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- 저자 : 한가득 (검색결과 49 건)
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Visible light curable polymer with good biocompatibility for medical application
한가득,김은혜,정진홍,손태일 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
Natural polymers had good biodegradation and antibacterial activity. Photo-curable polymers used to tissue engineering and drug delivery system. We studied the polymer derivatives with visible light reactivity. The structure of the modified polymers was characterized by FT-IR and <sup>1</sup>H NMR. A visible light-induced cross-linking of polymer derivatives was evaluated by micro-patterning. For biocompatibility it was confirmed cell proliferation and cytotoxicity by WST assay. In conclusion, visible light curable polymers would be able to apply more effective in medical field.
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한가득,김은혜,김재원,노승현,손태일 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1
Furfuryl hyaluronic acid derivative (F-HA) was prepared to reduce adhesion of inter-tissue after surgical operation. Hyaluronic acid has biocompatibility, wound-healing effect, and biodegradable properties. In this study, We expect that F-HA could prevent adhesion because F-HA could make physical separation by coating the surgical site. Immobilized ibuprofen as anti-inflammatory drug slowly released and reduced inflammatory response and adhesion. Structure of prepared F-HA was analyzed using <sup>1</sup>H-NMR. Also, for medical application, biocompatibility of F-HA was evaluated by WST assay. From these results, F-HA could be developed as biocompatible anti-adhesion. <sup>**</sup>Acknowledgements : This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and future Planning (No. NRF-2014R1A2A1A11052623)
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Preparation of visible light curable chitosan derivative with hemostatic treatment
한가득,김은혜,정진홍,손태일 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
β-chitosan extracted from squid bone was particularly useful in hemostatic treatment and wound healing because of its stable composition. To increase hemostatic effect, we introduced furfuryl group with visible light reactivity into β-chitosan. Prepared chitosan derivative confirmed to have visible light reactivity by micropatterning. Biocompatability of furfuryl chitosan derivative was evaluated by WST assay. In conclusion, it was demonstrated that photo curable chitosan derivative could be useful for hemostasis and wound healing.
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Development of drug releasing anti-adhesion using visible light cured hyaluronic acid derivative
한가득,김은혜,정진홍,손태일 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0
외과 수술 후에 자주 발생하는 조직 간의 유칙을 방지하기 위해 가시광 반응성 히알루론산 유도체(furfuryl hyaluronic acid, F-HA)를 제조하였다. 뛰어난 생분해성을 지니는 히알루론산에 furfuryl group과 같은 가시광 반응성 작용기를 도입하여 생체 내에서 고정화율을 높였다. 유착방지제로서의 F-HA는 수술 부위의 표면에 광가교로 인해 코팅되어 물리적으로 분리시켜 조직의 유착을 방지할 것으로 기대된다. 더불어 소염제를 함께 광고정화하여 약물방출형 유착방지제로 응용가능하며 수술 후 회복기간 동안 발생 가능한 염증을 감소시킬 수 있을 것으로 사료된다. 제조된 F-HA는 1H-NMR을 이용해 그 구조를 분석하였으며 Micropatterning을 통해 광반응성 및 약물고정화 능력을 확인했다. 의료용 유착방지제로 응용되기 위해 WST assay로 F-HA의 생체적합성을 평가하였다. 이를 통해 F-HA의 약물방출형 유착방지제로의 개발 가능성을 확인하였다.
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Drug-eluting gel using furfuryl chitosan derivatives to prevent post-operation adhesion
한가득,김은혜,김재원,노승현,손태일 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1
Chitosan is a natural polymer that has beneficial properties such as less toxic, biodegradable, and biocompatible than synthetic polymers. Visible light-curable furfuryl chitosan derivatives(F-LMC) had been prepared by introducing furfuryl groups to amino groups of low molecular weight chitosan to prevent post-operation adhesion. The prepared F-LMC was characterized by <sup>1</sup>H NMR and GPC analysis. Photo curing of F-LMC is occurred by a photo-oxidation-induced cross-linking mechanism. The cross-linking was determined by concentration of F-LMC and time of exposure to visible light. The cytotoxicity test using fibroblast 3T3 showed no toxicity of F-LMC. Cross-linked F-LMC surface inhibited cell adhesion. Prepared F-LMC is a novel candidate to prevent post-operation adhesion.
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한가득,김은혜,김재원,노승현,손태일 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1
The purpose of this study is application to drug delivery system for enhancement of osseointegration using UV curable natural polymer derivatives; Azido Gelatin (Az-Gel), Azido Carrageenan (Az-Car), and Azido Low-Molecular-Weight-O-Carboxymethyl Chitosan (Az-LM-O-CMC). Recently, micro-particles using natural polymers were expected to be widely used in the fields of drug delivery system. In drug delivery system, to stabilize the delivery and activity of protein is significant. Bone morphogenetic protein-2 (BMP-2) as an accelerator of osteoblastic differentiation is easy to be deactivated by enzyme and other physical / chemical conditions. In order to solve these problems, photo-immobilization methods have been studied. Azido groups are related to crosslinking reaction as they form a nitrene intermediate by UV irradiation.
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1P-287 Development of poly amino acid hydrogel with vitamin C for bioprosthetics
한가득,손태일,구현철 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
Poly amino acids, which are presented in nature have biocompatibility and biodegradability, and are used in various medical and biological application fields such as cell adhesion, drug delivery, gene therapy and diagnostic. There are three different poly amino acids present in nature, poly-γ-glutamic acid(γ-PGA), poly-ε-lysine (ε-PLS), and cyanophycin. Among them, γ-PGA hydrogel has variety applications in medical device, cosmetics, pharmaceutical and environmental industry for its characteristics of biodegradability, non-toxicity, compatibility and edibility. γ-PGA hydrogel with vitamin C was prepared by using crosslinking reaction by chemical crosslinking agents. The structure of crosslinked γ-PGA hydrogel was analyzed.
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한가득,김은혜,김재원,노승현,손태일 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1
The Purpose of this study was photo-immobilization of BMP-2 using prepared azido-carrageenan derivative (Az-Carr) on collagen sheets and confirmed the effect of bone regeneration by release of the protein. Carrageenan as natural polymer had properties that it was biocompatible, low toxic, anti-viral activity and anti-coagulant for application to medical field. And, carrageenan was used in food and pharmaceutical applications for its gelling and thickening. Prepared Az-Carr identified by <sup>1</sup>H-NMR and uv/vis spectrophotometer. Az-Carr was evaluated drug immobilization and releasing control with BSA protein using protein releasing test. To confirm enhanced bone regeneration, Ca<sup>2+</sup>, ALP assay and Alizarin Red S staining were performed. <sup>**</sup>Acknowledgements : This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and future Planning (No. NRF-2014R1A2A1A11052623)
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