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- 저자 : Zachary Brown (검색결과 2 건)
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Brown Fat and Metabolic Health: The Diverse Functions of Dietary Components
Takeshi Yoneshiro,Zachary Brown 대한내분비학회 2024 Endocrinology and metabolism Vol.39 No.6
Brown and beige adipocytes utilize a variety of substrates for cold-induced thermogenesis, contributing to the clearance of metabolites in circulation and, consequently, metabolic health. Food-derived compounds that exhibit agonistic activity at temperature-sensitive transient receptor potential channels may serve as cold mimics to elicit thermogenesis and substrate utilization in brown adipose tissue (BAT). In addition to fatty acids and glucose, branched-chain amino acids (BCAAs), which are essential amino acids obtained from foods, are actively catabolized in BAT through mitochondrial BCAA carrier (MBC). The relative contribution of BCAAs to fueling the tricarboxylic acid cycle as a substrate (i.e., anaplerosis) is estimated to be relatively small, yet BCAA catabolism in BAT exerts a critical role in systemic insulin sensitivity. The nature of this apparent tension remained unclear until the recent discovery that active BCAA catabolism in BAT through MBC is critical for the synthesis of metabolites such as glutathione, which is delivered to the liver to improve hepatic insulin sensitivity through redox homeostasis. Novel mechanistic insights into the control of BAT function and systemic metabolism reveal the therapeutic potential of food-derived compounds for improving metabolic flexibility and insulin sensitivity.
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Melvin Lewis,Kenon A. Brown,Andrew C. Billings,Zachary W. Arth 글로벌지식마케팅경영학회 2022 Journal of Global Sport Management Vol.7 No.4
This study explored causal relationships and moderation effects in the context of the National Football League (NFL; American football), employing 732 respondents from a pair of nationally representative samples to determine the degree of similarity or difference between feelings about the United States as it relates to American consumption of the 2018 Winter Olympics and the 2018 NFL season. Media consumption’s influence on one’s feelings of nationalism was stronger for Winter Olympic fans compared to NFL fans, yet no differences were detected on patriotism and internationalism factors. Academicians and sport marketers should regard these findings as a warrant for considering exploring cause-related sports marketing (CRSM) techniques. Differences in nationalism findings suggest that the comparisons between nations are exclusively an Olympics-based phenomena while the National Football League seems to be much more insular in that regard.
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