Protective Effect of All-Trans Retinoic Acid in Cisplatin-Induced Testicular Damage in Rats

Cem Yucel,Fatma Demet Arslan,Sumeyye Ekmekci,Volkan Ulker,Erdem Kisa,Elcin Erdogan Yucel,Murat Ucar,Yusuf Ozlem Ilbey,Orcun Celik,Banu Isbilen Basok,Zafer Kozacioglu 대한남성과학회 2019 The World Journal of Men's Health Vol.37 No.2

Purpose: To investigate the effects of all-trans retinoic acid (ATRA) in cisplatin (CP)-induced testicular damage in rats. Materials and Methods: Twenty-eight male Wistar rats were divided into four groups: Control, ATRA alone, ATRA+CP, and CP alone. Body weight, testicular weight, sperm count, sperm motility, percentage of abnormal sperm, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) in testicular tissue, and testicular histopathology were compared among groups. Results: The sperm count and motility significantly decreased and the percentage of abnormal sperm significantly increased in the CP group compared to the control and ATRA groups. CP+ATRA administration significantly increased the sperm count and motility, but reduced the abnormal sperm count. CP administration significantly increased TOS and OSI compared to the control group and the other groups. Administering CP+ATRA significantly decreased TOS and the OSI in testicular tissue and reduced spermatogenesis, but increased the Johnsen score. Conclusions: The destructive effects of CP treatment on testicular tissue and spermatogenesis were reduced by administering ATRA.

Effect of Cr and Zr on the Grain Structure of Extruded EN AW 6082 Alloy

Yucel Birol 대한금속·재료학회 2014 METALS AND MATERIALS International Vol.20 No.4

The effects of Cr and Zr addition on the coarse grain surface layer in EN AW 6082 tube extrusions wereinvestigated. The decoration of the tube surfaces and the weld seams with coarse recrystallized grainsreflects the strain as well as the temperature gradients that predominate across the section of the tubesduring extrusion. The recrystallization resistance provided by Mn does not suffice to avoid the coarse surfacegrains. With structural features that are almost identical to those of the base 6082 alloy, the 6082alloy with 0.06 wt% Zr also fails to offer any improvement. The coarse grain surface layer is much thinnerand recrystallization is entirely avoided across the weld seams upon the addition of 0.15 wt% Cr. Thesuperior recrystallization resistance of the revised alloy is attributed to the increase in the population of theCr-rich Al(Cr,Mn,Fe)Si as well as (Al, Si)3Zr dispersoid particles. It is reasonable to conclude that the coadditionof Zr and Cr has a favourable impact on the resistance to recrystallization of EN AW 6082 alloy.

Determining the Factors that Affect Breast Cancer and Self Breast Examination Beliefs of Turkish Nurses in Academia

Yucel, Sebnem Cinar,Orgun, Fatma,Tokem, Yasemin,Avdal, Elif Unsal,Demir, Muzeyyen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3

Purpose: To define factors that affect the performance status of BSE and confidence of student nurses. Materials and Methods: This descriptive study was conducted in the academic year 2010-2011 in a nursing faculty in $\dot{I}$zmir, Turkey. "Informative data form" and "Champion's Revised Health Belief Model Scale (CHBMS)" were used as data collection forms. Results: The mean age of the participant nurses was $21.0{\pm}1.49$. The mean CHMS scores of the student nurses were as follows: perceived susceptibility regarding breast cancer, $7.78{\pm}2.46$; perceived seriousness regarding breast cancer, $22.4{\pm}5.43$; perceived benefit regarding BSE application, $20.5{\pm}4.45$; perceived barriers regarding BSE application, $23.8{\pm}7.13$; perceived confidence regarding BSE application, $36.3{\pm}7.78$; the mean score of health motivation sub-scale, $25.7{\pm}4.59$; and mean of the total score of the scale, $36.5{\pm}15.01$. Conclusions: The outcomes obtained in this study indicated the importance of better education to student nurses, who have a key role in teaching preventive health behaviour including BSE to society and other university students as colleagues.

Survival Analysis and Prognostic Factors for Neuroendocrine Tumors in Turkey

Yucel, Birsen,Babacan, Nalan Akgul,Kacan, Turgut,Eren, Ayfer Ay,Eren, Mehmet Fuat,Bahar, Seher,Celasun, Mustafa Gurol,Seker, Mehmet Metin,Hasbek, Zekiye Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Background: This study aimed to determine the demographical distribution, survival and prognostic factors for neuroendocrine tumors monitored in our clinic. Materials and Methods: Data for 52 patients who were admitted to Cumhuriyet University Medical Faculty Training Research and Practice Hospital Oncology Center between 2006 and 2012 and were diagnosed and treated for neuroendocrine tumors were investigated. Results: Of the total, 30 (58%) were females and 22 (42%) were males. The localization of the disease was gastroenteropancreatic in 29 (56%) patients and other sites in 23 (44%). The most frequently involved organ in the gastroenteropancreatic system was the stomach (n=10, 19%) and the most frequently involved organ in other regions was the lungs (n=10, 19%). No correlation was found between immunohistochemical staining for proteins such as chromogranin A, synaptophysin, and NSE and the grade of the tumor. The patients were followed-up at a median of 24 months (1-90 months). The three-year overall survival rate was 71%: 100% in stage I, 88% in stage II, 80% in stage III, and 40% in stage IV. The three-year survival rate was 78% in tumors localized in the gastroenteropancreatic region, and 54% in tumors localized in other organs. In the univariate analysis, gender, age, performance status of the patients, grade, localization, surgical treatment, and neutrophil/lymphocyte ratio (${\leq}5$ versus >5) affected the prognosis of the patients. Conclusions: Most of the tumors were localized in the gastroenteropancreatic region, and the three-year survival rate in tumors localized in this region was better than the tumors localized in other sites. Surgical treatment was a positive independent prognostic factor, whereas Grade 3 and a neutrophil/lymphocyte ratio of >5 were negative independent prognostic factors.

Measurement of Photo-Neutron Dose from an 18-MV Medical Linac Using a Foil Activation Method in View of Radiation Protection of Patients

Yucel, Haluk,Cobanbas, Ibrahim,Kolbasi, Asuman,Yuksel, Alptug Ozer,Kaya, Vildan Korean Nuclear Society 2016 Nuclear Engineering and Technology Vol.48 No.2

High-energy linear accelerators are increasingly used in the medical field. However, the unwanted photo-neutrons can also be contributed to the dose delivered to the patients during their treatments. In this study, neutron fluxes were measured in a solid water phantom placed at the isocenter 1-m distance from the head of an18-MV linac using the foil activation method. The produced activities were measured with a calibrated well-type Ge detector. From the measured fluxes, the total neutron fluence was found to be $(1.17{\pm}0.06){\times}10^7n/cm^2$ per Gy at the phantom surface in a $20{\times}20cm^2$ X-ray field size. The maximum photo-neutron dose was measured to be $0.67{\pm}0.04$ mSv/Gy at $d_{max}=5cm$ depth in the phantom at isocenter. The present results are compared with those obtained for different field sizes of $10{\times}10cm^2$, $15{\times}15cm^2$, and $20{\times}20cm^2$ from 10-, 15-, and 18-MV linacs. Additionally, ambient neutron dose equivalents were determined at different locations in the room and they were found to be negligibly low. The results indicate that the photo-neutron dose at the patient position is not a negligible fraction of the therapeutic photon dose. Thus, there is a need for reduction of the contaminated neutron dose by taking some additional measures, for instance, neutron absorbing-protective materials might be used as aprons during the treatment.

Frost resistance of layered concrete systems incorporating ECC as overlay materials

Yucel, Hasan E. Techno-Press 2021 Advances in concrete construction Vol.12 No.3

Concrete structures are subjected to severe durability issues and freeze-thaw action is one of these detrimental issues. In this paper, the behavior of high-volume Class-F fly ash (FA) and slag (SL) incorporated Engineered Cementitious Composites (ECC) as overlay materials was assessed when they were under cyclic freezing and thawing effect. Silica fume concrete (SFC) was also tested as a control mixture which is generally used for overlaying purposes. Layered ECC/substrate concrete (SC) and SFC/SC beam specimens were produced and subjected to 300 freeze-thaw cycles in accordance with ASTM C666, Procedure A. Laboratory tests performed using the layered specimens were based on the determination changes of (i) residual mechanical properties (flexural strength -mid-span beam deflection curves), (ii) ultrasonic pulse velocity (UPV), (iii) mass loss, (iv) relative dynamic modulus of elasticity (RDME) and (v) durability factor (DF). Test results show that all layered specimens produced with different ECC mixtures safely survived 300 freeze-thaw cycles without any disturbance between the ECC overlay and SC interface. On the other hand, one out of six tested SFC/SC layered specimens survived 300 freeze-thaw cycles and final failure for five failed specimens took place from the interfacial planes. Significantly better frost resistance of overlaid systems produced with ECCs than those with SFC was also verified with all of the tests proposed. Between different ECC mixtures, those produced with slag performed better than that those with Class-F fly ash.

Friction Stir Welding of Twin-Roll Cast EN AW 3003 Plates

Yucel Birol,Sefika Kasman 대한금속·재료학회 2013 METALS AND MATERIALS International Vol.19 No.6

Twin-roll cast EN AW 3003 plates were butt-welded with friction stir welding and their structural features were identified. Sound welds were obtained in twin-roll cast EN AW 3003 plates at tool rotation speeds higher than 500 rpm. The ultimate tensile strength of the welded plates was 134 ± 3 MPa, comparable to the ultimate tensile strength of the original plate, at 146 MPa. The stirring action of the pin fractured the interdendritic network and coarse eutectic cells, replacing the dendritic features of the base plate with a uniform dispersion of very fine intermetallic particles across the stir zone. The thermal and mechanical cycles introduced during FSW relaxed the supersaturation of the cast plate, leading to the precipitation of intermetallic particles. This precipitation activity produced a particle population gradient that peaks inside the stir zone and dictates the etching response across the plate section. The material in direct contact with the rotating pin is severely deformed and is exposed to frictional heating and inevitably undergoes dynamic recrystallization. The very fine grain structure thus obtained suffers abnormal grain growth when annealed at high temperatures due to the effective pinning of the grain boundaries by the fine particles.

Lack of Impact of Age on Acute Side Effects and Tolerance of Curative Radiation Therapy

Yucel, Birsen,Okur, Yillar,Akkas, Ebru Atasever,Eren, Mehmet Fuat Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

Aim: The aim of this study was to determine the impact of age on the occurrence, severity, and timing of acute side effects related to radiotherapy. Materials and Methods: We analysed the data of 423 patients. Results: Of the patients, 295 (70%) were under the age of 65 (group 1) and 128 (30%) were over the age of 65 (group 2). The frequencies of radiotherapy-induced side effects were 89% in group 1 and 87% in group 2 (p=0.286). The mean times to occurrence were $2.5{\pm}0.1$ weeks in group 1 and $2.2{\pm}0.1$ weeks in group 2 (p=0.013). Treatment was ended in 2% of patients in group 1 and 6% of those in group 2 (p=0.062). Treatment interruption was identified in 18% of patients in group 1 and 23% in group 2 (p=0.142). Changes in performance status were greater in older patients (p=0.013). There were no significant differences according to the frequency or severity of side effects, except skin and genitourinary complications, between the groups. Conclusions: Early normal tissue reactions were not higher in older versus younger patients, though there was a tendency towards an earlier appearance.

On Generalized FI-extending Modules

Yucel, Canan Celep Department of Mathematics 2020 Kyungpook mathematical journal Vol.60 No.1

A module M is called FI-extending if every fully invariant submodule of M is essential in a direct summand of M. In this work, we define a module M to be generalized FI-extending (GFI-extending) if for any fully invariant submodule N of M, there exists a direct summand D of M such that N ≤ D and that D/N is singular. The classes of FI-extending modules and singular modules are properly contained in the class of GFI-extending modules. We first develop basic properties of this newly defined class of modules in the general module setting. Then, the GFI-extending property is shown to carry over to matrix rings. Finally, we show that the class of GFI-extending modules is closed under direct sums but not under direct summands. However, it is proved that direct summands are GFI-extending under certain restrictions.

In Vitro Antimicrobial Effect of Satureja wiedemanniana Against Bacillus Species Isolated from Raw Meat Samples

Nihal Yucel,Belma Aslim,Hakan Özdoğan 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.4

the presence of Bacillus species. Among the meat samples analyzed, the predominant species isolated was Bacillus circulans; other Bacillus species were identified as Bacillus firmus, Bacillus lentus, Bacillus megaterium, Bacillus licheniformis, Bacillus mycoides, Bacillus sphaericus, and Bacillus cereus. Minced meat samples were more contaminated with Bacillus species than sliced beef sample. From these samples, 242 Bacillus species isolates were obtained, which were investigated for proteolytic and lipolytic activity, associated with meat spoilage. Interestingly, some Bacillus strains produced the highest values of proteolytic/lipolytic activities. Nineteen Bacillus strains were selected among the 242 isolates according to their proteolytic/lipolytic activity with a clear zone diameter of ≥6mm. The essential oil of Satureja wiedemanniana (Lalem) Velen was also tested against these 19 Bacillus species that had proteolytic and lipolytic activity. The essential oil yield obtained from the aerial parts of the plant was 0.35% (vol/wt). The inhibition zones of the essential oil obtained against all the Bacillus species were in the range of 5.0–12.0mm. The oil showed high antimicrobial activities against B. licheniformis M 6(26), M 11(16), and M 12(1) strains. B. licheniformis 12(1) showed high lipolytic activity (18.0mm). Also, B. licheniformis M 6(26) and M 11(16) showed high proteolytic activity (16.0 and 14.0mm). These results may suggest that an essential oil of S. wiedemanniana can be used as a natural preservative in meat against spoilage bacteria.