Development and Characterization of a Novel Fine-Grained W–Ni–Mn–Mo Alloys with La2O3 Addition Prepared Via Low-Temperature Sintering

Zhi‑Bo Li,Xin Lan,Guo‑Hua Zhang,Kuo‑Chih Chou 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.7

W–Ni–Mn heavy alloys are a kind of promising metal-matrix composites. A novel fully-compacted and fine-grained W–Ni–Mn–Mo composites with La2O3addition were fabricated in this work by the low-temperature sintering and vacuumheat-treatment techniques. W nanopowder synthesized by a two-stage reduction approach was employed as raw material. The heat-treated alloys contained equiaxed W grains (only 7.43 μm) surrounded by a Ni–Mn-based matrix phase, whileLa2O3particles were dispersed at grain boundaries. The 91 W–4.2Ni–2.8Mn–2Mo–1La2O3 alloy sintered at 1200 °C for2 h exhibited superior comprehensive properties, with a maximum tensile strength of ~ 904 MPa, elongation of ~ 19.8% andhardness of ~ 452 HV1. Additions of Mo and La2O3contribute to triggering the fine-grained strengthening, oxide dispersionstrengthening and solid solution strengthening mechanisms.

Immunization of BALB/c mice with Brucella abortus 2308DwbkA confers protection against wild-type infection

Zhi-qiang Li,Dan Gui,Zhi-hua Sun,Jun-bo Zhang,Wen-zhi Zhang,Hui Zhang,Fei Guo,Chuangfu Chen 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.4

Brucellosis is a zoonotic disease that causes animal and human diseases. Vaccination is a major measure for prevention of brucellosis, but it is currently not possible to distinguish vaccinated animals from those that have been naturally infected. Therefore, in this study, we constructed the Brucella (B.) abortus 2380 wbkA mutant (2308DwbkA) and evaluated its virulence. The survival of 2308DwbkA was attenuated in murine macrophage (RAW 264.7) and BALB/c mice, and it induced high protective immunity in mice. The wbkA mutant elicited an anti-Brucella-specific immunoglobulin G response and induced the secretion of gamma interferon. Antibodies to 2308DwbkA could be detected in sera from mice, implying the potential for use of this protein as a diagnostic antigen. The WbkA antigen would allow serological differentiation between infected and vaccinated animals. These results suggest that 2308DwbkA is a potential attenuated vaccine against 16M. This vaccine will be further evaluated in sheep.

Colorimetric Probe Coupled to Dispersive Liquid–Liquid Microextraction for Determination of Dopamine in Serum

Zhi-gang Tai,Yi-ren Zhu,Yi-bo Yuan,Jin Liu,Zhen-jie Li,Zhi-hua Liu,Kun-miao Wang 대한화학회 2020 Bulletin of the Korean Chemical Society Vol.41 No.3

In this work, a highly sensitive method using a colorimetric probe coupled to dispersive liquid?liquid microextraction (DLLME) was developed for the quantitative determination of dopamine (DA) in serum. The DA in serum was concentrated by DLLME to increase the detection sensitivity and reduce the matrix effects. After the DLLME process, a colorimetric probe of silver triangular nanoparticles (AgTNPs) was used to detect DA, which was based on the plasma transformation of AgTNPs caused by strong interactions with melamine (MA). The results showed that DA could inhibit the aggregation of AgTNPs induced by MA, resulting in the recovery of the surface plasmon resonance (SPR) peak of AgTNPs. Thus, the DLLME method followed by colorimetric probe detection of DA can be achieved. The parameters affecting the proposed method were optimized, under the optimal conditions, a linear calibration curve was obtained over a concentration range of 5 to 250?nM with a recovery from 94.4 to 101.3%. The detection limit was 1.6 nM (at an S/N ratio of 3). The present method was successfully applied to determine DA in human serum.

A damage localization method based on the singular value decomposition (SVD) for plates

Zhi-Bo Yang,Jin-Tao Yu,Shao-Hua Tian,Xue-Feng Chen,Guan-Ji Xu 국제구조공학회 2018 Smart Structures and Systems, An International Jou Vol.22 No.5

Boundary effect and the noise robustness are the two crucial aspects which affect the effectiveness of the damage localization based on the mode shape measurements. To overcome the boundary effect problem and enhance the noise robustness in damage detection, a simple damage localization method is proposed based on the Singular Value Decomposition (SVD) for the mode shape of composite plates. In the proposed method, the boundary effect problem is addressed by the decomposition and reconstruction of mode shape, and the noise robustness in enhanced by the noise filtering during the decomposition and reconstruction process. Numerical validations are performed on plate-like structures for various damage and boundary scenarios. Validations show that the proposed method is accurate and effective in the damage detection for the two-dimensional structures.

Astilbin alleviates sepsis-induced acute lung injury by inhibiting the expression of macrophage inhibitory factor in rats

Hong-bo Zhang,Li-chao Sun,Li-da Zhi,Qian-kuan Wen,Zhi-wei Qi,Sheng-tao Yan,Wen Li,Guo-qiang Zhang 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.10

Sepsis is a systemic inflammatory responsesyndrome caused by severe infections. Astilbin is a dihydroflavonolderivative found in many medicinal and foodplants with multiple pharmacological functions. To investigatethe effects of astilbin on sepsis-induced acute lunginjury (ALI), cecal ligation and puncture was performed onrats to establish a sepsis-induced ALI model; these ratswere then treated with astilbin at different concentrations. Lung injury scores, including lung wet/dry ratio, proteinleakage, myeloperoxidase activity, and inflammatory cellinfiltration were determined to evaluate the effects ofastilbin on sepsis-induced ALI. We found that astilbintreatment significantly attenuates sepsis-induced lunginjury and improves survival rate, lung injury scores, lungwet/dry ratio, protein leakage, myeloperoxidase activity,and inflammatory cell infiltration. Astilbin treatment alsodramatically decreased the production of inflammatorycytokines and chemokines in bronchoalveolar lavage fluid. Further, astilbin treatment inhibited the expression andproduction of macrophage inhibitory factor (MIF), whichinhibits the inflammatory response. Collectively, these datasuggest that astilbin has a protective effect against sepsisinducedALI by inhibiting MIF-mediated inflammatoryresponses. This study provides a molecular basis for astilbinas a new medical treatment for sepsis-induced ALI.

The Analysis on the present situation and problems of augmented reality books for children

Ding Zhi Bo,Seung-keun Song,Hun Choi,Eunyoung Choi 한국콘텐츠학회 2018 한국콘텐츠학회 ICCC 논문집 Vol.2018 No.12

서비스디자인 개선을 위한 사례분석

딩즈보(Zhi-Bo Ding),송승근(Seung-Keun Song) 한국콘텐츠학회 2018 한국콘텐츠학회논문지 Vol.18 No.11

본 연구는 해외 관광객들의 문화욕구를 분석하고 감천문화마을에서 제공할 수 있는 문화 서비스 요소를 조사하여 문화 서비스를 개선하는 구체적인 방책을 제시하고 궁극적으로 감천문화마을을 우수한 국제 관광 문화 브랜드를 육성하는 것을 목적으로 한다. 외국관광객들의 문화욕구가 무엇인지 알아보기 위해 도시 재생이 진행된 곳 가운데 감천문화마을을 대상으로 사례 연구를 수행하였다. 연구수행 기간은 4개월이었으며 6개국 외국관광객을 대상으로 문헌조사, 인터뷰, 참여관찰을 통해 기초자료를 수집하였다. 자료 분석은 도시재생, 문화욕구, 서비스 디자인 이론을 토대로 내용분석을 실시하였다. 본 연구는 감천문화마을의 5가지 문화 서비스 목표를 제시하였다. 첫째, 현지 특색문화의 전시 및 홍보, 둘째, 문화상품의 개발과 판매, 셋째, 좋은 관광이미지 부각, 넷째, 특이한 먹거리 제공, 다섯째, 문화체험 최적화이다. 본 연구를 통해 감천문화마을에 대한 문화서비스 향상에 도움을 줄 것으로 기대된다. The purpose of this study is to analyze the cultural needs of foreign tourists, to investigate the cultural service elements that can be provided in ‘Gamcheon Culture Village’, to suggest concrete policy to improve cultural services, and ultimately to cultivate excellent international tourism culture brands in ‘Gamcheon Culture Village’. In order to find out the cultural needs of foreign tourists, we conducted a case study on ‘Gamcheon Culture Village’ among the places where the urban regeneration proceeded. The study period was four months, and basic data were collected from foreign tourists from six countries through literature reviews, interviews and participation observation. Analysis of data was based on urban regeneration, cultural desire and service design theory, and we conducted content analysis. This study presented five cultural service goals of ‘Gamcheon Culture Village’. First, it displays and promotes local characteristic culture. Second, it develops and sells cultural products. Third, it brings up a good tourist image. Fourth, it provides an unusual food. Fifth, cultural experience optimization. Through this study, it is expected to help improve the cultural service of ‘Gamcheon Culture Village’.

VALUE DISTRIBUTION AND UNIQUENESS ON q-DIFFERENCES OF MEROMORPHIC FUNCTIONS

Huang, Zhi-Bo Korean Mathematical Society 2013 대한수학회보 Vol.50 No.4

In this paper, by using the $q$-difference analogue of lemma on the logarithmic derivative lemma to re-establish some estimates of Nevanlinna characteristics of $f(qz)$, we deal with the value distribution and uniqueness of certain types of $q$-difference polynomials.

PROPERTIES ON q-DIFFERENCE RICCATI EQUATION

Huang, Zhi-Bo,Zhang, Ran-Ran Korean Mathematical Society 2018 대한수학회보 Vol.55 No.6

In this paper, we investigate a certain type of q-difference Riccati equation in the complex plane. We prove that q-difference Riccati equation possesses a one parameter family of meromorphic solutions if it has three distinct meromorphic solutions. Furthermore, we find that all meromorphic solutions of q-difference Riccati equation and corresponding second order linear q-difference equation can be expressed by q-gamma function if this q-difference Riccati equation admits two distinct rational solutions and $q{\in}{\mathbb{C}}$ such that 0 < ${\mid}q{\mid}$ < 1. The growth and value distribution of differences of meromorphic solutions of q-difference Riccati equation are also treated.

In Vitro and in Vivo Antitumor Evaluation of Berbamine for Lung Cancer Treatment

Hou, Zhi-Bo,Lu, Kai-Jin,Wu, Xiao-Li,Chen, Cong,Huang, Xin-En,Yin, Hai-Tao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4

Purpose: Lung cancer, one of the most frequently diagnosed cancers in the world, is characterized by relatively high morbidity and mortality. Berbamine (BER) has been initially reported to exert anti-proliferative effects against a series of cancers. Methods: In this study the in vitro cytotoxicity of BER was measured by MTT assay. In vivo anti-cancer efficacy of BER was assessed in A549 xenografts. Results: Cytotoxicity tests showed dose-dependent cell growth inhibition effects of BER against A549 cells. Moreover, BER significantly reduced the growth of lung cancer in a dose-dependent manner in nude mice with prolonged survival time. Conclusion: Therefore, BER might be in herbal medicine for cancer therapy and further efforts are needed to explore therapeutic strategies.