Total Synthesis of Sulindac and iso-Sulindac via Stereoselective Vinylogous Stork Enamine Claisen-Schmidt Condensation

Kang, Seongeun 부산대학교 2021 국내석사

Metabolism-directed Optimization of N-(1-Phenyl-1H-pyrazol-5-yl)acetamides as Selective Allosteric TrkA Inhibitors

Bang, Seorin 부산대학교 2023 국내석사

Protecting-Group-Free Total Synthesis of Isoampelopsin D via Aryne Multifunctionalization

Kim, Seo Yeong 부산대학교 대학원 2024 국내석사

지하철 승강장 최적 조명제어 설계에 의한 에너지 효과 분석과 제도 개선에 관한 연구

이건우 동국대학교 일반대학원 2024 국내박사

In the rapidly progressing global warming situation, the international co㎜unity, including Korea, is implementing various policies such as improving energy efficiency and supplying new and renewable energy to reduce greenhouse gases. According to the IEA Energy Outlook 2019, energy efficiency improvement is suggested as the most important factor for greenhouse gas reduction. Korea also established a national carbon neutral green growth basic plan in March 2023 to reduce carbon emissions. In recent years, 20% of domestic electricity use is used in the lighting field, so it is important to improve the efficiency of the lighting field. Recently, due to the development of technology, smart LED lighting, which combines lighting control technology and high-efficiency lighting technology, has been designated as a high-efficiency appliance certification item in 2021 to foster the market for the product. In this study, as smart LED lighting is released on the market, a controllable lighting design model for subway platform was suggested. The first step is to determine the lighting facility control pattern through user environment analysis, and secondly, to present the most suitable lighting design for users by determining the appropriate Lamp Lumen Maintenance Hours. The lighting control pattern should be divided into spaces that require lighting and spaces that require lighting selectively, taking into account the time spent in the installation space, moving, movement, congestion, and facility operation time. Through this, the lighting control pattern is determined on a daily, weekly, or monthly basis as needed. In order to evaluate the suitability of the control pattern, lighting design was conducted according to the illuminance calculation method using the maintenance factor of lighting. Among the four elements of the Maintenance Factor, the Lamp Lumen Maintenance Factor (LLMF) is a factor related to the usage time of lighting facilities in lighting design, and LLMF was determined in consideration of the Lamp Lumen Maintenance Hours suitable for the user. Based on this, a lighting design model for each LLMF use was designed through LM-80 and TM-21 analysis, and a maintenance factor calculation model for each lighting design use was presented, and simulation analysis results for each model were derived. Through this study, it was possible to confirm the LLMF calculation method for L70, L80, L90, etc. for each lighting control pattern according to the use purpose that could not be applied in the existing lighting design. In addition, economic and environmental analysis is also possible for lighting facilities with lighting control functions, which can be used to improve the high-efficiency appliance certification In this study, 39 subway station platforms on Line 6 were assumed as target sites, lighting control patterns were presented in consideration of the optimal station operation time and congestion, and the optimal lighting design plan was presented by determining the lamp light speed maintenance time suitable for the platform environment. In the case of smart LEDs reflecting lighting control patterns, LED lamps can be used for 50,000 to 26,000 more hours because they can maintain 80% of the maximum light speed up to 76,000 hours. From an LCC perspective, the study analysed the impacts on initial investment costs, electricity bills, and lighting replacement costs. Three categories were compared: fluorescent lights, LEDs, and smart LEDs. The comparison covered factors such as life, consumption capacity, installation quantity, design cost, installation cost, operating time, replacement cycle, replacement unit price, and monthly power consumption. The analysis period was calculated over 33 years by citing relevant studies. The assumed inflation rate was 3% and an electricity rate increase rate of 4%. According to the LCC analysis, smart LEDs had the highest initial cost, followed by LEDs and fluorescent lights. In terms of electricity rates, fluorescent lights were the highest, followed by LEDs and smart LEDs. It has been confirmed that smart LEDs using lighting control technology have reduced power consumption by more than 60% compared to fluorescent lights and by more than 20% compared to LEDs Fluorescent lights can be introduced at a low cost in the beginning, and LED lighting and smart LED lighting appear to be advantageous for maintenance. The proportion of initial costs, electricity bills, and replacement costs for each light was 1%, 91%, 8%, LED lighting 3%, 89%, 8%, and smart LED lighting 6%, 85%, and 9%. Environmental analysis calculated greenhouse gas emissions by applying greenhouse gas emission coefficients based on electricity use, and fluorescent lamps were the lights with the most greenhouse gas emissions, followed by LEDs and smart LEDs. When smart LEDs are installed, it was analyzed that greenhouse gases can be reduced by 721tCO2 per year compared to fluorescent lamps. In accordance with the government's greenhouse gas reduction policy, the procedure and meaning of reducing greenhouse gases were examined in the public case according to the greenhouse gas target management system, and the procedure and profitability were confirmed when the emission trading system could be sold through external projects. Greenhouse gas reduction can be recognized as Korean Offset Credits(KOC) through verification, which can be converted into a Korean Credit Unit(KCU) and traded in the market. As of July 2022, it is traded at about 14,000 won/KCU. Based on this, the emission trading price can be calculated as 721tCO2 * 14,000won = 10,094,000 won per year . Since the effectiveness of smart lighting reflecting the optimal lighting design was proven in the economic and environmental effect, it was judged that it was necessary to spread as a high-efficiency appliance certification item. Currently, the test system of smart LED certification does not reflect the lighting design based on lighting control, so there is no way to verify economic feasibility, so there is a limit to the distribution. This study presented a test evaluation method for lighting control patterns that can verify test room conditions within actual KOLAS (authorized certification test) based on the railway platform lighting control pattern. The core of the test method consisted of the composition of the lighting control pattern, checking the lighting control function, checking the control operation, measuring the amount of power used, and checking the amount of electricity saved. In conclusion, this study is meaningful in that it is possible to predict the energy saving effects of consumers using smart LEDs by developing a lighting design suitable for the space of use by using the control function, which is a characteristic of smart LEDs, and presenting the test procedure of lighting control patterns and electricity consumption savings, which are important elements of lighting design. In addition, the results of the study can be used to calculate energy savings for individual items through the government's mid- to long-term energy demand management policy and strengthening the standards of the energy labeling scheme.

Synthetic Studies toward Ileabethane-type Ileabethoxazole

Kim, Hui Ae 부산대학교 대학원 2024 국내석사

Collective Total Syntheses of Taiwaniaquinoids

Cong So Tran 부산대학교 대학원 2024 국내박사

Design, Synthesis, and Biological Evaluation of Novel N-(3-Acetamidophenyl)butanamides as Ser273 Phosphorylation Blockers of Peroxisome Proliferator-Activated Receptor γ (PPARγ)

Choi, Bu Chul 부산대학교 대학원 2025 국내석사

Design, Synthesis, and Biological Evaluation of Novel Benzo[b]thiophene 1,1-dioxide Derivatives as Potent STAT3 Inhibitors

Kim, Min Seong 부산대학교 대학원 2024 국내석사

Discovery of Novel N-(4-Oxo-3,4-dihydroquinazolin-2-yl)acetamide Derivatives as Sirt6 Activators Targeting MASH

Tak, Yea Lin 부산대학교 대학원 2025 국내석사

Anticancer effect of LPS and IFN- γ pretreated canine macrophage-derived extracellular vesicles through apoptosis in canine melanoma and osteosarcoma cell lines

이경미 서울대학교 대학원 2020 국내석사

Extracellular vesicles (EVs) are particles naturally released from cells and represent an endogenous mechanism for intercellular communication involving the transport of functionally active biological molecules. In addition to their physiological role, EVs have recently attracted interest as vehicles for delivering therapeutic molecules. The purpose of this study was to evaluate the effect of EV derived from canine M1-polarized macrophages (M1EVs) on canine tumor cells, such as D17 (osteosarcoma cells) and LMeC (melanoma cells), and to determine their effects on immune cells around the tumor. By pretreatment with LPS and IFN-γ, macrophages were polarized to M1 type. In the case of M1EV, the contents of pro-inflammatory cytokines such as TNF-α, IL-6 and IL-1β was increased, and nitrate/nitrite contents were also increased. M1EV induced apoptosis of tumor cells by increasing caspase-3 and caspase-7 activation. In addition, M1EVs decreased expression of CCR4, Foxp3 and CTLA-4 in canine peripheral mononuclear cells cocultured with tumor cells. These results suggest that use of M1EV could be an effective anti-cancer therapeutic approach in melanoma and osteosarcoma and M1EVs can be used as immunomodulators in the tumor microenvironment for cancer treatment. 세포외 소포는 세포로부터 자연적으로 방출된 입자이며 기능적으로 활성화된 생물학적 분자에 대한 수송을 포함한 세포 간 커뮤니케이션을 위한 내인성 메커니즘을 나타낸다. 이러한 생물학적 기능뿐만 아니라, 세포외 소포는 최근 치료 분자를 전달하는 매개체로서 관심을 끌고 있다. 이 연구의 목표는 1형으로 분극된 개 대식세포주 (DH82 cell line)로부터 얻은 세포외 소포(M1EV)의 항암 효과를 개 흑색종 세포주 (LMeC cell line)와 개 골육종 세포주 (D17 cell line)를 통해 평가하고, 주변의 면역 세포에 미치는 영향을 결정하는 것이였다. LPS와 IFN- γ를 전처치하여 DH82 세포를 제1형으로 분극화한 후 세포외 소포를 획득하였다. M1EV 내에 함유된 TNF-α, IL-6 and IL-1β와 같은 전염증성 사이토카인이 증가하였고, nitrate/nitrite 함유량도 또한 증가하였다. 또한 M1EV는 caspase-3와 caspase-7 활성을 증가시킴으로써 종양 세포의 세포자멸사를 유도하였다. 그리고 개 말초 단핵세포와 종양 세포를 공배양하였을 때, M1EV는 개 말초 단핵 세포의 CCR4, Foxp3, 그리고 CTLA-4 발현을 감소시켰다. 이러한 결과는 M1EV가 흑색종 및 골육종에 대한 효과적인 항암 치료 접근법일 수 있고, M1EV가 종양 치료에 있어서 종양 미세환경 내에서의 면역 조절 역할을 할 수 있음을 시사한다.