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홍대기(Hong, Dae-Ki),조태경(Cho Tae-kyung),박병수(Park Byoung-soo) 한국산학기술학회 2008 한국산학기술학회논문지 Vol.9 No.5
최근 국내대학 전반에 걸쳐서 공과대학의 우수 지원자가 점차로 감소되고 있는 상황이며 고등학교 수학 교육과정의 부실화에 따른 신입생의 학력저하에 대한 우려 또한 제기되고 있다. 이러한 위기상황에 대응하여 상명대학교에서는 공학교육의 발전 및 혁신을 위해 공학교육 혁신센터를 운영하고 있다. 공학교육 혁신센터는 공학교육 혁신을 위한 장가계획의 일환으로 수학 분야의 교육 강화를 위한 여러 가지 방안을 논의하여 노출하고 있다. 본 논문에서는 상명대학교에서 논의하여 도출한 수학 교육 강화방안을 제시한다. 이러한 결과들은 상명대학교 공과대학과 유사한 환경에 처해있는 다른 학교들의 수학 교육 강화를 위한 참고자료로 활용될 수 있을 것이다. Recently, the number of applicants for the engineering college is gradually decreased all over the nation. Additionally, the concerns of fall of freshman mathematical ability are raised due to the incomplete high school education. Therefore, the local universities endeavor in order to improve the quality of mathematics education, and study the countermeasure against the crisis. As part of these efforts, Sang-Myung University founds the innovation center for engineering education. The center derives several ideas in order to enhance the mathematics education quality. In this paper, the enhancement plans for the mathematics education in Sang-Myung University are proposed. Results in this paper will be helpful for other university to enhance the mathematics education as reference materials.
소화효소가 Helicobacter pylori의 증식과 공포화독소 생성에 미치는 영향
홍대식,강경희,장명웅 고신대학교(의대) 고신대학교 의과대학 학술지 2001 고신대학교 의과대학 학술지 Vol.16 No.1
Background : Global high prevalence rate of Helicobacter pylori infection is well-known fact. However, a large discrepancies exist between the diagnostic data obtained by the PCR and culture method, because the coccoid form of H.pylori which represent the majority form in the biological samples are not viable in the standard BHI broth with 5% horse serum. The component parts of saliva and gastric juice acted as neither stimulator nor inhibitor to the growth of H.pylori remain unclear. Objective : The purpose of this study was to evaluate the influence of amylase, pepsin, mucin, and lysozyme on the growth and vacuolating toxin production and titer of H.pylori in vitro. Materials and Methods : H.pylori 13,39,46,59,72,94,98 and 125 strains were isolated from patients with gastric disease. The digestive enzymes were inoculated in the 5% horse serum-BHI broth following final concentration of amylase (A; 0.20ug/ml), pepsin (P; 0.25ug/ml), mucin (M; 2,5ug/ml), and lysozyme (L; 1.5ug/ml). The vacuolating toxin titers of the culture supernatant were evaluated in the monolayer culture of RK-13 cells. Results : The morphologic conversion from bacillary to horse-shoe to coccoid forms of H.pylori was observed in the BHI broth containing 5% horse serum on day 5 culture. Half of H.pylori was changed from bacillary to coccoidal form on day 7 culture, most population of H.pylori was changed to coccoidal form on day 10 culture, and almost all H.pylori was changed to coccoidal form on day 14 culture. The growth of H.pylori 72, and 94 strains was increased in BHI broth containing each enzyme such as amylase, pepsin, mucin and mixture of two or three enzymes on day 5 and 7 culture. The growth of H.pylori 94 strains was increased in BHI broth containing each enzyme such as amylase, pepsin, mucin, and mixture of two or three enzymes on day 10 and 14 culture. The vacuolating toxin production of H.pylori strains was not influenced by the addition of amylase, pepsin, mucin, and lysozye or mixture of two or three enzymes. The neutralization of vacuolating toxin of H.pylori was not affected by the addition of amylase, pepsin, mucin, and lysozyme or mixture of two or three enzymes. Conclusion : We found that coccoid forms of H.pylori were viable in the standard 5% horse serum BHI media in the presence of amylase, pepsin, mucin, and lysozyme. The present study demonstrates that gastric juice of the stomach supports the viability of H.pylori and that oral route of infection is a plausible hypothesis. This work also demonstrates that gastric environment may not provide a selective advantage for the toxigenic strains of H.pylori.
홍대길,김경훈 한국전시산업융합연구원 2014 한국과학예술융합학회 Vol.18 No.-
The purpose of this study is to explore plans todevelop associated programs between the DaeguNational Science Museum and the local industriesof the Daegu-Gyeongsangbukdo Province. It is tohelp the Museum to perform the basic functions ofscience museums, identify and take on specialtyareas, find a financial source and contribute to thelocal industries. To perform this study, I firstly examined thestatus and geographical nature of the Museum andanalyzed the industrial/science exhibition artefacts. In addition, I found the correlation between sciencemuseums and industries by looking into the casestudies on overseas industrial/science museums andclassified the objectives of science museums. I alsoinvestigated science museums in Korea and theircharacteristics as a science museum. To explore the associated programs betweenthe Museum and the local industries of theDaegu-Gyeongsangbukdo Province, I studied thecurrent status of the region's manufacturingindustry, the industrial development plan by localgovernments and organizations, and local flagshipcompanies. As a result, I identified four ways forthe Museum to work in association with localindustries: collection of artefacts; events; education;and sponsorship. The associated programs of the Museum and theregion's industries presented in this study isexpected to establish a mid- to long-term directionfor development of the Museum.

한국인 여성에서 자궁근종 발생에 관여하는 인자들에 대한 연구 - 후향적 연구 -
홍대기,정민지,김보섭,이정미,조영래,이택후,전상식,Hong, D.G.,Chung, M.J.,Kim, B.S.,Lee, J.M.,Cho, Y.L.,Lee, T.H.,Chun, S.S. 대한생식의학회 2006 Clinical and Experimental Reproductive Medicine Vol.33 No.3
Objective: The purpose of this study is to find out risk factors related to uterine leiomyoma in Korean women and to compare with the results of previous western studies. Methods: A retrospective analysis was carried out. All the cases of uterine leiomyoma (n=244) were diagnosed surgically or sonographically between Jannuary 1998 and December 2004. Total of 269 controls not having uterine leiomyoma were collected from patients who visited Kyungpook national university hospital for routine gynecologic check-up or treatment of their gynecologic or obstetric diseases other than uterine leiomyoma. Data were collected through review of medical records and interviews and analyzed with $x^2$ and logistic regression model. Results: In multivariate analysis, patient's age (OR 1.070; 95% CI 1.041~1.099), number of artificial abortion (OR 1.182; 95% CI 1.018~1.374) and alcohol drinking (OR 1.865; 95% CI 1.231~2.824) had significantly positive correlation with uterine leiomyoma. The duration of lactation was the only factor which had negative correlation (OR 0.985; 95% CI 0.972~0.998). BMI, parity, age at menarche, the duration and interval of menstruation, caffeine consumption and marital status did not show any correlations. Conclusion: In this study, patient's age, number of artificial abortion, and alcohol drinking were the risk factors of uterine leiomyoma in Korean women and the result was similar to that of western studies. Though we couldn't find out the specific risk factors related to the development of uterine leiomyoma in this study, but it has a great meaning to be the first trial in Korean women. The role of information bias should be carefully evaluated and further multicentered, randomized, controlled prospective studies will be needed to know the possible risk factors among Korean women. 목 적: 본 연구의 목적은 한국인 여성에서 자궁근종 발생과 관련된 인자를 찾고 기존 연구 결과와 비교 하는데 있다. 연구방법: 1998년 l월부터 2004년 12월 사이에 경북대학교병원을 정기 검사 및 산부인과 질환을 가진 환자로 치료를 위해 방문한 환자 중 외과적 또는 초음파검사상 자궁근종이 진단된 244명과 자궁근종이 없는 269명을 대조군으로 후향적인 연구를 시행하였다. 자료는 의료기록 조사로 이루어졌으며 통계분석은 $x^2$ 검정과 로지스틱 회귀분석을 시행하였다. 결 과: 다변량분석상 나이, 인공유산 횟수, 음주는 자궁근종 발생과 양의 상관관계를 나타내었으며, 수유기간에 따라서는 그와 반대의 관계를 나타내었다. BMI, 분만력, 초경 나이, 월경기간 및 간격, 카페인 섭취, 결혼 상태는 연관성을 나타내지 않았다. 결 론: 이번 연구는 한국인 여성에서 자궁근종 발생에 관련된 인자에 대한 첫 후향적인 연구로서 의의를 가지지만, 한국인 여성에서의 구체적인 발생인자에 대한 결론을 내리기에는 부족하였다. 따라서 한국인 여성에서의 자궁근종의 발생인자에 대한 향후 장기간에 걸친 대규모의 전향적인 연구가 필요하리라 여겨진다.

공정거래법과 지적재산권법 : 공정거래법 위반의 주장과 지적재산권침해금지소송
홍대식 민사판례연구회 2009 民事判例硏究 Vol.- No.31
지적재산권은 그 행사가 야기하는 법적 상황이 공정거래법상 문제를 제기하는 경우가 적지 않다. 그 이유는 지적재산권의 경우 그 창출을 통한 시장활동을 통하여 시장경제의 활성화를 지향하는 측면이 있다는 사실에서 찾을 수 있다. 이로 인하여 지적재산권의 행사에 공정거래법을 적용하기 위해서는 공통적인 목적이 필요하다. 공정거래법과 지적재산권법은 소비자 후생을 증진하고 기술혁신을 촉진하는 공통적인 목적을 공유하고 있다고 인식되고 있다. 기술혁신과 관련된 목적에 초점을 맞출 때, 기술혁신은 정태적 경쟁과 동태적 경쟁을 포괄하는 경쟁 개념에 기초한 경쟁을 촉진하는 것으로도 이해될 수 있다. 이 논문은 지적재산권 보유자의 일정한 행위가 공정거래법에 위반한다고 판단된 우리나라 하급심 판결을 논의의 소재로 삼고 있다. 판결의 분석을 통해 추출되는 몇 가지 쟁점은 다음과 같다. 지적재산권의 행사와 그 제한에 관한 법적 원리를 어떻게 정립할 것인가, 공정거래법의 목적과 지적재산권법의 목적을 어떻게 이해할 것인가, 그리고 그와 같은 목적들을 실현하기 위한 법적 수단 사이의 긴장을 조정하기 위하여 어떤 법해석적 방법을 사용할 것인가? 이러한 배경 하에, 이 논문은 먼저 지적재산권의 행사와 그 제한에 관한 일반론을 살펴보고(II), 이어서 공정거래법이 지적재산권의 남용을 규제하는 규범으로서 작용하는 상황을 법적 기초와 판단기준이라는 관점에서 고찰한다(III). 이 부분에서는 지적재산권의 행사에 대한 적용제외 원칙을 규정한 공정거래법 제59조과 불공정거래행위를 규정한 공정거래법 제23조가 자세히 검토될 것이다. 그때까지의 논의의 연장선상에서 이 논문은 판단기준의 적합성과 구제수단의 유효성을 평가하는 방식으로 대상 판결을 분석한다(IV). 이상의 논의를 종합하여, 이 논문은 공정거래법과 지적재산권법의 관계는 공통적인 목적을 추구하는 것으로 인식되어야 하고 지적재산권의 허용된 한계를 넘는 행위에 대하여 공정거래법을 적용할 때 그러한 목적에 따른 한계가 설정되어야 한다는 결론을 맺는다. 남은 문제들 부분에서는 향후의 연구과제들이 제시된다(V). Intellectual property right("IPR") raises some competition law issues under the situations caused by the exercise of IPR. The reason can be found in the fact that IPR has an inclination to activate market economy via market activities for the creation of IPR. This requires the common principles to be applied to the exercise of IPR with competition law. Competition law and intellectual property laws are recognized to share the common purpose of promoting innovation and enhancing consumer welfare. Focusing on the purpose relating to innovation, promoting innovation can be also understood as promoting competition based on the competition concept covering both static competition and dynamic competition. This article takes a Korean low court decision which held against IPR owner's certain act as infringing competition law for a discussion source. The analysis of the decision draws several issues; how to establish the legal principles of the enforcement of IPR and its restraints, how to understand the purposes of competition law and intellectual property laws, and which analytic method to use for co-ordinating the tension between legal measures to materialize those purposes. Against this background, this article first deals with the general theories regarding the enforcement of IPR and its restraints(II), and then explores the situations in which competition law works as rules controlling misuse of IPR in light of legal basis and standard(III). In this part, Article 59 of Korean competition law which stipulates exemption principle for the enforcement of IPR and Article 23 of Korean competition law which provides unfair trade practices are closely reviewed. To the extension of the discussion that far, this article analyses the decision in the way to assess the appropriateness of its standard and the effectiveness of its remedies(IV). The discussion leads to the conclusion that the relationship between competition law and intellectual property laws should be perceived as searching for the common purposes and there should set a limitation following such purposes when applying competition law to acts going beyond the permitted limit for the enforcement of IPR. The research subjects later are suggested as a closing(V).