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Zhi-Ning Huang,Han Liang,Hong Qiao,Bao-Rui Wang,Ning Qu,Hua Li,Run-Run Zhou,Li-Juan Wang,Shan-Hua Li,Fu-Nan Li 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.12
Guided by bioisosterism and pharmacokinetic parameters, we designed and synthesized a series of novel benzamide derivatives. Preliminary in vitro studies indicated that compounds 10b and 10j show significant inhibitory bioactivity in HepG2 cells (IC50 values of 0.12 and 0.13 μM, respectively). Compounds 10b and 10j induced the expression of HIF-1α protein and downstream target gene p21, and upregulated the expression of cleaved caspase-3 to promote tumor cells apoptosis.
Zhi-gang Tai,Yi-ren Zhu,Yi-bo Yuan,Jin Liu,Zhen-jie Li,Zhi-hua Liu,Kun-miao Wang 대한화학회 2020 Bulletin of the Korean Chemical Society Vol.41 No.3
In this work, a highly sensitive method using a colorimetric probe coupled to dispersive liquid?liquid microextraction (DLLME) was developed for the quantitative determination of dopamine (DA) in serum. The DA in serum was concentrated by DLLME to increase the detection sensitivity and reduce the matrix effects. After the DLLME process, a colorimetric probe of silver triangular nanoparticles (AgTNPs) was used to detect DA, which was based on the plasma transformation of AgTNPs caused by strong interactions with melamine (MA). The results showed that DA could inhibit the aggregation of AgTNPs induced by MA, resulting in the recovery of the surface plasmon resonance (SPR) peak of AgTNPs. Thus, the DLLME method followed by colorimetric probe detection of DA can be achieved. The parameters affecting the proposed method were optimized, under the optimal conditions, a linear calibration curve was obtained over a concentration range of 5 to 250?nM with a recovery from 94.4 to 101.3%. The detection limit was 1.6 nM (at an S/N ratio of 3). The present method was successfully applied to determine DA in human serum.
A new experimental technique on the tubular joints of spatial grid structures
Zhi-Hua Chen,Guo-Jun Sun,Zhi-Shan Luo 국제구조공학회 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.40 No.6
A new experimental technique was developed on the plate-inserted welded tubular joints of spatial grid structures. In the experimental technique, a microcomputer controlling instrument of moire intervention (MCIMI) was adopted. A test was designed on the plate-inserted welded tubular joints of spatial grid structures to show the effectiveness of the MCIMI technique. Both traditional electrical measuring technique and MCIMI technique were employed in the test. The test results showed that the MCIMI technique was feasible in the case of the complicated tests on steel structures. The MCIMI technique not only implemented the limitation of traditional electrical measuring technique, but also improved the accuracy of the test. According to the test results, we further examined the plate-inserted welded tubular joints in the cable-stayed spatial grids of the Binhai International Convention & Exhibition in Tianjin, China. The analysis showed the joints are safely designed with adequate conservatism. The research provided a new application of MCIMI in the field of large-scale structure engineering.
Synchronous Ectopic Pancreatoblastoma in a Child: A Case Report
Zhi-Hao Yang,Jian-Bo Gao,Song-Wei Yue,Xue-Hua Yang,Hua Guo 대한의학회 2011 Journal of Korean medical science Vol.26 No.6
Pancreatoblastoma is a rare primary pancreatic neoplasm of children that may arise in any portion of the pancreas. We report a case of a 3-yr-old boy who presented to with abdominal pain our hospital and a progressive bulge in his right abdomen. Biochemical evaluation and serum levels of tumoral markers were within reference limits. On the computed tomography, two tumors were found. One located in the head of the pancreas;however, a laparotomy revealed that the head of pancreas was compressed but normal. The other was in the left abdomen near the spleen and the tail of the pancreas. The diagnosis of two synchronous pancreatoblastoma originating from the omentum was confirmed by pathology. Therefore, a pancreatoblastoma should be considered when a large well-defined, lobulated, and heterogeneous mass is identified in the pancreas of children. In addition, an ectopic pancreatoblastoma should be considered when identified within or near the ectopic pancreatic tissue.
Zhi Yuan Fu,Hui Ling Xie,Jian Sheng Li,Yan Min Hu,Zong Hua Liu,Zhong You He,Ji Hua Tang 한국유전학회 2008 Genes & Genomics Vol.30 No.6
Thermo-sensitive genic male sterile (TGMS) lines can provide new options for hybrid seed production using "two-line" system. A set of F2 and BC1 populations derived from the cross between Qiong-6ms and Dan958 were employed to analyze the inheritance of a TGMS line Qiong-6ms and map the TGMS genes in maize. The results demonstrated that the sterility of Qiong-6ms was governed by two duplicative recessive genes, named tms1 and tms2. The gene tms1 was mapped to chromosome 5 linked with the SSR markers umc1355, umc2302 and umc1784 at a distance of 3.0 cM, 1.3 cM and 0.9 cM respectively; while tms2 was localized on chromosome 3, linked with SSR markers bnlg1605 (0.5 cM) and umc2050 (4.2 cM). These markers, which are tightly linked with the tms1 and tms2 genes, will be helpful for marker assisted selection of TGMS lines in maize.
Zhi-qiang Li,Dan Gui,Zhi-hua Sun,Jun-bo Zhang,Wen-zhi Zhang,Hui Zhang,Fei Guo,Chuangfu Chen 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.4
Brucellosis is a zoonotic disease that causes animal and human diseases. Vaccination is a major measure for prevention of brucellosis, but it is currently not possible to distinguish vaccinated animals from those that have been naturally infected. Therefore, in this study, we constructed the Brucella (B.) abortus 2380 wbkA mutant (2308DwbkA) and evaluated its virulence. The survival of 2308DwbkA was attenuated in murine macrophage (RAW 264.7) and BALB/c mice, and it induced high protective immunity in mice. The wbkA mutant elicited an anti-Brucella-specific immunoglobulin G response and induced the secretion of gamma interferon. Antibodies to 2308DwbkA could be detected in sera from mice, implying the potential for use of this protein as a diagnostic antigen. The WbkA antigen would allow serological differentiation between infected and vaccinated animals. These results suggest that 2308DwbkA is a potential attenuated vaccine against 16M. This vaccine will be further evaluated in sheep.
Zhi Ma,Chung-Bang Yun,Yan-Bin Shen,Feng Yu,Hua-Ping Wan,Yao-Zhi Luo 국제구조공학회 2019 Smart Structures and Systems, An International Jou Vol.24 No.4
A Bayesian dynamic linear model (BDLM) is presented for a data-driven analysis for response prediction and load effect separation of a revolving auditorium structure, where the main loads are self-weight and dead loads, temperature load, and audience load. Analyses are carried out based on the long-term monitoring data for static strains on several key members of the structure. Three improvements are introduced to the ordinary regression BDLM, which are a classificatory regression term to address the temporary audience load effect, improved inference for the variance of observation noise to be updated continuously, and component discount factors for effective load effect separation. The effects of those improvements are evaluated regarding the root mean square errors, standard deviations, and 95% confidence intervals of the predictions. Bayes factors are used for evaluating the probability distributions of the predictions, which are essential to structural condition assessments, such as outlier identification and reliability analysis. The performance of the present BDLM has been successfully verified based on the simulated data and the real data obtained from the structural health monitoring system installed on the revolving structure.
Zhi-kun Hu,Wei-hua Gui,Chun-hua Yang,Fei Xu 제어·로봇·시스템학회 2010 International Journal of Control, Automation, and Vol.8 No.2
A feature vectors extracting method for similarity measurement between a referenced sequence and an analyzed sequence is proposed. The referenced sequence and analyzed sequence are compressed into two wavelet matrices by Discrete Orthogonal Wavelet Transform (DOWT), respectively. A singular value vector and the multi-subspaces of the referenced matrix are derived from wavelet matrices by singular value decomposition (SVD). Consequently, a uniform subspace of which all sequences are mutual orthogonal can be constructed by serializing multi-subspaces, and the analyzed feature vectors can also be obtained by inner product transformation between analyzed sequence and all sequences derived from the multi-subspaces. The similarity is measured between the analyzed feature vector and the singular value vector of the referenced sequence. The simulation results show that the proposed method is improved in the dimension, accuracy and anti-noise ability with little sensitivity sacrifice.
Unusual Features in an Adult Pancreatic Hemangioma: CT and MRI Demonstration
Zhi-hua Lu,Mei Wu 대한영상의학회 2013 Korean Journal of Radiology Vol.14 No.5
Hemangiomas in the pancreas are very rare and only a few cases in adulthood have been reported in the literature. We describe a case of pancreatic hemangiomas in an adult with unique imaging findings. A 23-year-old woman visited the hospital for an incidentally detected pancreatic mass. CT and MRI revealed a multilocular cyst with fluid-fluid levels and no obvious enhancement. The patient underwent surgery and the mass was confirmed as a pancreatic hemangioma. The radiological features and differential diagnosis of this rare lesion are discussed.
A Simplified Numerical Model for Post-tensioned Steel Connections with Bolted Angles
Zhi-Hua Chen,Hongxing Li,Zhongwei Zhao,Haiqing Liu 한국강구조학회 2017 International Journal of Steel Structures Vol.17 No.4
Post-tensioned (PT) self-centering beam–column connections has been developed for its good seismic performance. Many researchers have investigated its mechanical behavior by numerical or experimental method. Prior researches have indicated that the analysis by elaborate FE models is very time consuming. To overcome this disadvantage, a simplified numerical model was established in this paper. The accuracy of results derived by this model was validated against prior investigations on interior PT connections with top-and-seat angles. Influence of initial PT force on mechanical behavior of PT connection was investigated. The Geometric and material nonlinearities, and strands can be considered in the modeling. A planar steel frame structure was established and hysteretic analysis was conducted. Results indicated that the computational cost can be greatly reduced by this model.