Combination antibacterial therapy against ß-lactam drug resistance

Shin, Wooshik ProQuest LLC 2016 국내박사

Electron beam induced isotropic decomposition of nano ice

박지수 Korea Advanced Institute of Science and Technology 2019 국내석사

Development of the Near Infrared Camera System for Astronomical Application

문봉곤 충남대학교 대학원 2010 국내박사

In this paper, I describe the domestic development of near infrared camera systems for the ground telescope and the space satellite. These systems are the first infrared instruments made for astronomical observation in Korea. The Korea Astronomy and Space science Institute (KASI) Near Infrared Camera System (KASINICS) was developed to be installed on the 1.8m telescope of the Bohyunsan Optical Astronomy Observatory (BOAO) in Korea. KASINICS is equipped with a 512☓512 InSb array (Aladdin III Quadrant, Raytheon Co.) enable L band observations as well as J, H, and Ks bands. The field-of-view (FOV) of the array is 3.3'☓3.3' with a resolution of 0.39"/pixel. It employs an Offner relay optical system providing a cold stop to eliminate thermal background emission from the telescope structures. Most parts of the camera including the mirrors were manufactured from the same ingot of aluminum alloy to ensure homologous contraction from room temperature to 80K. A readout electronics system was also developed for the array detector. Based on the preliminary results from the test observation, limiting magnitudes are J=17.6, H=17.5, Ks=16.1 and L(narrow)=10.0 mag at a signal-to-noise ratio of 10 in an integration time of 100 s. KASI has been also developing the MIRIS (Multi-purpose InfraRed Imaging System) after KASINICS project. MIRIS is the main payload of the STSAT-3 (Science and Technology Satellite 3) in Korea. MIRIS space observation camera (SOC) covers the observation wavelength from 0.9㎛ to 2.0㎛ with a wide field of view 3.67˚☓3.67˚. The PICNIC HgCdTe detector in a cold box is cooled down below 100K by a micro Stirling cooler of which cooling capacity is 220mW at 77K. MIRIS SOC adopts passive cooling technique to chill the telescope below 200 K by pointing to the deep space (3K). The cooling mechanism employs a radiator, a Winston cone baffle, a thermal shield, MLI (Multi Layer Insulation) of 30 layers, and GFRP (Glass Fiber Reinforced Plastic) pipe support in the system. Optomechanical analysis was made in order to estimate and compensate possible stresses from the thermal contraction of mounting parts at cryogenic temperatures. Finite Element Analysis (FEA) of mechanical structure was also conducted to ensure safety and stability in launching environments and in orbit. MIRIS SOC will mainly perform the Galactic plane survey with narrow band filters (Pa and Pa continuum) and CIB (Cosmic Infrared Background) observation with wide band filters (I and H) driven by a cryogenic stepping motor. 이 논문에서는 지상망원경용 KASINICS (Korea Astronomy and Space science Institute Near Infrared Camera System)와 과학기술위성 3호의 주 탑재체인 MIRIS (Multi-purpose InfraRed Imaging System)의 개발에 대한 연구 과정과 그 결과를 기술한다. 이 시스템들은 국내에서 처음으로 개발한 천문관측용 근적외선 기기들이다. KASINICS는 한국천문연구원의 적외선 관측기술 개발과 적외선 천문 관측의 목적으로 국내 보현산천문대 1.8m 망원경에 장착되기 위해 개발되었다. KASINICS의 관측 파장은 1-5㎛ 근적외선이며, Raytheon사의 512☓512 InSb 적외선 검출기를 사용하여 J, H, Ks, L 밴드 영역을 주로 관측한다. 그 검출기의 화각 (Field of View)은 3.3'☓3.3' 이며, 픽셀 해상도는 0.39" 이다. 이 시스템은 오프너 (Offner) 광학계를 사용한다. 저온으로 냉각되는 오프너 광학계는 구면인 주경과 부경의 배치를 통해서 광학망원경의 구조부로부터 오는 배경 열잡음을 부경이 효과적으로 차폐하는 cold stop 기능을 제공한다. 주, 부경을 포함한 대부분의 구조물은 상온에서 80K으로 냉각할 때 광학계의 열 수축을 일정하게 하기 위해서 동일한 알루미늄 재질로 제작되었다. 검출기의 영상을 읽는 전자제어장치 또한 시스템 운영을 위해서 새롭게 개발되었다. 현재, 시험관측 결과로부터 계산된 보현산천문대 1.8m 망원경에서의 관측 한계등급은 S/N=10이고 100초의 노출시간을 가정했을 때, J에서 17.6등급, H에서 17.5등급, Ks에서 16.1등급, L(협대역 필터)에서 10.0등급이다. 한국천문연구원에서는 또한 KASINICS 과제가 끝난 후에 바로 이어서 과학기술위성 3호의 주탑재체인 다목적적외선영상시스템 MIRIS를 개발해오고 있다. MIRIS의 우주관측카메라 (SOC, Space Observation Camera)는 0.9-2.0㎛ 관측 파장에서 3.67˚☓3.67˚ 화각을 가지고 있다. Cold box 안에 있는 PICNIC 256☓256 HgCdTe 검출기는 77K에서 220mW의 냉각용량을 가지는 소형 Stirling 냉동기에 의해 100K 이하로 냉각된다. MIRIS SOC는 고도 700km의 태양동기궤도에서 위성체의 자세제어에 의해 3K의 심 우주 (deep space)를 지속적으로 바라봄으로써 복사 냉각에 의해 망원경과 듀어가 약 200K 이하로 냉각된다. 이러한 passive cooling을 효과적으로 도와주기 위해서 MIRIS SOC는 방열판, 윈스톤 콘 배플, thermal-shield, 30층의 MLI (Multi Layer Insulation), GFRP (Glass Fiber Reinforced Plastic) 파이프 지지대 등을 탑재한다. 저온 광학계의 열 수축 스트레스와 발사 환경 조건을 보상해주기 위해 광기계부 해석 연구가 함께 수행되었다. 발사 환경의 안전과 파손 방지를 위해 기계구조부의 유한요소해석 또한 실시되었으며, 그러한 해석 결과를 바탕으로 기계구조부가 설계되고 제작되었다. MIRIS SOC는 Pa α 방출선을 이용해 우리 은하지도를 작성하고, I, H 밴드에서 적외선 우주 배경 복사 (Cosmic Infrared Background Radiation)를 관측할 예정이다. 이러한 필터들은 저온용 냉각 모터에 의해 구동하게 된다. MIRIS SOC는 passive cooling 시험과 위성 환경시험을 통과했으며, 그 시스템의 주요 요구조건을 만족시키는 것으로 실험을 통해 확인되었다.

상호텍스트성으로 본 『어린왕자』의 교육적 의미

육현수 중부대학교 2020 국내박사

본 연구는 상호텍스트성 동화 활동의 유아교육적 의미를 도출하기 위한 목적으로 수행되었다. 이를 위하여 선정된 동화는 생텍쥐베리가 쓴 『어린왕자』이다. 본 연구의 목적을 달성하기 위한 연구문제는 다음과 같다. 첫째, 텍스트로서의『어린왕자』에서 만난 것은 무엇인가? 둘째, 텍스트로서의『어린왕자』와의 만남에서 새롭게 알게 된 것은 무엇인가? 본 연구를 수행한 방법은 문학이론에서 현대적 개념으로 적용되고 있는 열린 텍스트 관점에서 진행되었다. 본 연구에서는 동화를 읽어간다는 의미보다 독자가 동화의 주인공과 만나는 것이다. 그리고 서로 이야기를 주고받는 방식으로 독자와 책의 만남을 친밀하게 지속하는 것에 중점을 두었다. 그러한 과정에서 독자는 새로운 삶의 세계에 대한 의미를 발견하고 그 발견된 것에 대해서 성찰하는 활동도 함께 병행되었다. 본 연구에서 나타난 결과는 다음과 같다. 첫째, 상호텍스트성으로『어린왕자』를 만난 결과는 다음과 같다, 1)어른과 어린왕자의 만남 이야기(1~4). 2)어린왕자가 자기별을 떠난 이야기(5~9). 3)어린왕자가 다른 별들을 여행하는 이야기(10~15). 4)어린왕자가 지구별을 여행하는 이야기(16~23). 5)어른과 어린왕자의 헤어짐 이야기(24~27) 둘째, 성호텍스트성으로 본『어린왕자』의 교육적 의미는 다음과 같다. 1) 우리가 살고 있는 세상은 사람마다 다르게 보일 수 있다는 것. 2)어른과 어린이가 살아가는 세상이 다르다는 것. 3)세상은 ‘보이는 세상’과 ‘안 보이는 세상’이 있다는 것. 4)어린이를 어른의 세계관으로 대하면 안 된다는 것. 5)어른과 어린이는 함께 성장하는 상호텍스트성 관계라는 것. 본 연구의 결론은 다음과 같다. 첫째, 동화를 상호텍스트성으로 활동하는 것은 매우 유용한 교육방법이다. 이러한 방법은 독자로 하여금 수많은 생각과 성찰이 이루어지게 하는 것으로 체험되었기 때문이다. 둘째, 상호텍스트성으로 본『어린왕자』는 유아교육자들에게 매우 유용한 교육적 의미를 제공해준다.『어린왕자』와의 만남에서 알게 된 유아교육적 의미가 매우 유용한 것으로 판단되었기 때문이다. 셋째, 유아교육기관에서 현직 교사를 대상으로 하는 상호텍스트성 동화활동 연수 방안을 심층적으로 고려할 필요가 있다. 넷째, 예비유아교사 교육과정에서 상호텍스트성 동화활동 교육과정을 적극적으로 운영할 필요가 있다. ABSTRACT The Educational Meaning of 「Little Prince」 in Intertextuality Hyunsoo Yuk Major in Early Childhood Education Department of Education Graduate School Joongbu University (Supervised by Professor Lee, Byung-Nae) The purpose of this study was to derive the meaning of early childhood education of intertextual fairy tales. The fairy tale chosen for this is The Little Prince, written by Saint-Exupéry. The research questions to achieve the purpose of this study are as follows. First, what did you encounter in The Little Prince as a text? Second, what did you derive about your encounter with「Little Prince」as a text? The method of this study was carried out from the perspective of open text applied as a modern concept in literary theory. In this study, the reader meets the main character of the fairy tale rather than reading it. The focus was on intimately keeping the reader and the book together by talking to each other. In the process, the reader also found out the meaning of the new world of life and reflected on the findings. The results of this study are as follows. First, the results of meeting in “Little Prince” as a text are as follows. 1)The story of an adult meeting with a little prince(1~4), 2)The story of a little prince leaving his star(5~9), 3)The story of a little prince traveling to other stars(10~15), 4)The story of a little prince traveling to Earth(16~23), 5)The separation of the adult and the little prince(24~27). Second, the meaning of early childhood education learned from the encounter with The Little Prince is as follows. 1)The world we live in can look different from person to person, 2)The world where adults and children live is different, 3)The world has a 'visible world' and 'invisible world', 4)Children should not be treated as an adult's worldview, 5)Adults and children are mutual textual relationships that grow together. The conclusions of this study are as follows. First, it is very useful teaching method to operate fairy tales intertextually. This is because it has been experienced to inspire the reader with many thoughts and reflections. Second, the intertextual "Little Prince" fairy tale activities provide very useful educational meaning for early childhood educators. It was because the meaning of early childhood education derived from the encounter with The Little Prince was very useful. Third, it is necessary to consider in-depth ways to develop intertextual fairy tales training for in-service teachers. Forth, it is necessary to actively operate the intertextual fairy tales activity curriculum in the preschool teacher curriculum.

Phonetic transfer during code-switching : evidence from velar plosives in Korean and English

Baldoria Wu, Yuk Ki Graduate School, Yonsei University 2024 국내석사

Code-switching is a bilingual phenomenon that requires speakers to be fluent in at least two languages. Naturally, this means that bilinguals have two or more language systems, but the level of interaction between the systems is often debated. From a phonetical point of view, the Revised Speech Learning Model (SLM-r) proposes that a new phonetic sound from the second language (L2) either merges with an existing category in the first language (L1) or a new category is created depending on how dissimilar the new sound is from the pre-existing L1 sounds (Flege & Bohn, 2021). In this light, different components in the phonetical framework vary in their interaction level across the languages. The present study looks at the effect of 1) Language Switching and 2) Language Context from a phonetical framework on the velar productions by Korean-English bilinguals to understand the interaction level between both languages. Most existing research on the impact of Language Switch seldom accounts for the spontaneity of bilingual switching, looks at three-way laryngeal languages, or focuses on F0 values. In light of this, the present study examines the effect of Language Context and Language Switch on the VOT and F0 values of velar stops by Korean-English bilinguals in an online, cued picture-naming experiment. A total of 36 bilinguals dominant in either English or Korean were tasked to name pictures in a Monolingual English Context, Monolingual Korean Context, and Bilingual Context. The stimuli were also produced as Switch and Non-switch tokens, with Switch tokens being produced in the opposite language of the preceding token. Results show that Language Switch and Language Context affect the VOT and F0 of the velar stops. However, not all five velars were affected by the presence of Switch and Context. When the results were separated according to language dominance, the Korean-dominant group was inclined to preserve the five distinct categories while the English preferred merging the velars. A possible explanation is the age of L2 acquisition, with earlier learners preferring category preservation over older learners, who preferred a velar merger. These results support the SLM-r on the underlying structure and the different levels of interaction between the languages in the bilinguals. L2 velars perceived as more similar to the L1 were merged, whereas a new group was created for L2 velars perceived as dissimilar from the L1.

Global safety signals of tramadol versus opioid analgesics : a signal detection study using WHO-VigiBase

Yuk, Jayeon Sungkyunkwan University 2025 국내석사

Das Prinzip Ironie bei Martion Walser

Yuk, Hyun Seung Westfalische Wilhelms-Universitat 2001 해외박사

Enumeration of genetic variants via a topological transformation-based nanobarcoding technique

Yuk, Jisoo Sungkyunkwan university 2019 국내석사

Non-invasive and patient-compliant medical treatments have been strongly on demand with an efficacious detection of circulating biomarkers in plasma. Out of them, miRNAs have been recently reported and highlighted favorably to be associated tightly with many diseases’ stage and prognosis. Cancers considered to be a serious threat to primates are known to be highly dominated by miRNA networks. Even though presently studied to be a potential medication in several cancer treatments, very few attempts have been made to diagnose it through in an effective manner. Among them, PCR-based methodology has been commonly used for the diagnosis of cancer. However, it is firmly ascribed that the PCR-based methodology in conventional sequencing techniques may probably restrict its operation to the miRNAs, due to its internal drawbacks including a difficulty of isolation, amplification, and even reading-out of such shorter genetic fragments. Here, we firstly report a new topological transformation-based nanobarcoding technique (TNT) using fluorescence-DNAs codes engaged with graphene oxide (GOx) for effectively discriminating miRNAs and even genetic variants in plasma without the use of PCRs. It was confirmed that this system can quantitatively detect up to 34 nM of targeted miRNA. In addition, the system was applied to miRNA mixtures extracted from cells to successfully detect targeted miRNAs. Furthermore, due to its three-dimensional triangle prism structure, multiple targeted genes could be detected at once. In confidence, its uses have been applied into positively discerning a tumor-derived EGFR mutant in plasma and a single variant of 0.785 % in targeted mutation gene was specifically detected. It was highly speculated that this new tool-kit may be a versatile method for a practical discrimination of several genetic deviations in media, which be an alternative to PCR terrains.

(The) impact of industrial diversification on the economic development of small open economies : the case of Hong Kong compared with Singapore

Fu, Yuk Fai Graduate School of International Studies, Korea Un 2020 국내석사

Swarm control of shape memory alloy based microrobots

Yu, Chak Yuk 서울대학교 대학원 2020 국내석사

The development of microrobots brings many great potential values in the microscale world such as to be implemented with small-scale applications for miniaturized operations in improving the existing technology of health care and providing more bioengineering solutions. In this study, a microrobot made of shape memory alloy (SMA) fabricated under focused ion beam (FIB) is introduced, trained to have a two-way shape memory effect (TWSME), which can be successfully driven by laser scanning exhibiting a crawling motion with reaching a maximum speed up to 150.1 µm s-1 with a short scan size (1 mm). A basic and simple swarm control methodology has been constructed successfully to manipulate multiple SMA microrobots to perform different actuation motions following the designated laser pathway. The direction of laser scanning can control the direction of the actuation of the robot, high maneuverability of controlling the microrobots can be realized by assigning the robots to reach the targeted destinations. It is proposed that the functionality can be broadened with implementing with the ability to transport and release substances or to exhibit a punching motion. 마이크로 로봇의 개발은 기존의 의료 기술을 개선하거나 생명 공학 연구에 새로운 방법을 제공하기 위한 마이크로 기술의 잠재 가치가 있다. 본 연구에서는 형상기억합금 소재의 마이크로 로봇 제작 공정과 제어 방법을 개발하였다. 형상은 집속이온빔 공정으로 제작하였으며, 구성 요소인 구동기가 양방향 형상기억효과를 가지도록 학습하였다. 자외선 레이저를 이용하여 구동하였으며 최대 150.1 µm s-1의 이동속도를 달성하였다. 기본적인 스웜 제어를 구현하기 위해서, 다수의 로봇이 서로 다른 경로로 이동하도록 제어시스템을 구축하였다. 로봇이 레이저 빔의 경로를 따라 움직이도록 제어하여 높은 기동성을 확보하였으며, 목표한 위치로 로봇을 이동시켰다. 마지막으로, 약물을 전달하거나 바늘을 이용한 찌르기와 같은 로봇의 활용 가능성을 제시하였다.