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HPV 관련성에 따른 구인두암에서의 positive/close 절제연의 의미
정유석(Yuh-Seog Jung) 대한두경부종양학회 2018 대한두경부 종양학회지 Vol.34 No.2
With the emerging knowledge about tumor biology specific for human papillomavirus (HPV)-related head and neck cancers, the classical understanding about the curative surgery in head and neck cancers are starting to progress, customized for their HPV-associations and ultimately specific for tumor biologic characteristics. The common rule for surgery should reflect the biologic characteristics of target tumors, but still, multi-institutional large-scale data could be scarce, due to the subjective feature of surgical treatment itself. However, the impact of HPV for margin determination is now being questioned by multiple groups, and typical example is European Cooperative Oncology Group (ECOG)-3311 study. Here, we review the impact of viral association for surgical decision and its biological background and implications.
Identification of occult tumors by whole-specimen mapping in solitary papillary thyroid carcinoma
Park, Seog Yun,Jung, Yuh-S,Ryu, Chang Hwan,Lee, Chang Yoon,Lee, You Jin,Lee, Eun Kyung,Kim, Seok-Ki,Kim, Tae Sung,Kim, Tae Hyun,Jang, Jeyun,Park, Daeyoon,Dong, Seung Myung,Kang, Jae-Goo,Lee, Jin Soo,R Society for Endocrinology 2015 Endocrine-related cancer Vol.22 No.4
<P>We undertook this study to estimate an accurate incidence and spread patterns of occult papillary thyroid carcinoma (PTC) in patients with a preoperative diagnosis of solitary PTC by using whole-specimen mapping of all specimens after a total thyroidectomy. Enrolled prospectively in this whole-thyroid mapping study are 82 consecutive patients who underwent a total thyroidectomy under a preoperative diagnosis of solitary PTC. All thyroidectomy specimens were serially sectioned in 2 mm thickness and whole-thyroid mapping was carried out for additional foci of occult PTC. The frequencies of occult lesions detected in the whole and contralateral lobe were determined, and clinicopathologic factors associated with multifocality were assessed. Whole-thyroid mapping revealed 66 occult PTC lesions missed by preoperative ultrasound in 37 (45.1%) of the 82 patients. The great majority (92.5%) of the occult PTC was smaller than 3 mm in size and 25 patients (30.5%) had contralateral lesions. We found that the male sex was an independent predictor of multifocality (odds ratio (OR), 3.00; 95% CI, 1.11–8.14), adjusting for preoperative findings. Analysis with pathologic parameters showed that the male sex (OR, 5.03; 95% CI, 1.68–15.08) and extrathyroidal extensions (OR, 3.03; 95% CI, 1.03–8.95) were associated with multifocal PTC. However, none of the clinicopathologic factors evaluated predicted contralateral PTC. Our study demonstrates the diagnostic limitations of ultrasound for the detection of multifocal PTC and the need to consider the possibility of occult lesions in the management of solitary PTC, especially in male patients.</P>
여상화(Sang-Hwa Yuh),백영태(Yeong-Tae Baek),채흥석(Heung-Seog Chae) 한국컴퓨터정보학회 2011 한국컴퓨터정보학회 학술발표논문집 Vol.19 No.1
본 논문에서는 스마트폰과 같은 모바일 단말기 자체에서 동작하는 경량화된 영한 하이브리드 모바일 번역 엔진을 설계 및 구현하였다. 번역 엔진은 자연스러운 번역과 높은 번역 품질을 위해 번역 메모리(Translation Memory)와 규칙기반의 번역 엔진으로 이중화를 하였다. PC에 비해 하드웨어 제약이 심한 스마트폰 자체에서 구동이 원활하도록 주메모리의 사용을 줄이고 분석 시간 단축을 위하여 핵심 번역 엔진을 포함한 번역 지식 DB가 외장메모리에서 구동되도록 하였다. 실험결과 번역 품질은 BLEU와 NIST 평가치를 기준으로 서버 기반의 구글번역기 대비 70.0%로 사용자의 의미전달이 가능한 실용적인 수준으로 평가되었다.
Operating a National Hotline in Korea During the COVID-19 Pandemic
Song Rok,Choi Yuh Seog,Ko Jae Young 질병관리본부 2020 Osong Public Health and Research Persptectives Vol.11 No.6
The importance of effective communication cannot be overestimated during a pandemic. The Korea Disease Control and Prevention Agency national 1339 hotline has been in operation since the Middle East respiratory syndrome coronavirus outbreak in 2016. The hotline is open 24 hours a day, 7 days a week, 365 days a year, and provides accurate, reliable information based upon the Korea Disease Control and Prevention Agency guidelines in response to queries. During the coronavirus disease 2019 (COVID-19) pandemic, the 1339 hotline received callers’ questions about symptoms and the implications of their actions regarding the epidemic. Through the 1339 hotline, callers received the up-to-date information that enabled them to protect themselves as well as others from COVID-19. This public service may have influenced on reduced risk of virus transmission in Korea.
A Case of Composite (Mixed) denocarcinoma-Small Cell Carcinoma of the Stomach
Kim, Nam Don,Park, Yeon Hee,Ki, Seung Seog,Park, Yong Jin,Kim, Heoyng Joon,Ryoo, Baek-Yeol,Kim, Heung Tae,Chung, Jin-Haeng,Yuh, Young Jin 인제대학교 백병원 2003 仁濟醫學 Vol.24 No.1
A composite (mixed) tumor is defined as a glandular-endocrine cell carcinomas characterized by an intricate admixture of both elements in the same lesion. The histogenesis of this tumor is not clear but is considered to be multidirectional differentiation from pluripotential stem cells. The clinical findings are local symptoms due to mass and systemic symptoms due to paraneoplastic syndrome. The prognosis is considered to be very poor because of a high incidence of vasculo-lymphatic invasion and markedly deep infiltration of small cell carcinoma (SCC) of this composite tumor. Treatment has not been established clearly yet, but treatment with regimens specific for SCC of the lung may be used because the biologic and clinical characteristics of gastric SCC are similar to those of SCC of the lung. We encountered a 70-year-old man with pain to the back and both elbows for 20 days on July 22, 2002. Esophagogastroduodenoscopic biopsy revealed a superficially well differentiated adenocarcinoma and a deeply located. poorly differentiated SCC in the same lesion of the stomach, along with multiple bony metastases. We treated the patient with a chemotherapeutic regimen (etoposide and carboplatin) and palliative radiotherapy. The patient complained of sustained abdominal pain and poor oral intake and he died about 5 months later.
Estimated incidence of juvenile-onset recurrent respiratory papillomatosis in Korea
Jin-Kyoung Oh,Hwa Young Choi,Minji Han1,Yuh-Seog Jung,Sang Joon Lee,Moran Ki 한국역학회 2021 Epidemiology and Health Vol.43 No.-
OBJECTIVES: Recurrent respiratory papillomatosis (RRP) is caused by human papillomavirus (HPV) types 6 and 11 and is potentially preventable through vaccination. This study estimated the incidence of juvenile-onset RRP before the implementation of the national HPV vaccination program in Korea. METHODS: We conducted a cohort study using claims data provided by a mandatory insurance program to estimate the incidence of RRP and associated healthcare use. Patients with juvenile RRP were defined as those aged ≤12 years with ≥2 admissions or ≥2 outpatient visits during which they received the International Classification of Diseases, 10th revision code for benign neoplasms of the larynx (D14.1). RESULTS: During 2002-2014, 123 children (74 boys and 49 girls) were diagnosed with RRP. The patients had a mean of 6.5 person-years of follow-up. The incidence was estimated at 0.30/100,000 person-years. The median age at diagnosis was 4.0 years (mean, 4.3). Thirty-six (29.3%) patients underwent surgery, including 23 patients (18.7%) who underwent 2 or more surgical procedures. Severe disease, measured by more frequent surgical procedures and shorter time intervals between consecutive operations, was associated with a younger age at diagnosis. CONCLUSIONS: The estimated incidence of juvenile-onset RRP in Korea was similar to that reported in other countries. The RRP burden should continue to be monitored using National Health Insurance Service claims data.