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- 저자 : Zhongliang Sun (검색결과 6 건)
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ZhongLiang Sun,Maiko Satomoto,Koshi Makita 대한마취통증의학회 2015 Korean Journal of Anesthesiology Vol.68 No.4
Background: Sevoflurane exposure during the early postnatal period causes neuroinflammation and neuronal apoptosis in rodents. Bone marrow stromal cells (BMSCs) have been shown to protect and repair the damaged central nervous system, for example in ischemic stroke models. In this study, we investigated whether intravenous administration of BMSCs ameliorated neurodegeneration, induced by sevoflurane exposure, in neonatal rats. Methods: Sprague-Dawley rat pups (postnatal day 7) were exposed to 2% sevoflurane for 6 h (vehicle group, n = 7). BMSCs were administered 30 min after induction of sevoflurane anesthesia (BMSCs group, n = 7). The pups were exposed to carrier gas only, as a negative control (mock anesthesia group, n = 4). We assessed the therapeutic effects of BMSC treatment by measuring expression of the pro-inflammatory cytokine interleukin-6 (IL-6), and levels of cleaved caspase-3, in brain tissues immediately following sevoflurane anesthesia. Results: Analysis of the cleaved caspase-3 bands revealed that levels of activated caspase-3 were elevated in the vehicle group compared with the mock anesthesia group, indicating that a single exposure to sevoflurane at subclinical concentrations can precipitate neuronal apoptosis. BMSC treatment did not suppress apoptosis induced by sevoflurane exposure (compared with the vehicle group). The vehicle group had higher proinflammatory cytokine IL-6 protein levels compared with the mock anesthesia group, indicating that sevoflurane exposure induces IL-6 expression. BMSC treatment suppressed sevoflurane-induced increases in IL-6 expression, indicating that these cells can inhibit the neuroinflammation induced by sevoflurane exposure (vehicle group vs. BMSC group). Conclusions: Intravenous administration of BMSCs reduces neuroinflammation, but does not attenuate apoptosis induced by sevoflurane exposure.
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ZhongLiang Sun,Maiko Satomoto,Yushi U Adachi,Koshi Makita 대한마취통증의학회 2017 Korean Journal of Anesthesiology Vol.70 No.3
Background: Neonatal exposure to anesthetics induces neuronal apoptosis and long-term cognitive dysfunction in rodents. We showed that the nicotinamide adenine dinucleotide phosphate-oxidase inhibitor apocynin not only reduces neurotoxicity by decreasing superoxide levels and preventing mitochondrial dysfunction but also improves long-term memory impairment in neonatal mice exposed to sevoflurane. We also found that after the contextual fear conditioning test, glutamatergic neurons expressed c-Fos (neural activation) regardless of previous exposure to sevoflurane. Moreover, there were fewer c-Fos-expressing glutamatergic neurons in the basolateral amygdala (BLA) after exposure to sevoflurane than after exposure to carrier gas. In this study, we investigated whether the administration of apocynin prior to sevoflurane exposure would preserve glutamatergic neurons in the BLA. Methods: Apocynin (50 mg/kg) was injected intraperitoneally into six-day-old male mice 30 min before 6 h of exposure to 3% sevoflurane or carrier gas only. The mice were allowed to mature and then were subjected to the contextual fear conditioning test. The neural activation and neuron population in the BLA were investigated 2 h later. Results: Administration of apocynin prior to neonatal sevoflurane exposure not only prevented learning deficits but also preserved c-Fos-expressing glutamatergic neurons in the BLA. Conclusions: Apocynin mitigates the cognitive impairment induced by neonatal sevoflurane exposure and preserves c- Fos-expressing glutamatergic neurons in the basolateral amygdala.
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Zhongliang Sun,Yongming Zhang,Xiangyun Deng,Jianbao Li,Chunrong Xiong 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.1
Silicalite-1 and titanium containing silicalite-1 (TS-1) hollow fibers were fabricated with polyethylene imine (PEI) fibers as substrates. The acid treated PEI fibers were positively charged and can be effectively coated with silicalite-1 or TS-1 nanocrystals from their colloidal solution. The adsorbed silicalite-1 or TS-1 nanocrystals grew up and became more compact upon two days of vapor phase Ostwald ripening in autoclave. Silicalite-1 and TS-1 hollow fibers were obtained after calcination at 400 8C in air. The shell thickness of the hollow fibers is 1 mm. Hydroxylation of phenol with H2O2 was investigated over TS-1based catalysts in order to compare influences of nanocrystals composed macrostructure and Al2O3binder on the catalytic activities.
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A Deep Learning-Based Image Semantic Segmentation Algorithm
Chaoqun Shen,Zhongliang Sun 한국정보처리학회 2023 Journal of information processing systems Vol.19 No.1
This paper is an attempt to design segmentation method based on fully convolutional networks (FCN) andattention mechanism. The first five layers of the Visual Geometry Group (VGG) 16 network serve as the codingpart in the semantic segmentation network structure with the convolutional layer used to replace pooling toreduce loss of image feature extraction information. The up-sampling and deconvolution unit of the FCN isthen used as the decoding part in the semantic segmentation network. In the deconvolution process, the skipstructure is used to fuse different levels of information and the attention mechanism is incorporated to reduceaccuracy loss. Finally, the segmentation results are obtained through pixel layer classification. The results showthat our method outperforms the comparison methods in mean pixel accuracy (MPA) and mean intersectionover union (MIOU).
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A Novel Low-cost Thin-film Flat Plate Photobioreactor for Microalgae Cultivation
Chenghu Yan,Qinghua Zhang,Shengzhang Xue,Zhongliang Sun,Xia Wu,Zhihui Wang,Yunming Lu,Wei Cong 한국생물공학회 2016 Biotechnology and Bioprocess Engineering Vol.21 No.1
In this study, a novel thin-film flat plate photobioreactor (FPPBR) mounted with baffles and a 61.2 m2 (2,000 L) photobioreactor system based on the FPPBR were developed. The flow of the fluid in the thinfilm photobioreactor was investigated by means of computational fluid dynamics (CFD). The cultivation of Chlorella sp. and Scenedesmus dimorphus in the thin-film FPPBR was carried out outdoors. The results showed that the flow of culture medium in different channels was uniform. In outdoor cultivation, the biomass productivity in the FPPBR with baffles was 25.2% higher than that in the FPPBR without baffles. In the pilot-scale FPPBR system, the maximum area productivity of Scenedesmus dimorphus reached 21.9 g/m2/day. When the service time of the photobioreactor was 1 and 3 years, the capital cost of the photobioreactor was 4.72 and 2.45 $ kgalgae, respectively. The results demonstrated that the thin-film FPPBR was cost effective, and it has the potential to be used for mass cultivation of microalgae.
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