Mycosis Fungoides and Variants of Mycosis Fungoides: A Retrospective Study of 93 Patients in a Chinese Population at a Single Center

( Yixin Luo ),( Zhaorui Liu ),( Jie Liu ),( Yuehua Liu ),( Wei Zhang ),( Yan Zhang ) 대한피부과학회 2020 Annals of Dermatology Vol.32 No.1

Background: Mycosis fungoides (MF) is the most common types of cutaneous T cell lymphoma. It typically presents with erythematous patches and plaques in the early stage and tumors and extracutaneous involvement with possibly fatal outcomes in the late stage. To facilitate early and accurate diagnosis of MF, it is essential to be knowledgeable of classic and variants of this disease. However, there is limited published data in the Chinese population. Objective: To characterize our patient group and to provide additional insight into these malignancies. Methods: Patients diagnosed with mycosis fungoides and its variants from October 2012 to January 2018 were retrospectively analyzed. Disease-specific survival (DSS) rate and curve according to early and advanced stages were also calculated. Results: The mean age at diagnosis of ninety-three MF patients was 38.9±1.73 years (range: 6∼77). Forty-five males (48.4%) and 48 females (51.6 %) were included in this study. The DSS rate of early- stage MF was 98.6%, while that of advanced stage MF was 88.9%. There was a significant difference in DSS rate between early stage and advanced stage MF (p=0.042, logrank test). The median age of 10 patients with hypopigmented MF (hMF) was 10.5 years (range: 6∼28). The age of hMF was younger than that of classical MF patients (p <0.05). Conclusion: Early-stage MF has a better prognosis than advanced stage and hMF affects younger people than classic MF among Chinese. This study provides an insight into mycosis fungoides and its variants in a Chinese population. (Ann Dermatol 32(1) 14∼20, 2020)

Influence of Atmospheric Turbulence Channel on a Ghost-imaging Transmission System

Kaimin Wang,Zhaorui Wang,Leihong Zhang,Yi Kang,Hualong Ye,Jiafeng Hu,Jiaming Xu 한국광학회 2020 Current Optics and Photonics Vol.4 No.1

We research a system of compressed-sensing computational ghost imaging (CSCGI) based on the intensity fluctuation brought by turbulence. In this system, we used the gamma-gamma intensity-fluctuation model, which is commonly used in transmission systems, to simulate the CSCGI system. By setting proper values of the parameters such as transmission distance, refractive-index structure parameter, and sampling rates, the peak signal-to-noise ratio (PSNR) performance and bit-error rate (BER) performance are obtained to evaluate the imaging quality, which provides a theoretical model to further research the ghost-imaging algorithm.

Flexural Behavior and Prediction Model of Basalt Fiber/Polypropylene Fiber-Reinforced Concrete

Qiang Fu,Zhaorui Zhang,Wenrui Xu,Xu Zhao,Lu Zhang,Yan Wang,Ditao Niu 한국콘크리트학회 2022 International Journal of Concrete Structures and M Vol.16 No.5

The flexural behavior of basalt fiber (BF)/polypropylene fiber (PF)-reinforced concrete (BPRC) was investigated. When the content of BF and PF is 0.1%, the addition of fibers increases the compressive strength of concrete. A BF content of 0.1% has the most obvious effect on improving the compressive strength, but a hybrid fiber content of 0.2% exhibits a negative effect on the compressive strength. The addition of BF and PF can increase the flexural strength and the expansion tortuosity of the fracture cracks, thus enhancing the ductility of concrete. The hybrid fibers with content of 0.1% are most beneficial to increase the flexural strength. However, the ductility of concrete and the tortuosity of fracture crack decrease with the matrix strength, and the improvement proportion of fibers on the flexural strength also decreases. When the BF and PF are mixed, compared to the case of single fiber added, there is no significant change in the damage of BF, whereas the damage of PF is more severe. The flexural toughness index FTδ effectively characterizes the change in the flexural toughness of BPRC. The hybrid fiber contents of 0.1% and 0.2% exhibit the most significant improving effect on FT-l/600 and FT-l/150, respectively. Considering the influence of fibers on the compressive strength, flexural strength and flexural toughness of concrete, a hybrid content of 0.1% is the optimal choice of fiber content. A prediction model for flexural strength of BPRC is proposed based on the composite material theory.

Influence of Atmospheric Turbulence Channel on a Ghost-imaging Transmission System

Wang, Kaimin,Wang, Zhaorui,Zhang, Leihong,Kang, Yi,Ye, Hualong,Hu, Jiafeng,Xu, Jiaming Optical Society of Korea 2020 Current Optics and Photonics Vol.4 No.1

We research a system of compressed-sensing computational ghost imaging (CSCGI) based on the intensity fluctuation brought by turbulence. In this system, we used the gamma-gamma intensity-fluctuation model, which is commonly used in transmission systems, to simulate the CSCGI system. By setting proper values of the parameters such as transmission distance, refractive-index structure parameter, and sampling rates, the peak signal-to-noise ratio (PSNR) performance and bit-error rate (BER) performance are obtained to evaluate the imaging quality, which provides a theoretical model to further research the ghost-imaging algorithm.

A Ghost-Imaging System Based on a Microfluidic Chip

Kaimin Wang,Xiaoxuan Han,Hualong Ye,Zhaorui Wang,Leihong Zhang,Jiafeng Hu,Meiyong Xu,Xiangjun Xin,Dawei Zhang 한국광학회 2021 Current Optics and Photonics Vol.5 No.2

Microfluidic chip technology is a research focus in biology, chemistry, and medicine, for example. However, microfluidic chips are rarely applied in imaging, especially in ghost imaging. Thus in this work we propose a ghost-imaging system, in which we deploy a novel microfluidic chip modulator (MCM) constructed of double-layer zigzag micro pipelines. While in traditional situations a spatial light modulator (SLM) and supporting computers are required, we can get rid of active modulation devices and computers with this proposed scheme. The corresponding simulation analysis verifies good feasibility of the scheme, which can ensure the quality of data transmission and achieve convenient, fast ghost imaging passively.

RUNX1 Upregulation Causes Mitochondrial Dysfunction via Regulating the PI3K-Akt Pathway in iPSC from Patients with Down Syndrome

Jingbin Yan,Yanna Liu,Yuehua Zhang,Zhaorui Ren,Fanyi Zeng 한국분자세포생물학회 2023 Molecules and cells Vol.46 No.4

Down syndrome (DS) is the most common autosomal aneuploidy caused by trisomy of chromosome 21. Previous studies demonstrated that DS affected mitochondrial functions, which may be associated with the abnormal development of the nervous system in patients with DS. Runt-related transcription factor 1 (RUNX1) is an encoding gene located on chromosome 21. It has been reported that RUNX1 may affect cell apoptosis via the mitochondrial pathway. The present study investigated whether RUNX1 plays a critical role in mitochondrial dysfunction in DS and explored the mechanism by which RUNX1 affects mitochondrial functions. Expression of RUNX1 was detected in induced pluripotent stem cells of patients with DS (DS-iPSCs) and normal iPSCs (N-iPSCs), and the mitochondrial functions were investigated in the current study. Subsequently, RUNX1 was overexpressed in N-iPSCs and inhibited in DS-iPSCs. The mitochondrial functions were investigated thoroughly, including reactive oxygen species levels, mitochondrial membrane potential, ATP content, and lysosomal activity. Finally, RNA-sequencing was used to explore the global expression pattern. It was observed that the expression levels of RUNX1 in DS-iPSCs were significantly higher than those in normal controls. Impaired mitochondrial functions were observed in DS-iPSCs. Of note, overexpression of RUNX1 in N-iPSCs resulted in mitochondrial dysfunction, while inhibition of RUNX1 expression could improve the mitochondrial function in DS-iPSCs. Global gene expression analysis indicated that overexpression of RUNX1 may promote the induction of apoptosis in DS-iPSCs by activating the PI3K/Akt signaling pathway. The present findings indicate that abnormal expression of RUNX1 may play a critical role in mitochondrial dysfunction in DS-iPSCs.