Mouse cell에서 형개연교탕(荊芥連翹湯)의 iNOS 생성 억제 효과

박정훈,김종채,홍승욱,Park, Jung-Hoon,Kim, Jong-Che,Hong, Seung-Ug 대한한방안이비인후피부과학회 2011 한방안이비인후피부과학회지 Vol.24 No.1

Background and Objectives : The aim of this study was to investigate anti-inflammatory and anti-oxidant effects of Hyunggaeyungyo-tang(HYT) on RAW 264.7 cells. Material and Methods : Two types of experiments were implemented for this study: first, the experiment to study the anti-oxidant effect of HYT using riboflavin; second, in vitro experiment to investigate the suppression of NF-${\kappa}$B activation using RAW 264.7 cells (I${\kappa}$B kinase and induce nitric oxide synthase mRNA expression) Results : 1. The anti-oxidant effects of HYT was dose-dependantly increased. 2. The RAW 264.7cells were treated with LPS for 1 hours prior to the addition of indicated concentrations(0.4,-1.0mg/$m\ell$) of HYT, and the cells were further incubated for 24 hours. The LPS-induced IKK & iNOS mRNA expression were dose-dependantly decreased in HYT treated RAW 264.7cells. Conclusion : The results suggest that HYT is significantly effective in the treatment of inflammation through the suppression of NF-${\kappa}$B activation and iNOS production.

알레르기 비염 유발 생쥐에 대한 형개연교탕(荊芥連翹湯)의 iNOS 생성 억제 효과

박정훈,홍승욱,Park, Jung-Hoon,Hong, Seung-Ug 대한한방안이비인후피부과학회 2012 한방안이비인후피부과학회지 Vol.25 No.1

Background and Objectives : Allergic rhinitis is one of the most common diseases in the otorhinolaryngology area. in oriental clinic, Hyunggaeyungyo-tang(HYT) has been used as a primary prescription to treat allergic rhinitis. However, there have been no studies so far performed on the effect of this HYT use. The purpose of this study was find out therapeutic effects of its exclusive use on the rat with allergic rhinitis. Material and Methods : Thirty BALB/c mice were divided into three group : normal group(NOR), control group(CON) inoculated with allergic rhinitis and sample group(SAM) treated with the HYT extract after it was treated the same as the control group. Rats were sensitized intraperitoneally with ovalbumin solution 4times at intervals of 2 days. After that time, rats in SAM were administered by HYT to treat the inflammation. Results : 1. The number of eosinophil in SAM noticeably decreased than CON and this decrease had probability. The inhibition of eosinophil distribution. The infiltration of eosinophil in SAM noticeably decreased than CON. 2. The damaged mucosa as disruption of cilia in respiratory cell, vacant mucose secreting cell and infiltration of inflammation intricate cells in CON were increased than NOR, but SAM same as normal configuration. Decrease of icthing and sneezing intricate neurotransmitter (substance P). Decrease of angiogenesis intricate cytokine(MIP-2). 3. Transcription factor(NF-${\kappa}B$ p65) was decreased. 4. Transcription factor inhibitor(p-$I{\kappa}B$) was decreased. 5. Inflammation cytokine(iNOS) was decreased. Conclusion : The results suggest that HYT is significantly effective in the treatment of inflammation caused by allergic rhinitis through the suppression of NF-${\kappa}B$ activation and iNOS production.

La_0.07Sr_0.3Co_0.2Fe_0.8O_3-δ 분리막의 제조 및 산소투과 특성

박정훈,김종표,백일현,Park, Jung Hoon,Kim, Jong Pyo,Baek, Il Hyun 한국공업화학회 2008 공업화학 Vol.19 No.5

$La_{0.7}Sr_{0.3}Co_{0.2}Fe_{0.8}O_{3-{\delta}$ oxide was synthesized by a citrate method and a typical dense membrane of perovskite oxide has been prepared using as-prepared powder by pressing and sintering at $1300^{\circ}C$. Precursor of $La_{0.7}Sr_{0.3}Co_{0.2}Fe_{0.8}O_{3-{\delta}$ prepared by citrate method was investigated by TGA and XRD. Metal-citrate complex in precursor was decomposed into perovskite oxide in the temperature range of $260{\sim}410^{\circ}C$ but XRD results showed $SrCO_3$ existed as impurity at less than $900^{\circ}C$. Electrical conductivity of membrane increased with increasing temperature but then decreased over $700^{\circ}C$ in air atmosphere ($Po_2=0.2atm$) and $600^{\circ}C$ in He atmosphere ($Po_2=0.01atm$) respectively due to oxygen loss from the crystal lattice. The oxygen permeation flux increased with increasing temperature and maximum oxygen permeation flux of $La_{0.7}Sr_{0.3}Co_{0.2}Fe_{0.8}O_{3-{\delta}$ membrane with 1.6 mm thickness was about $0.31cm^3/cm^2{\cdot}min$ at $950^{\circ}C$. The activation energy for oxygen permeation was 88.4 kJ/mol in the temperature range of $750{\sim}950^{\circ}C$. Perovskite structure of membrane was not changed after permeation test of 40 h and the membrane was stable without secondary phase change with 0.3 mol Sr addition.

위승한격(胃勝寒格)을 시술한 안검경련환자 47례에 대한 임상적 고찰

박정훈,홍승욱,Park, Jung-Hoon,Hong, Seung-Ug 대한한방안이비인후피부과학회 2009 한방안이비인후피부과학회지 Vol.22 No.2

Objectives : This study was performed to observe 47 cases of patients with blepharospasm treated with Wisunghanggyeok(胃勝寒格). Methods : For 28 months from Sep. 2006 to Dec. 2008, we researched 47 blepharospasm patients treated with Wisunghanggyeok(胃勝寒格) who visited the author's clinic. Results & Conclusion: 1. It shows more female patients than male patients, and mostly patients in their fifties. 2. The lesion is shown more on the right side than on the left side, and the left side blepharospasm is cured more effective. 3. The causes of hemifacial spasm are mainly stress and overwork, and there is a 85% improvement of 39 cases from these two causes. 4. The disease period is mainly within 1 week, and that period is the most effective time. 5. The number of treatment is mainly under 5 times, and the effect of treatment over 4 times for week is more available. 6. There are 59.57% of excellent improvement and 23.4% of good improvement, and these make 82.97% improvement of 47cases.

조강형시멘트를 사용한 저온경화형 모르타르의 압축강도 및 유동특성에 미치는 방동제, 내한촉진제 및 감수제의 영향

박정훈,기경국,이한승,김형철,최현국,민태범,Park, Jung-Hoon,Ki, Kyoung-Kuk,Lee, Han-Seung,Kim, Hyeong-Cheol,Choi, Hyun-Kuk,Min, Tae-Beom 한국건축시공학회 2016 한국건축시공학회지 Vol.16 No.5

동절기에 콘크리트를 시공할 경우 초기동해와 강도발현이 지연되는 문제가 있으며, 이를 방지하기 위해서는 콘크리트가 동결하기 이전에 시멘트의 수화반응이 일정수준 이하 진행되는 것이 중요하다. 이에 본 연구는 조강형시멘트를 대상으로 내한성 혼화제를 사용한 저온환경하 콘크리트의 실무활용 가능성을 검토할 목적으로 보온 및 가열양생 없이 저온환경하 모르타르 조건에서 방동제, 감수제 및 내한촉진제의 종류별 사용에 따른 작업성 및 유지성능, 동결온도, 압축강도를 평가하였다. 실험결과 조강형시멘트와 방동제를 사용할 경우 CN 방동제 대비 SN 방동제가 초기 압축강도발현이 증진되었다. 또한, 0분 플로우가 증가하고 20분 플로우가 감소하였는데, FR, RT 감수제를 사용하여 플로우 지속성능이 다소 개선됨을 확인하였다. CF, LS 내한촉진제는 감수제의 종류와 상관없이 전반적으로 강도발현이 증진되었으나, SC 내한촉진제는 RT 감수제에서 강도발현이 미비한 것으로 나타났다.

한국산 장고말속(녹조식물문) 6분류군의 추가

박정훈,이옥민,Park, Jung-Hoon,Lee, Ok-Min 한국조류학회(藻類) 2004 ALGAE Vol.19 No.2

Six taxa of unrecorded Korean species of genus Cosmarium were collected from several freshwater sites of South Korea in 2003. They were 3 species and 3 varieties of Genus Cosmarium. Genus Cosmarium of Korea was reported to totally 273 taxa 125 species, 113 varieties and 35 forms including this study.

폐유리 발포 경량골재를 활용한 보수몰탈 경량화

박정훈,Park, Jung-Hoon 한국건설순환자원학회 2021 한국건설순환자원학회지 Vol.16 No.2

폐유리를 분쇄 및 발포하여 제조한 인공경량골재의 경량모르타르 적용 기초물성 평가

박정훈,Park, Jung-Hoon 한국건설순환자원학회 2019 한국건설순환자원학회지 Vol.14 No.2

저온환경에서 알루미나시멘트를 사용한 모르타르의 단열양생에 따른 기초물성 평가

박정훈,기경국,Park, Jung-Hoon,Ki, Kyoung-Kuk 한국건축시공학회 2017 한국건축시공학회지 Vol.17 No.5

In order to examine the possibility of practical use of aluminate cement concrete at low-temperature environment with insulation method, an experimental studies on flowability, setting time, freezing temperature, size variation and compressive strength of the mortar at low-temperature were conducted. Compressive strength was increased in use of CSA, aluminate cement with gypsum. Workability and physical properties were improved by using aluminate cement and gypsum. In addition, freezing resistance and physical properties were improved by applying the insulation curing method. Especially, when alumina cement and gypsum were used together, the insulation curing method was more effective in improving the compressive strength.

BaTiO₃ 미세 분말의 수열합성 및 특성분석

박정훈,박상도,Park, Jung-Hoon,Park, Sangdo 한국화학공학회 2007 Korean Chemical Engineering Research(HWAHAK KONGHA Vol. No.

미세 $BaTiO_3$ 분말의 합성을 위해 함수 티타니아와 수산화바륨을 원료로 수열합성 실험을 수행하여, 반응시간, 온도, 농도 변화에 따른 전화율, 결정구조 및 생성 분말의 물성을 조사하였다. 전화율에 미치는 영향은 시간 < 온도 < 농도 순이었으며, 2.0 M의 원료를 $180^{\circ}C$에서 2 h 수열합성 시킬 때 최대 전화율을 99.5%를 얻을 수 있었다. 낮은 농도(0.25 M)에서는 고온에서도 미반응 $BaCO_3$와 미반응 $TiO_2$ 생성을 피할 수 없었으며, 이 미반응 물질들은 고온에서 $BaTi_2O_5$를 생성시켜 불순물로 존재하였다. 농도를 높일수록 합성 $BaTiO_3$ 분말의 크기는 작아졌으며, 분말의 Ba/Ti 비도 1에 접근하였다. 2.0M 이상의 농도에서는 $180^{\circ}C$, 2 h 반응에서 Ba/Ti 비는 $1{\pm}0.005$ 이였다. Hydrothermal synthesis was conducted with starting material as Barium hydroxide and hydrous titania ($TiO_2{\cdot}xH_2O$) to obtain barium titanate fine Powder. The conversion, crystal structure and properties of as-prepared powder were investigated according to reaction temperature, time and concentration. The effect of variables on conversion was in order of time < temperature < concentration and the maximum conversion reached to 99.5% in the case of hydrothermal synthesis at $180^{\circ}C$ for 2 h with 2.0 M reactant concentration. At low concentration such as 0.25 M, formation of unreacted $BaCO_3$ and $TiO_2$ was not inevitable at even high reaction temperature and these components converted into $BaTi_2O_5$ at high temperature and remained as impurity. As concentration of reactant increased, the size of as-synthesized $BaTiO_3$ powder deceased and Ba/Ti molar ratio approached into 1, showing Ba/Ti ratio of $1{\pm}0.005$ for reaction at $180^{\circ}C$ for 2 h with 2.0 M concentration.