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RISS 인기검색어
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- 저자 : Zoheb (검색결과 3 건)
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Topographic effects on tornado-like vortex
Zoheb Nasir,Girma T. Bitsuamlak 한국풍공학회 2018 Wind and Structures, An International Journal (WAS Vol.27 No.2
The effects of steep and shallow hills on a stationary tornado-like vortex with a swirl ratio of 0.4 are simulated and quantified as Fractional Speed Up Ratios (FSUR) at three different locations of the vortex with respect to the crests of the hills. Steady state Reynolds Averaged Naiver Stokes (RANS) equations closed using Reynolds Stress Turbulence model are used to simulate stationary tornadoes. The tornado wind field obtained from the numerical simulations is first validated with previous experimental and numerical studies by comparing radial and tangential velocities, and ground static pressure. A modified fractional speed-up ratio (FSUR) evaluation technique, appropriate to the complexity of the tornadic flow, is then developed. The effects of the hill on the radial, tangential and vertical flow components are assessed. It is observed that the effect of the hill on the radial and vertical component of the flow is more pronounced, compared to the tangential component. Besides, the presence of the hill is also seen to relocate the center of tornadic flow. New FSUR values are produced for shallow and steep hills.
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Molecular Recognition of Methionine-Terminated Peptides by Cucurbit[8]uril
Hirani, Zoheb,Taylor, Hailey F.,Babcock, Emily F.,Bockus, Andrew T.,Varnado, C. Daniel,Bielawski, Christopher W.,Urbach, Adam R. American Chemical Society 2018 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.140 No.38
<P>This Article describes the molecular recognition of peptides containing an N-terminal methionine (Met) by the synthetic receptor cucurbit[8]uril (Q8) in aqueous solution and with submicromolar affinity. Prior work established that Q8 binds with high affinity to peptides containing aromatic amino acids, either by simultaneous binding of two aromatic residues, one from each of two different peptides, or by simultaneous binding of an aromatic residue and its immediate neighbor on the same peptide. The additional binding interface of two neighboring residues suggested the possibility of targeting nonaromatic peptides, which have thus far bound only weakly to synthetic receptors. A peptide library designed to test this hypothesis was synthesized and screened qualitatively for Q8 binding using a fluorescent indicator displacement assay. The large fluorescence response observed for several Met-terminated peptides suggested strong binding, which was confirmed quantitatively by the determination of submicromolar equilibrium dissociation constant values for Q8 binding to MLA, MYA, and MFA using isothermal titration calorimetry (ITC). This discovery of high affinity binding to Met-terminated peptides and, more generally, to nonaromatic peptides prompted a detailed investigation of the determinants of binding in this system using ITC, electrospray ionization mass spectrometry, and <SUP>1</SUP>H NMR spectroscopy for 25 purified peptides. The studies establish the sequence determinants required for high-affinity binding of Met-terminated peptides and demonstrate that cucurbit[<I>n</I>]uril-mediated peptide recognition does not require an aromatic residue for high affinity. These results, combined with the known ability of cucurbit[<I>n</I>]urils to target N-termini and disordered loops in folded proteins, suggest that Q8 could be used to target unmodified, Met-terminated proteins.</P> [FIG OMISSION]</BR>
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Topographic effects on tornado-like vortex
Nasir, Zoheb,Bitsuamlak, Girma T. Techno-Press 2018 Wind and Structures, An International Journal (WAS Vol.27 No.2
The effects of steep and shallow hills on a stationary tornado-like vortex with a swirl ratio of 0.4 are simulated and quantified as Fractional Speed Up Ratios (FSUR) at three different locations of the vortex with respect to the crests of the hills. Steady state Reynolds Averaged Naiver Stokes (RANS) equations closed using Reynolds Stress Turbulence model are used to simulate stationary tornadoes. The tornado wind field obtained from the numerical simulations is first validated with previous experimental and numerical studies by comparing radial and tangential velocities, and ground static pressure. A modified fractional speed-up ratio (FSUR) evaluation technique, appropriate to the complexity of the tornadic flow, is then developed. The effects of the hill on the radial, tangential and vertical flow components are assessed. It is observed that the effect of the hill on the radial and vertical component of the flow is more pronounced, compared to the tangential component. Besides, the presence of the hill is also seen to relocate the center of tornadic flow. New FSUR values are produced for shallow and steep hills.
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