaluation of tubes’ integrity is very important from the viewpoint of nuclear ecocide. In the present study, sliding wear behaviors of Inconel 600 and 690 steam generator tube materials mated with 409 stainless steel commonly used as the support plate were investigated at room temperature in an air environment. For more precise prediction of wear behaviors of steam generator tubes, Archard equation was modified, and the modified wear coefficients were estimated as a function of sliding distance. When using the modified Archard equation, the reliabilities for prediction of wear behavior of Inconel 600 and 690 mated with 409 stainless steel increased from 71.8% to 83.8% and from 60.2% to 85.2%, respectively.</P>



