족궐음간경(足厥陰肝經) 오수혈 주치(主治)의 특성(特性)과 시동병(是動病)의 연관성(聯關性)에 관한 연구(硏究) -<침구갑을경(鍼灸甲乙經)>을 중심(中心)으로-

성수민,이성수,오세형,황민섭,윤종화,Sung, Su-Min,Lee, Seong-Su,Oh, Se-Hyoung,Hwang, Min-Sub,Yoon, Jong-Hwa 대한침구의학회 2006 대한침구의학회지 Vol.31 No.3

Objectives : It is known that the five Su points are very useful clinically. The following study was undertaken in order to find out the general characteristic and the origin of the five Su points. Methods: We investigated the relation of symptoms that are treated by five Su points and Shi-Dong Suo-Sheng-Bing(是動 所生病). The main reference book was Zhen Jiu Jia Yi jing(鍼灸甲乙經) and the author took Liver Meridian of Foot Gworeum(足厥陰肝經) as an example. Results : 1. Five Su point of Liver Meridian of Foot Gworeum(足厥陰肝經) treats Shi-Dong-Bing(是動病) of Liver Meridian of Foot Gworeum. It is peculiarity of Five Su point of Liver Meridian of Foot Gworeum, differed from the others acupoints. Symptoms of Shi-Dang-Bing appears with the abnormal pulsation of Merdian Gi(脈氣), and the special feature of Shi-Dang-Bing is the symptoms are consisted of disorders of whole body, trobles of an internal organ, and psychosomatic disorders. 2. In <Su Wen San Bu Jiu Hou Lun (素問 三部九候論)>, it is described the part of pulse feeling for Shi-Dong-Bing(是動病) of Liver Meridian of Foot Gworeum(足厥陰肝經) as ‘A region that is 2 Chon(寸) from the basic digital joint of the first toe’. This region is agree with the acupoint of Liver Meridian of Foot Gworeum in <Mai-Jing(脈經)>, <Qian-Jin-Yao-Fang(千金要方)>. And Haeng-gan(行間) Tae-chung(太衝), members of five Su-points of Liver Meridian of Foot Gworeum is situated the same region. So we suppose that the part of pulse feeling for Shi-Dong-Bing of Liver Meridian of Foot Gworeum is transformed into Haeng-gan(行間) Tae-chung(太衝), among the five Su points.

김수영 시에 나타난 우울증의 양상과 치유기제 : 현대성을 기원으로 하는 우울증의 세 차원을 중심으로

김수이(Kim Su-yi) 한국시학회 2010 한국시학연구 Vol.- No.28

Kim Su-young's poem is the first case that figured in earnest the depression which originated from modernity in our poem history. As a text in which the narration and representation of modern depression are recorded, Kim Su-young's poem figures the loss of three dimensions the subject, the object and the other. First, the subject means the one that was deprived of its position by the exchange system of capital and became the object. Kim Su-young expresses the sorrow that the position of the subject is not guaranteed constantly as insider/outsider of an office, a modern social space. Second, the object the endlessly reproduced ghostlike object, that is, products made by the exchange system of modern capital. Kim Su-young, overlooking 'depression' that capital conceal itself through 'liveliness' of products, identifies the discarded and superfluous objects with himself. Third, the modern society intercepts the route enabling cooperation between the subject and the other by ruining lots of 'social ideas'. Kim Su-young finds 'skill of love' that re-discovers the other and the world as the targeted love, sorrowing loss of ideas such as Kim Su-young makes for himself the defense and cure mechanism of depression in the process of reflecting on depressive self. It is the very ‘skill of love’ and ‘glance of an analyst’. If ‘skill of love’ is the skill of 'becoming the subject' that the depressive subject, retreated to one's own inside, re-discovers and re-creates the lost object in the other and the world, 'glance of an analyst' is the skill of 'becoming of the other' continuously renewing oneself, seeing the identity of the depressive self from the viewpoint of a third party. The skill=methodology for coping with the depression created by the depressive subject itself has a significant meaning. This means going forward from passive ethical selection suffering from depression instead of sharing the sin of modern civilization to positive ethical selection curing depression. Kim Su-young, based on modern viewpoint of an analyst reflecting on modernity, pioneered the rare, modern and ethical poetic world in our poetic history.

Solar urticaria in Korean patients

( Sung Min Kim ),( Young Ah Cho ),( Ji Su Lee ),( Ji Youn Hong ),( Jin Hee Kim ),( Joo Ran Hong ),( Hye In Cheon ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Solar urticaria (SU) is an uncommon type of photodermatoses characterized by erythematous wheal with pruritus after sunlight exposure, which shows a female predominance. Only a few studies to analyze the clinical features of SU were reported in Asia. Objectives: We aimed to analyze the clinical and photobiological characteristics of SU in Korea. Methods: We retrospectively investigated the medical records of patients with SU who visited the department of dermatology, Konkuk university medical center from January 2005 to January 2020. Results: Of a total of 44 patients, 36 (81.8%) were male and 8 (18.2%) were female. The mean age at onset was 17.6 years (range, 5-47) and the mean threshold time was 19.7 minutes. Among 32 patients who underwent phototesting, the action spectrum most commonly implicated was ultraviolet (UV) A only in 12 (37.5%), and then visible light (415nm) only was responsible for SU in 8 (25.0%). Three patients (9.4%) were induced by both UVA and visible light (415nm). Even 4 patients (12.5%) were triggered by only natural sunlight. Serum immunoglobulin E levels were measured in 33 patients, and 17 (51.5%) showed values higher than normal. The treatment most widely used were oral antihistamine (43.2%), followed by phototherapy (13.6%). Conclusion: SU is a rare photodermatosis in Korea, which shows a male preponderance. In this study, UVA and visible light (415nm) were predominant action spectrum of SU.

소무蘇武의 충절의식이 한국문화에 끼친 영향

장윤수(Jang, Yun-Su) 동양사회사상학회 2009 사회사상과 문화 Vol.19 No.-

한국과 중국은 가까운 거리에서 오랜 시간 문자를 같이해 왔고, 사상을 같이해 왔다. 그러므로 한국인과 중국인은 그 누구보다도 문화적 상근성相根性을 확보하고 있으며 서로를 잘 이해하고 있다. 비록 최근 한 세기 동안 두 나라에 불어 닥친 엄청난 변화들로 인해 두 나라의 문화가 상당 부분 이질성異質性을 띠기도 했지만, 두 나라 사람들이 갖고 있는 전통문화는 여전히 서로를 잘 이해할 수 있는 통로가 된다. 이 논문의 목적은 소무蘇武의 충절의식이 한국문화에 끼친 영향에 대해 고찰하는 것이다. 소무는 중국이 자랑하는 충절지사忠節之士일 뿐만 아니라 전통사회 한국인들이 존숭하던 삶의 모델이기도 하다. 소무가 보여 준 빛나는 충절과 역경을 이겨내는 인내심은 분명 오늘에 있어서도 상당한 의의를 가지며, 특히 한․중 두 나라 사람들에게는 서로를 좀 더 가깝게 이해할 수 있는 문화적 계제階梯가 될 수 있다. Korea and China use equal character and shared similar thoughts for a long time as the adjoined country. Therefore, Korean and a Chinese are having more cultural similarity, and understand well each other than anyone. There were a lot of changes in the two country during last one century, culture of the two country also changed much so. However, traditional culture of two country people is still important channel that understand each other. As well as Su-Wu is person of loyalty that the China is proud of, it is model of life that tradition society’s korean people respect. The Spirit of Loyalty of Su-Wu and endurance which overcome adversity gives us a lot of impression today. Specially, Su-Wu is bridge which Korea and China two country people make each other intimate.

Lithographically-featured photonic microparticles of colloidal assemblies

Lee, Su Yeon,Kim, Shin-Hyun,Heo, Chul-Joon,Hwang, Hyerim,Yang, Seung-Man Royal Society of Chemistry 2010 Physical chemistry chemical physics Vol.12 No.38

<P>We have described a new and promising strategy for the fabrication of composite and porous photonic crystal microparticles that combines the self-assembly of colloidal particles with photolithography techniques. We fabricated silica/SU-8 composite microparticles with photonic bandgaps <I>via</I> four steps: (1) deposition of the silica colloidal crystals on the photoresist, (2) embedding of the colloidal crystals in the photoresist, (3) UV exposure through a photomask and subsequent development, and (4) release of the microparticles from the substrate. Embedding was performed above the glass transition temperature (<I>T</I><SUB>g</SUB>) of uncrosslinked SU-8. At such temperatures, capillary forces on the silica particles facilitate the migration of colloidal crystals in the SU-8 matrix. Particle migration ceased when the top colloidal crystal layer was trapped at the interface between air and SU-8. In addition, we also prepared porous microparticles with an inverse opaline structure by dissolving the embedded silica particles from the composite structures. The porous microparticles showed enhanced reflectivity at the bandgap position due to the large refractive index contrast. The bandgap position of the microparticles was controlled by the size of the silica particles, which determined the lattice constant. Bilayered composite and porous microparticles with two distinct photonic bandgaps were also prepared by sequential deposition of colloidal crystals composed of two differently sized silica particles.</P> <P>Graphic Abstract</P><P>A new and promising fabrication strategy of photonic crystal microparticles was demonstrated by combining colloidal self-assembly with photolithography. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0cp00134a'> </P>

學生의 學級風土知覺과 學業成就와의 關係硏究

裵秀範 건국대학교 교육대학원 1989 敎育論叢 Vol.12 No.-

The purpose of this study is to clarify the item validity which constitutes MCI questionnaire, and the relation between the classroom climate which students perceive and academic achievement of students. For the purpose, first all a theoretical foundcation was established through relevant literature review and the following of this study was conducted by using questionary survey. According to this result, investigator has four questions as follow: Problem 1. Do the items which is constituted in MCI question-tionaire measure the variables which they purport to measure as intended originally? Problem 2. What kind of correlations do the variables of MCI scale have each other? Problem 3. Will there be high correlation between subscale of classroom climate and academic achievement of each curriculum? Problem 4. Will there be statistically significant difference in correlation between classroom climate of students' perception and academic achievement? To get answers to problems, investigator establishes four hypotheses: Hypothesis Ⅰ. MCI scale will constitute of five subscales. Hypothesis Ⅱ. Subscales of MCI Subscales of MCI will be statistically low correlation. Hypothesis Ⅲ. There will be high correlation between subscale of classroom climate and academic achievement of each curriculum. Hypothesis Ⅳ. There will be statistically significant difference in correlation between classroom climate of students' perception and academic achievement. To test the above hypotheses MCI questionnaire was translatedinto Korean and distributed to random sampling 20 of Su Weon agricultural high school is Su Weon. Thus pilot-studied MCI questionnaire was given out to 1,875 pupils of Dong Pu Chun high school and of Bo Young girls' commercial highschool in the district of northen of Kyeong Ki Do and Su Weon agricultural high school and Su Weon girls' high school and Su Song high school in the district of southern of Kyeong Ki Do. And among them, 1,850 pupils were withdrawn and except for the 78 with insufficient answers excepted, 1,778 were finally accepted as the object of this study. Factor analysis and Pearson's product moment correlation coefficient and ANOVA were applied to verify the above hypotheses. Based on the above results, hypothesis Ⅰ and hypothesis Ⅱ and hypothesis Ⅲ were accepted, but hypothesis Ⅳ was rejected.

Sulfonylurea Herbicide Resistance Mechanism of Some Acetohydroxy Acid Synthase Mutants and New Designed Herbicides Specific to the Mutants

Mun Myong Choe,Hun Chol Kang,In Chul Kim,Hai Su Li,Ming Gen Wu,Im Shik Lee 한국잔디학회 2017 Weed & Turfgrass Science Vol.6 No.1

The mutation rate of proline in the position 197 (Pro197) in acetohydroxy acid synthase (AHAS) is highest among sulfonylurea (SU) herbicide-resistance mutants. Therefore, it is significant to investigate the resistance mechanism for the mutation and to develop the herbicides specific to the mutants. SU herbicide resistance mechanism of the mutants, 197Ser, 197Thr and 197Ala, in AHAS were targeted for designing new SU-herbicide. We did molecular dynamics (MD) simulation for understanding SU herbicide-resistance mechanisms of AHAS mutants and designed new herbicides with docking and MD evaluations. We have found that mutation to 197Ala and 197Ser enlarged the entrance of the active site, while 197Thr contracted. Map of the root mean square derivation (RMSD) and radius gyrations (Rg) revealed the domain indicating the conformations for herbicide resistant. Based on the enlarging-contracting mechanism of active site entrance, we designed new herbicides with substitution at the heterocyclic moiety of a SU herbicide for the complementary binding to the changed active site entrances of mutants, and designed new herbicides. We confirmed that our screened new herbicides bonded to both AHAS wild type and mutants with higher affinity, showing more stable binding conformation than the existing herbicides.

Sulfonylurea Herbicide Resistance Mechanism of Some Acetohydroxy Acid Synthase Mutants and New Designed Herbicides Specific to the Mutants

Choe, Mun Myong,Kang, Hun Chol,Kim, In Chul,Li, Hai Su,Wu, Ming Gen,Lee, Im Shik The Korean Society of Weed ScienceThe Turfgrass So 2017 Weed & Turfgrass Science Vol.6 No.1

The mutation rate of proline in the position 197 (Pro197) in acetohydroxy acid synthase (AHAS) is highest among sulfonylurea (SU) herbicide-resistance mutants. Therefore, it is significant to investigate the resistance mechanism for the mutation and to develop the herbicides specific to the mutants. SU herbicide resistance mechanism of the mutants, 197Ser, 197Thr and 197Ala, in AHAS were targeted for designing new SU-herbicide. We did molecular dynamics (MD) simulation for understanding SU herbicide-resistance mechanisms of AHAS mutants and designed new herbicides with docking and MD evaluations. We have found that mutation to 197Ala and 197Ser enlarged the entrance of the active site, while 197Thr contracted. Map of the root mean square derivation (RMSD) and radius gyrations (Rg) revealed the domain indicating the conformations for herbicide resistant. Based on the enlarging-contracting mechanism of active site entrance, we designed new herbicides with substitution at the heterocyclic moiety of a SU herbicide for the complementary binding to the changed active site entrances of mutants, and designed new herbicides. We confirmed that our screened new herbicides bonded to both AHAS wild type and mutants with higher affinity, showing more stable binding conformation than the existing herbicides.

혈관 생성 억제 제를 투여한 신생마우스 폐 조직에서 Retinoic acid의 세포자멸사의 억제

주선영 ( Sun Young Ju ),조경아 ( Kyoung Ah Cho ),유경하 ( Kyung Ha Ryu ),우소연 ( So Youn Woo ),박은애 ( Eun Ae Park ),조수진 ( Su Jin Cho ) 대한주산의학회 2008 Perinatology Vol.19 No.1

목적: Retinoic acid는 폐포 재생에 중요한 역할을 하는 것으로 알려져 있어서 미숙아의 기관지폐이형성중의 예방에 사용되고 있다. 기관지폐이형성중의 병태생리는 미숙한 폐의 내피세포와 외피세포의 세포자멸사를 일으킴과 관련이 있다. 이에 본 연구에서 VEGFR2 억제가 신생 폐에서 세포자멸사를 증가시키는지, 또 retinoic acid의 투여가 본 폐 발달 억제 동물모형에서 세포자멸사를 억제하는지 알아보고자 하였다. 방법: VEGFR2 억제제인 SU1498을 생후3일된 마우스에 주사하고, 폐포발달이 이루어지는 그 후 10일간 retinoic acid나 위약을 주사하였다. 형태학적인 분석을 하였고, 세표자멸사를 비교분석하기 위해서 TUNEL 염색과 Annexin V을 표지자로 FACS출 시행하였다. 자멸사한 세포를 확인하기 위해서 동일초점 현미경으로 분석하였다. 결과: SU1498를 주사한 마우스에서 폐포면적과 평균폐포용적이 의미 있게 감소하였다. 세포자멸사도 약 3배 의미 있게 증가하였다. 자멸사한 세포는 내피세포와 상피세포에 분포하였다. Retinoic acid를 주사한 약 50%의 세포자멸사가 감소하였고, 형태학적으로 정상에 가까운 폐포 발달이 유지되었다. 결론: VEGFR2 억제를 하면 내피세포와 상피세포의 세포자멸사가 증가되면서 폐 발달이 저해되었다. 이어서 retinoic acid를 주사하면 세포자멸사가 억제되어 폐 발달유지에 도움이 되었다. 이러한 retinoic acid에 의한 세포자멸사의 억제가 기관지폐이형성증 예방에 기여할 것으로 추정된다. Background: Retinoic acid is known to play a role in alveolar regeneration and is used in the prevention of bronchopulmonary dysplasia (BPD) in premature infants. Many factors involved in the pathogenesis of BPD induce apoptosis of the endothelium and epithelium of the premature lung. We hypothesized that VEGFR2 inhibition would increase apoptosis in the newborn lung and retinoic acid would decrease apoptosis in our model of inhibited lung growth. Material and Methods: SU1498, a VEGFR2 inhibitor or vehicle was given to three-day-old mice. Subsequent retinoic acid or vehicle injection was given for ten days for the duration of alveolarization. Morphometric analyses were performed. Apoptosis was assessed with TUNEL staining and Annexin V staining. Co-localization of apoptotic cells with endothelial and epithelial cells was performed. Results: SUI498 injection reduced alveolar surface area and mean alveolar volume in newborn mice. Apoptosis was increased by three-fold in SU1498 injected mice. Apoptotic cells co-localized to endothelial and epithelial cells. Retinoic acid significantly reduced the degree of apoptosis by 50% in SU1498 injected mice and maintained lung development. Conclusion: VEGFR2 inhibition caused an arrest in lung development accompanied by an increase in apoptosis of endothelial and epithelial cells of the neonatal lung in mice. Subsequent retinoic acid treatment reduced apoptosis and we speculate that retinoic acid may preserve lung growth in bronchopulmonary dysplasia by inhibiting apoptosis in the neonatal lung.

일반논문 : 추재 조수삼의 『경원총집(經원總集)』에 대하여

이수진 ( Su Jin Lee ) 한민족문화학회 2007 한민족문화연구 Vol.20 No.-

이 논문은 추재 조수삼이 1793년에 직접 정리한 그의 초기 저작 『경원총집(經원總集)』에 대한 검토이다. 먼저 『경원총집』의 체재와 발간 경위, 그리고 그것이 『추재집(秋齋集)』과 맺고 있는 관계를 살펴보았다. 이를 바탕으로 『경원총집』에 실려 있는 작품세계를 고찰하고 그것이 지닌 자료적 가치 등을 모색하였다. 『경원총집』은 2권으로 이뤄져 있는데 권1에는 『죽서수창(竹西酬唱)』·『다산집유(茶山輯遺)』, 권2에는 『연행기정(燕行紀程)』·『청야만영(靑野漫詠)』이 실려 있다. 먼저 『죽서수창』과 『다산집유』에서는 세속에서 벗어나 자연 속에서의 삶을 영위하고자 하는 은거의식과 함께 신분의 벽을 절감하며 끊임없이 내면의 자아와 세계의 갈등 양상을 엿볼 수 있다. 권2의 『연행기정』편에는 1789년 1차 연행 당시의 견문을 고스란히 담아냈을 뿐만 아니라 그 과정을 순차적으로 기록하고 있어 연행노정을 쉽게 알게 하였다. 이러한 첫 연행은 그의 세계관을 변모시키는 계기가 되었다. 『청야만영』에서는 다양한 교유관계가 드러나는데, 무엇보다도 젊은 시절 실학자 이덕무와의 교유는 추재에게 있어서 현실 사회에 대한 관심을 불러일으키는데 보다 결정적인 역할을 하게 된다. 추재의 문학 연구가 주로 후반기 작품들에 집중되어 있어 전반기 작품들에 대해서는 논의된 바가 거의 없었다. 이러한 점에서 초기 저작 『경원총집』은 추재 문학의 연구 자료로써 상당한 가치를 지닌다. 또한 『경원총집』은 추재가 자신의 저작을 연대순으로 구성한 것이어서 『추재집』의 연대기순 편찬론의 재고는 물론이고 추재 문학 전반에 대한 재검토를 필요로 하게 한다. This study examines 『Gyeongwonchongjip』, one of the early writings by Chujae Jo Su-sam, a middle class literary man in the 18th-19th centuries. This work was authored by Jo himself in 1793. First, I investigated the structure of 『Gyeongwonchongjip』, the procedure of its publication, and its relation with 『Chujaejip』. Based on these, I examine the literary world of the works in 『Gyeongwonchongjip』, and explore their literary values. 『Gyeongwonchongjip』 consists of two volumes <volume 1> contains 『Jukseosuchang』, and 『Dasanjipyu』, and <volume 2> 『Yeonhaenggijeong』, and 『Cheongyamanyeong』. As the date of the writing of 『Yeonhaenggijeong』, which contains the report of the first travel to Khanvalikh in 1789, is clear, it is necessary to reconsider the claim that 『Chujaejip』, which was published in 1939, is edited chronologically. With the 19th century as the middle point, Chujae`s poems in the first half take life in nature as their subject matters, and those in the second half realistic life in the. We can observe a clue to such a change in Chujae`s poems from 『Gyeongwonchongjip』. First, along with the hermitage consciousness that pursues a life in nature beyond the mundane world, we can see aspects of the poet`s incessant conflicts with the inner ego out of his keenly feeling the great wall of social classes from 『Jukseosuchang』, and 『Dasanjipyu』. On the other hand, in <Goryeogungsa> in 『Dasanjipyu』 he expresses his interest in historical conventions. In addition to this, the first travel to Khanvalikh in 1789 would have greatly changed his mind. 『Cheongyamanyeong』 reveals his various friendly relations with others; especially, his association with Lee Deok-mu, a Silhak scholar, is the most prominent. In Chujae`s younger days, his association with Lee would have played a decisive role in making him interested in real society.