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      • KCI등재

        Effects of Aqueous Extract of Schizandrae Fructus on Lead-Induced Change of Monoamine Neurotransmitters in Hippocampus

        Zhao,,Rong,Jie,Zhao,,Zheng,Lin,Zhao,,Xiu,Feng,Zhao,,Guang,Wen,Li,,Meng,Quan,Wu,,Yi,Yan,Li,,Jing,Qiu,Guan,,Li,Xin,Kim,,Sang-Chan The Korean Medicine Society for the Herbal Formula 2009 大韓韓醫學方劑學會誌 Vol.17 No.2

        The effects of aqueous extract of Schizandrae Fructus (AESC) on lead (Pb)-induced changes of monoamine neurotransmitters in the hippocampus (HIP) of adult rats were investigated. Male Sprague-Dawley rats were received intraperitoneal (i.p.) administration of Pb acetate (5 mg/kg/d) for 28 days and sacrificed 7 days after the last administration. Concentrations of norepinephrine (NE), dopamine (DA), serotonin (5-HT), 5-hydroxyindole acetic acid (5-HIAA) in HIP were measured by HPLC. There were significant decreases of NE, DA, 5-HT and 5-HIAA in Pb treated rats (P < 0.05), while pretreatment with AESC (100 mg/kg/d or 300 mg/kg/d, p.o., 2 h before Pb) greatly inhibited the decrease of monoamine transmitters, respectively (P < 0.05). Also, AESC (300 mg/kg/d) significantly increased the reduction of glutathione contents and superoxide dismutase activities in HIP induced by chronic Pb. These results suggest that AESC ameliorates Pb-induced depletion of monoamine neurotransmitters in HIP through its antioxidant activity.

      • SCOPUSKCI등재

        Effects of Aqueous Extract of Schizandra Chinensis Fruit on Cadmium-Induced Change of Monoamine Neurotransmitters in Rats

        Zhao,,Zheng,Lin,Zhao,,Guang,Wen,Li,,Li,Li,,Meng,Quan,Guan,,Li,Xin,Yang,,Xu,Dong,Li,,Hou,Zhong,Lin,,Feng,Lee,,Jong-Rok,Zhao,,Rong,Jie The Korean Society of Toxicology Korea Environment 2009 Toxicological Research Vol.26 No.1

        The effects of aqueous extract of Schizandra Chinensis Fruit (AESC) on cadmium-induced changes of monoamine neurotransmitters in the different brain regions of adult rats were investigated. Male rats were received intraperitoneal (i.p.) administration of CdCl2 (0.6 mg/kg/d) for 21 days and sacrificed 7 days after the last administration. Concentrations of norepinephrine (NE), dopamine (DA) in striatum and serotonin (5-HT), 5-hydroxyindole acetic acid (5-HIAA) in cortex were measured by HPLC. There were significant decreases of NE, DA, 5-HT and 5-HIAA in Cd intoxicated rats (P < 0.05), while pretreatment with AESC (20 mg/kg/d or 60 mg/kg/d, p.o., 30 min before $CdCl_2$) greatly inhibited the decrease of monoamine transmitters, respectively (P < 0.05). Also, AESC significantly increased the reduction of glutathione contents and superoxide dismutase activities in cortex induced by $CdCl_2$. These results suggest that AESC ameliorates Cd-induced depletion of monoamine neurotransmitters in brain through its antioxidant activity.

      • KCI등재SCOPUS
      • Modulation of Drug Resistance in Ovarian Cancer Cells by Inhibition of Protein Kinase C-alpha (PKC-α) with Small Interference RNA (siRNA) Agents

        Zhao,,Li-Jun,Xu,,Heng,Qu,,Jun-Wei,Zhao,,Wan-Zhou,Zhao,,Yi-Bing,Wang,,Jin-Hua Asian Pacific Organization for Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

        Objective: To determine whether silence of $PKC-{\alpha}$ expression by small interference RNA (siRNA) might regulate MDR1 expression and reverse chemoresistance of ovarian cancer. Methods: We measured gene and protein expression of MDR1 and $PKC-{\alpha}$ in ovarian cancer cells and assessed their correlation with cell drug resistance. We also examined whether blocking $PKC-{\alpha}$ by RNA interference (RNAi) affected MDR1 expression and reversed drug resistance in drug sensitivity tests. Results: The drug resistance cell lines, OV1228/DDP and OV1228/Taxol, had higher gene and protein expression of MDR1 and $PKC-{\alpha}$ than their counterpart sensitive cell line, OV1228. SiRNA depressed $PKC-{\alpha}$ gene protein expression, as well as MDR1 and protein expression and improved the drug sensitivity in OV1228/DDP and OV1228/Taxol cells. Conclusion: These results indicated that decreasing $PKC-{\alpha}$ expression with siRNA might be an effective method to improve drug sensitivity in drug resistant cells with elevated levels of $PKC-{\alpha}$ and MDR1. A new siRNA-based therapeutic strategy targeting $PKC-{\alpha}$ gene could be designed to overcome the chemoresistance of ovarian cancer.

      • Optimization of Reference Genes for Normalization of the Quantitative Polymerase Chain Reaction in Tissue Samples of Gastric Cancer

        Zhao,,Lian-Mei,Zheng,,Zhao-Xu,Zhao,,Xiwa,Shi,,Juan,Bi,,Jian-Jun,Pei,,Wei,Feng,,Qiang Asian Pacific Organization for Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14

        For an exact comparison of mRNA transcription in different samples or tissues with real time quantitative reverse transcription-polymerase chain reaction (qRT-PCR), it is crucial to select a suitable internal reference gene. Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and beta-actin (ACTB) have been frequently considered as house-keeping genes to normalize for changes in specific gene expression. However, it has been reported that these genes are unsuitable references in some cases, because their transcription is significantly variable under particular experimental conditions and among tissues. The present study was aimed to investigate which reference genes are most suitable for the study of gastric cancer tissues using qRT-PCR. 50 pairs of gastric cancer and corresponding peritumoral tissues were obtained from patients with gastric cancer. Absolute qRT-PCR was employed to detect the expression of GAPDH, ACTB, RPII and 18sRNA in the gastric cancer samples. Comparing gastric cancer with corresponding peritumoral tissues, GAPDH, ACTB and RPII were obviously upregulated 6.49, 5.0 and 3.68 fold, respectively. Yet 18sRNA had no obvious expression change in gastric cancer tissues and the corresponding peritumoral tissues. The expression of GAPDH, ${\beta}$-actin, RPII and 18sRNA showed no obvious changes in normal gastric epithelial cells compared with gastric cancer cell lines. The carcinoembryonic antigen (CEA), a widely used clinical tumor marker, was used as a validation gene. Only when 18sRNA was used as the normalizing gene was CEA obviously elevated in gastric cancer tissues compared with peritumoral tissues. Our data show that 18sRNA is stably expressed in gastric cancer samples and corresponding peritumoral tissues. These observations confirm that there is no universal reference gene and underline the importance of specific optimization of potential reference genes for any experimental condition.

      • KCI등재

        Metastasis associated genomic aberrations in stage II rectal cancer

        Hong,Zhao,Zhi-Zhou,Shi,Rui,Jiang,Dong-Bing,Zhao,Hai-Tao,Zhou,Jian-Wei,Liang,Xin-Yu,Bi,Jian-Jun,Zhao,Zhi-Yu,Li,Jian-Guo,Zhou,Zhen,Huang,Ye-Fan,Zhang,Jian,Wang,Xin,Xu,Yan,Cai,Ming-Rong,Wang,Yu,Zhang 한국유전학회 2016 Genes & Genomics Vol.38 No.11

        Genomic aberrations of rectal carcinoma, especially DNA copy number changes associated with metastasis were largely unclear. We aim to identify the metastasis associated biomarkers in stage II rectal cancer. Formalin-fixed, paraffin-embedded primary tumor tissues of stage II rectal carcinoma were analyzed by array-based comparative genomic hybridization, and genomic aberrations were identified by Genomic Workbench and SAM software. Copy number changes and mRNA expressions were validated by Real-time PCR in an independent rectal cancer samples. The results showed that the most frequent gains in stage II rectal cancer were at 1q21.2-q23.1, 3p21.31, 11q12.2-q23.3, 12q24.11-q24.31, 12q13.11-q14.1 and losses in 18q11.2-q23, 17q21.33-q22, 13q31.1-q31.3, 21q21.1-q21.3, 8p23.3-p23.1 and 4q22.1-q23. Twenty-two amplifications and five homozygous deletions were also identified. We further found that S100A1 (1q21.3-q23.1), MCM7 (7q22.1) and JUND (19p13.11) were amplified and overexpressed in stage II rectal cancer. Interestingly, the genomic aberrations affected 14 signaling pathways including VEGF signaling pathway and fatty acid metabolism. Most importantly, loss of 13q31.1-q34 and gain of 1q44 were associated with distant metastasis. Our results indicated that these metastasis associated genomic changes may be useful to reveal the pathogenesis of rectal cancer metastasis and identify candidate biomarkers.

      • KCI등재

        Effects of Aqueous Extract of Schizandra Chinensis Fruit on Cadmium-Induced Change of Monoamine Neurotransmitters in Rats

        Zheng,Lin,Zhao,Guang,Wen,Zhao,Li,Li,Meng,Quan,Li,Li,Xin,Guan,Xu,Dong,Yang,Hou,Zhong,Li,Feng,Lin,Jong,Rok,Lee,Rong,Jie,Zhao 한국독성학회 2009 Toxicological Research Vol.25 No.1

        The effects of aqueous extract of Schizandra Chinensis Fruit (AESC) on cadmium-induced changes of monoamine neurotransmitters in the different brain regions of adult rats were investigated. Male rats were received intraperitoneal (i.p.) administration of CdCl₂ (0.6 ㎎/㎏/d) for 21 days and sacrificed 7 days after the last administration. Concentrations of norepinephrine (NE), dopamine (DA) in striatum and serotonin (5-HT), 5-hydroxyindole acetic acid (5-HIAA) in cortex were measured by HPLC. There were significant decreases of NE, DA, 5-HT and 5-HIAA in Cd intoxicated rats (P < 0.05), while pretreatment with AESC (20 ㎎/㎏/d or 60 mg/kg/d, p.o., 30 min before CdCl₂) greatly inhibited the decrease of monoamine transmitters, respectively (P < 0.05). Also, AESC significantly increased the reduction of glutathione contents and superoxide dismutase activities in cortex induced by CdCl₂. These results suggest that AESC ameliorates Cd-induced depletion of monoamine neurotransmitters in brain through its antioxidant activity.

      • Research on Terrain Reconstruction of Twin Sequence Images in Lunar Exploration

        Wang,Wei,Zhao,Wenbin,Zhao,Zhengxu 보안공학연구지원센터 2014 International Journal of Signal Processing, Image Vol.7 No.5

        The detectors are an important tool in deep space exploration; they can provide a large number of images which contain the ground environment information of celestial body. Bythree-dimensional reconstruction, terrain information can be extracted from these images, such as elevation data and texture data. This paper focuses on an adaptive terrain reconstruction for sequence image. A method, which calculate Binocular geometric model with matching measures of matching points and random sample consensus algorithm, is proposed. On the basic of this method, a densepoints matching method based on epipolar and homography constraints is presented. Besides the selection method of reconstruction image and the terrain reconstruction flow are discussed. The proposed adaptive terrain reconstruction satisfies the automation and real time requirement of some terrain reconstruction task, such as landing filed selection in detector landing, and is experiment and applied into sequence image of detector ChangE III's landing camera, so as to ensure the safety of detector landing.

      • SCIESCOPUSKCI등재후보

        Simultaneously evolutionary optimization of several natural frequencies of a two dimensional structure

        Zhao,,Chongbin,Steven,,G.P.,Xie,,Y.M. Techno-Press 1999 Structural Engineering and Mechanics, An Int'l Jou Vol.7 No.5

        This paper presents a solution method, which can be regarded as the further extension of the generalized evolutionary method (Zhao et al. 1998a), for the simultaneous optimization of several different natural frequencies of a structure in general and a two dimensional structure in particular. The main function of the present method is to optimize the topology of a structure so as to simultaneously make several different natural frequencies of interest to be of the corresponding different desired values for the target structure. In order to develop the present method, the new contribution factor of an element is proposed to consider the contribution of an element to the gaps between the currently calculated values for the different natural frequencies of interest and their corresponding desired values in a weighted manner. Using this new contribution factor of an element, the most inefficiently used material can be detected and removed gradually from the design domain of a structure. Through applying the present method to optimize two and three different natural frequencies of a two dimensional structure, it has been demonstrated that it is possible and applicable to use the generalized evolutionary method for tackling the simultaneous optimization of several different natural frequencies of a structure in the structural design.

      • SCISCIESCOPUS

        Free-Standing Single-Atom-Thick Iron Membranes Suspended in Graphene Pores

        Zhao,,Jiong,Deng,,Qingming,Bachmatiuk,,Alicja,Sandeep,,Gorantla,Popov,,Alexey,Eckert,,,rgen,,mmeli,,Mark,H. American Association for the Advancement of Scienc 2014 Science Vol.343 No.6176

        <P><B>Iron in Graphene</B></P><P>Carbon or other covalently bonded materials, like boron nitride, can form two-dimensional sheets because of the strong bonding between the atoms. In contrast, metals share electrons in a three-dimensional delocalized way, and this could preclude the formation of thin stable sheets. Nevertheless, <B>Zhao <I>et al.</I></B> (p. 1228) observed pure iron membranes suspended across the pores in a graphene sheet. This phenomenon was discovered when an iron chloride solution, used to process the graphene, decomposed to form pure iron films across the pores.</P>

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