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RISS 인기검색어
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- 저자 : Zhimin Pan (검색결과 4 건)
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Zhimin Pan,Yanhai Xi,Wei Huang,김긍년,이성,신동아,Kai Huang,Yu Chen,Zhongren Huang,Da He,하윤 대한척추신경외과학회 2019 Neurospine Vol.16 No.2
Objective: To investigate three-planar radiographic results and patient-reported outcomes (PROs) after correcting chronic atlantoaxial instability (AAI) by translaminar screw (TLS) and pedicle screw (PS) fixation, and to explore the potential association of atlantoaxial realignment with PRO improvements. Methods: Twenty-three patients who underwent C1 lateral mass screw (LMS)-C2 TLS and 29 who underwent C1 LMS-C2 PS with ≥2 years of follow-up were retrospectively analyzed. Three-planar (sagittal, coronal, and axial) radiographic parameters were measured. PROs including the Neck Disability Index (NDI), Japanese Orthopaedic Association (JOA) score and the Short Form 36 Physical Component Summary (SF-36 PCS) were documented. Factors potentially associated with PROs were identified. Results: The radiographic parameters significantly changed postoperatively except the C1–2 midlines’ intersection angle in the TLS group (p=0.073) and posterior atlanto-dens interval in both groups (p=0.283, p=0.271, respectively). The difference in bilateral odontoid lateral mass interspaces at last follow-up was better corrected in the TLS group than in the PS group (p=0.010). Postoperative PROs had significantly improved in both groups (all p<0.05). Thereinto, NDI at last follow-up was significantly lower in the TLS group compared with PS group (p=0.013). In addition, blood loss and operative time were obviously lesser in TLS group compared with PS group (p=0.010, p=0.004, respectively). Multivariable regression analysis revealed that a change in C1–2 Cobb angle was independently correlated to PROs improvement (NDI: β=-0.435, p=0.003; JOA score: β=0.111, p=0.033; SF-36 PCS: β=1.013, p=0.024, respectively), also age ≤40 years was independently associated with NDI (β=5.40, p=0.002). Conclusion: Three-planar AAI should be reconstructed by C1 LMS-C2 PS fixation, while sagittal or coronal AAI could be corrected by C1 LMS-C2 TLS fixation. PROs may improve after atlantoaxial reconstruction in patients with chronic AAI. The C1–2 Cobb angle is an independent predictor of PROs after correcting chronic AAI, as is age ≤40 years for postoperative NDI.
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Jiaying Pan,Zhimin Ou,Lan Tang,Hanbing Shi 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.5
Racemic 1-phenylethylamine was resolved by enantiomer selective acetylation using Fe3O4-chitosan microsphere (CTS)-glutaraldehyde-lipase in a solvent-free system under an alternating magnetic field. Magnetic chitosan microspheres (Fe3O4-CTS) were prepared via chemical co-precipitation and cross-linked with lipase using glutaraldehyde to form Fe3O4-CTS-glutaraldehyde-lipase particles. The magnetic, physicochemical, and textural characteristics of Fe3O4-CTS-glutaraldehyde-lipase particles were assessed by Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy. The optimal immobilization conditions were 2.4mg/mL lipase, 10mg/mL Fe3O4- CTS-glutaraldehyde, pH 8.5, 35 oC, 3 h. The loading amount of lipase and the specific activity got to 132mg/g carrier and 48U/g. The optimal reaction conditions of the acylation reaction using Fe3O4-CTS-glutaraldehyde-lipase were 300mmol/L 1-phenylethylamine, 150mg immobilized lipase, 2mL vinyl acetate, 12.6 ×g rotating speed, 40 oC, 8 h. The activity of the Fe3O4-CTS-glutaraldehyde-lipase particles and conversion were improved when they were exposed to an external alternating magnetic field. The optimum magnetic field was 12 Gs (500 Hz). The conversion, enantiomeric excess of (R)-N-(1-phenylethyl)acetamide, and E value reached 41.8%, 98.4%, and 264, respectively. Fe3O4-CTS-glutaraldehyde- lipase could be reused seven times. A kinetic model of the immobilized lipase-catalyzed resolution of 1- phenylethylamine was set up based on the ping-pong bi–bi mechanism. The kinetic constants were Vmax=1.62×102 mM/min, KA=2.84×104mM, and KB=5.8×101mM. The model data fit well with the experimental data.
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Ze-Hua Zhao,Feng-Zhi Xin,Yaqian Xue,Zhimin Hu,Yamei Han,Fengguang Ma,Da Zhou,Xiao-Lin Liu,Aoyuan Cui,Zhengshuai Liu,Yuxiao Liu,Jing Gao,Qin Pan,Yu Li,Jian-Gao Fan 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Microbial metabolites have emerged as critical components that mediate the metabolic effects of the gut microbiota. Here, we show that indole-3-propionic acid (IPA), a tryptophan metabolite produced by gut bacteria, is a potent anti-non-alcoholic steatohepatitis (NASH) microbial metabolite. Here, we demonstrate that administration of IPA modulates the microbiota composition in the gut and inhibits microbial dysbiosis in rats fed a high-fat diet. IPA induces the expression of tight junction proteins, such as ZO-1 and Occludin, and maintains intestinal epithelium homeostasis, leading to a reduction in plasma endotoxin levels. Interestingly, IPA inhibits NF-κB signaling and reduces the levels of proinflammatory cytokines, such as TNFα, IL-1β, and IL-6, in response to endotoxin in macrophages to repress hepatic inflammation and liver injury. Moreover, IPA is sufficient to inhibit the expression of fibrogenic and collagen genes and attenuate diet-induced NASH phenotypes. The beneficial effects of IPA on the liver are likely mediated through inhibiting the production of endotoxin in the gut. These findings suggest a protective role of IPA in the control of metabolism and uncover the gut microbiome and liver cross-talk in regulating the intestinal microenvironment and liver pathology via a novel dietary nutrient metabolite. IPA may provide a new therapeutic strategy for treating NASH.
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