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- 발행기관 : Asian Pacific Organization for Cancer Prevention (검색결과 16 건)
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Lu, Jing Nan,Panchanathan, Radha,Lee, Won Sup,Kim, Hye Jung,Kim, Dong Hoon,Choi, Yung Hyun,Kim, GonSup,Shin, Sung Chul,Hong, Soon Chan Asian Pacific Organization for Cancer Prevention 2017 Asian Pacific journal of cancer prevention Vol.18 No.11
Objective: Anthocyanins belong to a class of flavonoids, exhibiting antioxidant and anti-inflammatory actions have been reported to have anti-cancer effects. Here, we investigated whether anthocyanins can inhibit cancer cell proliferation, invasion, and angiogenesis in human lung cancer A549 cells, which are critically involved in cancer metastasis. Methods: We used anthocyanins from fruits of Vitis coignetiae Pulliat (AIMs) which has been used in Korean folk medicine for the treatment of inflammatory diseases and cancers. We have performed cell proliferation assays, cell invasion assay, gelatin zymography, wound healing assay and western blotting to examine whether anthocyanins can inhibit cancer cell proliferation, invasion, and angiogenesis in A549 cells. Result: AIMs did not inhibit cancer cell proliferation on A549 cells. Also, AIMs suppressed cancer migration, and invasion by supressing MMP-2 and MMP-9 expression. The Immuno-blotting results also revealed that AIMs suppressed the proteins involved in cancer proliferation (COX-2, C-myc, cyclin D1), migration and invasion (MMP-2, MMP-9), anti-apoptosis (XIAP, and c-IAP2), adhesion and angiogenesis (ICAM-1, VEGF). Conclusion: This study demonstrates that the anthocyanins isolated from fruits of Vitis coignetiae Pulliat inhibit cancer proliferation, cancer migration, and invasion that is involve in cancer-metastasis. This study provides evidence that AIMs might have anti-cancer effects on human lung cancer.
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What Types of Cancer Screening Information are Needed?
Kye, Su Yeon,Cho, Juhee,Noh, Hang-In,Kwak, Min-Son,Chang, Yoon Jung Asian Pacific Organization for Cancer Prevention 2010 Asian Pacific journal of cancer prevention Vol.11 No.3
<P>Objective: Seeking information about cancer is an important means by which individuals acquire cancer-related knowledge and know whether they should be screened for cancer. This study was performed to identify the desired types of cancer screening information and to describe patterns of information-seeking behavior. Methods: In August 2006, a questionnaire was administered to a population of South Korean adults who ranged in age from 40 to 70 years (n = 1,676). The chi-square test, linear regression, and logistic regression were used for data analysis. Results: Only 7.8% of the study population reported seeking information about cancer within the previous 12 months. Respondents were more likely to seek information about cancer if they were younger than 49 years, had a post-high school education, were insured through Medicaid, perceived their health status to be fair or poor/very poor and had received prior cancer screening. The most desired information included methods of cancer screening, followed by procedures, benefits and necessity, and limits and side effects. Factors associated with the need for information were age (i.e., less than 49 years), residence (i.e., non-metropolitan), perceived health status (i.e., fair or poor/very poor), cancer family history, and prior cancer screening. Conclusion: It is important to understand the characteristics of information seekers and non-seekers and to deliver cancer screening information based on individuals' needs to promote higher rates of cancer screening.</P>
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Liver cancer screening in Korea: a report on the 2008 national cancer screening programme.
Lee, Eun-Ha,Han, Mi Ah,Lee, Hoo-Yeon,Jun, Jae Kwan,Choi, Kui Son,Park, Eun-Cheol Asian Pacific Organization for Cancer Prevention 2010 Asian Pacific journal of cancer prevention Vol.11 No.5
<P>Background: The Korean National Cancer Screening Programme (NCSP) for liver cancer was initiated in 2003. The objective of this study was to evaluate participation in the NCSP and provide essential evidence associated with the screening of Korean adults at high risk for liver cancer. Methods: Liver cancer screening was conducted in two stages. During the first, the fraction of the population at high risk for liver cancer was identified through detection of the hepatitis B virus surface antigen (HBsAg) and hepatitis C virus antibodies (anti-HCV Ab). During the second stage, this high-risk population was kept under surveillance to detect liver cancers as quickly as possible, and screening participation rates and recall rates were assessed. We estimated the 95% confidence intervals (CIs) for all outcome measures. Results: In the first stage, 2.57% (95% CI, 2.47-2.67) of Medical Aid Programme (MAP) recipients tested positive for HBsAg and 3.70% (95% CI, 3.25-4.15) tested positive for anti-HCV Ab. The total target population for liver cancer screening in 2008 included 433,822 adults over 40 years of age. Of them, 141,381 (32.6%) participated in the NCSP for liver cancer. Participation rates were 34.9% for National Health Insurance (NHI) recipients and 25.2% for MAP recipients. Among participants, 1,139 individuals exhibited a positive screening result (recall rate = 0.81%). Conclusions: Our findings demonstrate the current status of liver cancer screening in Korea. They provide evidence for implementing an organised liver cancer screening programme among high-risk groups.</P>
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Park, Sohee,Bae, Jisuk,Nam, Byung-Ho,Yoo, Keun-Young Asian Pacific Organization for Cancer Prevention 2008 Asian Pacific journal of cancer prevention Vol.9 No.3
<P>Cancer has become the leading cause of death in many Asian countries. There is an increasing trend in breast, prostate and colon cancers, which are considered as typical of economically developed countries. Although breast and prostate cancer rates are still lower than in western countries, they are particularly rapidly increasing. In this paper, we review recently published literature to identify important etiologic factors affecting the cancer risk in Asian populations. Infectious agents such as Helicobacter pylori, hepatitis B and C viruses, and human papillomavirus were shown to be associated with elevated risks of stomach, liver and cervical cancer, respectively. Tobacco smoking was shown to be significantly associated with higher lung cancer risk and moderately increased all cancer risk. Excessive alcohol drinking appeared to increase the risk of colorectal cancer in Japanese and breast cancer in the Korean population. Betel nut chewing was associated with higher risk of oral and esophageal cancer. In terms of diet, various studies have demonstrated that high caloric and fat intake was associated with breast cancer risk, salted food intake with stomach cancer, aflatoxin B1 with liver cancer, and low fruits and vegetables intake with breast and lung cancer. Environmental exposure to indoor and outdoor air pollution, arsenic, radon, asbestos and second hand smoke was shown to increase the lung cancer risk. Reproductive factors such as late age at first childbirth, early menarche, late menopause, oral contraceptive intake, and short duration of lifetime lactation were shown to be associated with breast and/or colorectal cancer. Cancer has clearly become an emerging health threat in Asia and cancer control programs should be actively implemented and evaluated in this region. Various strategies for cancer control have been developed in some Asian countries, including the set-up of national cancer registries, cancer screening programs, education programs for health behavior change, eradication of Helicobacter pylori and vaccination for hepatitis B and C viruses, and human papilloma virus high risk forms. However, more attention should also be paid to low- and medium-resource Asian countries where cancer incidence rates are high, but neither intensive research on cancer for planning effective cancer control programs, nor easy implementation of such programs are available, due to limited financial resources.</P>
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Midcourse evaluation of the second-term 10-year plan for cancer control in Korea.
Han, Mi Ah,Choi, Kui Son,Park, Jong-Hyock,Moore, Malcolm A,Park, Eun-Cheol Asian Pacific Organization for Cancer Prevention 2011 Asian Pacific journal of cancer prevention Vol.12 No.1
<P>The Korean Ministry of Health and Welfare and the Korean National Cancer Center (NCC) developed the Second-term 10-year Plan for Cancer Control, 2006-2015, on the basis of an evaluation of progress of the First-term Plan for Cancer Control (10-yr PCC) from 2005-2006. The second-term 10-yr PCC started with two main objectives and 35 specific aims in eight focus areas, with the overall goal of reducing the economic burden of cancer. We here assessed the status of the 10-yr PCC objectives by midcourse evaluation in 2010, mid-way through the second term. Based on our evaluation and comments received from the government and the NCC, the Cancer Control 2015 objectives were modified. Of the original two main and 35 specific objectives in eight focus areas, four specific objectives were deleted because they were not relevant to the focus areas and three were revised to reflect changes in data sources or projects. In addition, four new objectives were introduced to reflect new data sources or emerging projects. The 2015 targets of 13 objectives were also modified to reflect the midcourse evaluation. This mid-term exercise provided an opportunity to assess the progress made during the first half of the decade and thereby accurately characterize the current and future status of cancer control and effectively manage cancer-control programs.</P>
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Lee, Hae-Jeung,Lee, Sang-Ah,Choi, Haymie Asian Pacific Organization for Cancer Prevention 2005 Asian Pacific journal of cancer prevention Vol.6 No.1
<P>Chemoprevention is considered a rational strategy for dietary approaches to prevention of cancer. Multiple lines of evidence suggest that many of our dietary principles are able to intervene in the multistage carcinogenesis process and phytic acid (inositol hexaphosphate, IP6), a phytochemical present in a variety of plant species, has been shown to prevent various cancers, including those of the mammary gland, colon and liver. However, the mechanism of chemoprevention by IP6 has not been fully elucidated. In the present study, we examined the effects of inositol and/or IP6 supplementation on rat hepatocarcinogenesis initiated by diethylnitrosamine (DEN) and promoted by partial hepatectomy (PH). Supplementation with either inositol or IP6, or their combination, starting one week prior to administration of DEN, resulted in a significant decrease in both the area and the number of placental glutathione S-transferase positive (GST-P+) foci, a preneoplastic marker for DEN-initiated hepatocarcinogenesis. The administration of inositol and/or IP6 in drinking water caused marked enhancement in the glutathione S-transferase (GST) activity. In addition, the production of thiobarbituric acid reactive substances and the catalase activity were significantly reduced in rats supplemented with inositol and /or IP6. Based on these findings, it is likely that the chemopreventive effects of inositol and/or IP6 on rat hepatocarcinogenesis initiated by DEN and promoted by PH are associated with induction of GST activity and suppression of lipid peroxidation.</P>
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Moore, Malcolm A,Yoo, Keun-Young,Tuncer, Murat Asian Pacific Organization for Cancer Prevention 2009 Asian Pacific journal of cancer prevention Vol.10 No.1
<P>The Asian Pacific Organization for Cancer Prevention was launched approximately 10 years ago with publication of a booklet entitled 'Introduction to Cancer Prevention in Tables and Figures'. This was followed by regular quarterly publication of the APJCP starting in the year 2000 - a new project for a new millenium - and a number of research meetings held across Asia. The journal is now in its 10th year, indexed on PubMed and Science Citation Index (Expanded) and relatively well known (not least for its yellow cover). However, its future after its tenth birthday remains uncertain, as there is no infrastructure in place to ensure continuation after retirement of the present Chief/Managing Editor. The question of what might be the best way forward is the focus for the present 'Editorial Comment'. For financial as well as ecological reasons the APJCP is now an electronic journal, printing and postage for issues of almost 200 pages being beyond the resources available. While the costs are therefore relatively low and primarily limited to staff salaries, they do need to be covered and it cannot be simply assumed that the present support provided by the UICC Japanese National Committee will continue long-term. Therefore comments and suggestions are invited from all interested individuals and institutions as to how the APJCP, and by extension the APOCP, should be organized and financed. All communications received will be given space in the next few issues of the APJCP so that discussion can be fostered and informed decisions made at the 5th APOCP General Assembly Conference in Istanbul, April 2010.</P>
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Moore, Malcolm A.,Sangrajrang, Suleeporn,Bray, Freddie Asian Pacific Organization for Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
In February 6-7th, the Thai National Cancer Institute, the International Agency for Research on Cancer and its Mumbai Hub for Cancer Registration, together with the International Association of Cancer Registries and the APOCP/APJCP, jointly organized an Asian cancer registry forum to discuss regional cooperation for cancer registration. Held in the Grande Mercure Fortune Hotel, Bangkok, the meeting brought together leading scientists in cancer registration from South-East and North-East Asia as well as Australia, India and Iran and IARC itself, with coverage of various priorities and challenges of cancer registries regarding cancer control policy, operational parameters, assessment of survival and contributions to screening, for example. The current situation was highlighted and future directions and possible expansion of activities were discussed, with especial attention to the necessity for networks to help improve cancer registration across Asia and Africa.
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Current status of thyroid cancer screening in Korea: results from a nationwide interview survey.
Han, Mi Ah,Choi, Kui Son,Lee, Hoo-Yeon,Kim, Yeonju,Jun, Jae Kwan,Park, Eun-Cheol Asian Pacific Organization for Cancer Prevention 2011 Asian Pacific journal of cancer prevention Vol.12 No.7
<P>Since 2000, thyroid cancer has been increasing most rapidly in Korea. Although the cause of the increase is not clear, thyroid cancer screening could be identified as one of its causes. The purpose of this study was to examine the screening rate of thyroid cancer and its related factors using nationwide data.</P>
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