Alveolar bone thickness around maxillary central incisors of different inclination assessed with cone-beam computed tomography

Yu-lou Tian,Fang Liu,Hong-jing Sun,Pin Lv,Yu-ming Cao,Mo Yu,Yang Yue 대한치과교정학회 2015 대한치과교정학회지 Vol.45 No.5

Objective: To assess the labial and lingual alveolar bone thickness in adults with maxillary central incisors of different inclination by cone-beam computed tomography (CBCT). Methods: Ninety maxillary central incisors from 45 patients were divided into three groups based on the maxillary central incisors to palatal plane angle; lingual-inclined, normal, and labial-inclined. Reformatted CBCT images were used to measure the labial and lingual alveolar bone thickness (ABT) at intervals corresponding to every 1/10 of the root length. The sum of labial ABT and lingual ABT at the level of the root apex was used to calculate the total ABT (TABT). The number of teeth exhibiting alveolar fenestration and dehiscence in each group was also tallied. One-way analysis of variance and Tukey’s honestly significant difference test were applied for statistical analysis. Results: The labial ABT and TABT values at the root apex in the lingual-inclined group were significantly lower than in the other groups (p < 0.05). Lingual and labial ABT values were very low at the cervical level in the lingual-inclined and normal groups. There was a higher prevalence of alveolar fenestration in the lingual-inclined group. Conclusions: Lingual-inclined maxillary central incisors have less bone support at the level of the root apex and a greater frequency of alveolar bone defects than normal maxillary central incisors. The bone plate at the marginal level is also very thin.

Cytoprotective Effect of Taurine against Hydrogen Peroxide-Induced Oxidative Stress in UMR-106 Cells through the Wnt/β-Catenin Signaling Pathway

Lou, Jing,Han, Donghe,Yu, Huihui,Yu, Guang,Jin, Meihua,Kim, Sung-Jin The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.6

Osteoporosis development is closely associated with oxidative stress and reactive oxygen species (ROS). Taurine has potential antioxidant effects, but its role in osteoblasts is not clearly understood. The aim of this study was to determine the protective effects and mechanisms of actions of taurine on hydrogen peroxide ($H_2O_2$)-induced oxidative stress in osteoblast cells. UMR-106 cells were treated with taurine prior to $H_2O_2$ exposure. After treatment, cell viability, apoptosis, intracellular ROS production, malondialdehyde content, and alkaline phosphate (ALP) activity were measured. We also investigated the protein levels of ${\beta}-catenin$, ERK, CHOP and NF-E2-related factor 2 (Nrf2) along with the mRNA levels of Nrf2 downstream antioxidants. The results showed that pretreatment of taurine could reverse the inhibition of cell viability and suppress the induced apoptosis in a dose-dependent manner: taurine significantly reduced $H_2O_2$-induced oxidative damage and expression of CHOP, while it induced protein expression of Nrf2 and ${\beta}-catenin$ and activated ERK phosphorylation. DKK1, a Wnt/${\beta}-catenin$ signaling inhibitor, significantly suppressed the taurine-induced Nrf2 signaling pathway and increased CHOP. Activation of ERK signaling mediated by taurine in the presence of $H_2O_2$ was significantly inhibited by DKK1. These data demonstrated that taurine protects osteoblast cells against oxidative damage via Wnt/${\beta}-catenin$-mediated activation of the ERK signaling pathway.

Cytoprotective Effect of Taurine against Hydrogen Peroxide- Induced Oxidative Stress in UMR-106 Cells through the Wnt/β- Catenin Signaling Pathway

( Jing Lou ),( Donghe Han ),( Huihui Yu ),( Guang Yu ),( Meihua Jin ),( Sung-jin Kim ) 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.6

Osteoporosis development is closely associated with oxidative stress and reactive oxygen species (ROS). Taurine has potential antioxidant effects, but its role in osteoblasts is not clearly understood. The aim of this study was to determine the protective effects and mechanisms of actions of taurine on hydrogen peroxide (H₂O₂)-induced oxidative stress in osteoblast cells. UMR-106 cells were treated with taurine prior to H₂O₂ exposure. After treatment, cell viability, apoptosis, intracellular ROS production, malondialdehyde content, and alkaline phosphate (ALP) activity were measured. We also investigated the protein levels of β-catenin, ERK, CHOP and NF-E2-related factor 2 (Nrf2) along with the mRNA levels of Nrf2 downstream antioxidants. The results showed that pretreatment of taurine could reverse the inhibition of cell viability and suppress the induced apoptosis in a dose-dependent manner: taurine significantly reduced H₂O₂-induced oxidative damage and expression of CHOP, while it induced protein expression of Nrf2 and β-catenin and activated ERK phosphorylation. DKK1, a Wnt/β-catenin signaling inhibitor, significantly suppressed the taurine-induced Nrf2 signaling pathway and increased CHOP. Activation of ERK signaling mediated by taurine in the presence of H₂O₂ was significantly inhibited by DKK1. These data demonstrated that taurine protects osteoblast cells against oxidative damage via Wnt/β-catenin-mediated activation of the ERK signaling pathway.

Impacts of WRF Model Domain Size on Meiyu Rainfall Forecasts over Zhejiang, China

Zhenshou Yu,Mengwen Wu,Jinzhong Min,Yu Yan,Xiaofen Lou 한국기상학회 2022 Asia-Pacific Journal of Atmospheric Sciences Vol.58 No.2

We explore impacts of model domain size on rainfall forecasts over Zhejiang Province during the Meiyu season in this paper. The existing modeling system is based on the Weather Research and Forecasting (WRF), which is referred to as the Zhejiang WRF with Advanced Data Assimilation System(ADAS) Real-time Modeling System (ZJWARMS). First, we identify the regions with large uncertainties of model forecasts using correlation analysis of different reanalysis datasets. Five key regions affecting precipitation in Zhejiang are identified by calculating the correlation-coefficients between precipitation in Zhejiang and largescale atmospheric factors. A new WRF model domain, called ZJdomain, is then chosen to cover the key regions and to avoid the regions with large uncertainties. To evaluate the differences of precipitation forecasts in each precipitation category between using the new domain, ZJdomain, and using the current operational model domain, ZJWARMS, two sets of experiments are conducted, including two case studies and a batch test based on daily 72-h forecasts. The results suggest that the ZJdomain can better simulate the key weather systems and their associated precipitation in Zhejiang. Quantitative tests of different-category precipitation also show that the equivalent threat score (ETS) increases significantly, and the frequency of missed (FOM) and the false alarm ratio (FAR) decrease with varying degrees. In the batch test, the ETSs of the torrential rain in forecasts with the lead times of 24–48 h and 48–72 h increase by 100.3% and 62.1%, respectively. Compared with the Shanghai Meteorological Service WRF ADAS Real-time Modeling System version 2.0 (SMSWARMS), it is found that the unsuitable WRF model domain is one of the main reasons that the precipitation forecast error of ZJWARMS is always larger than that of SMSWARMS. This study demonstrates that the selection of a suitable model domain is a key to improve the forecast of regional operational numerical weather prediction systems.

중국 뚜도우의 조형이 반영된 현대 패션 디자인 연구

노사우 ( Lou Si Yu ),최유진 ( Choi Yoo Jin ),김정숙 ( Kim Jung Sook ) 한국기초조형학회 2017 기초조형학연구 Vol.18 No.2

본 연구는 중국의 전통적인 여성 속옷인 뚜도우를 주제로 하여 뚜도우의 기원과 발전, 디자인 특성, 미적 특성 탐구에서 시작했다. 2007년부터 2016년까지의 패션 컬렉션에서 발표된 의상 중에서 뚜도우의 조형이 활용된 것으로 분석되는 180점의 패션 사진을 수집해 디자인의 빈도와 특성, 그리고 미적특성을 분석했다. 분석한 결과, 크게 수영복 스타일, 드레스 스타일, 란제리 스타일의 3가지 스타일로 활용되었다. 3 가지 스타일에 어떠한 형태의 뚜도우가 활용 되었는지를 고찰하기 위해 뚜도우 디자인에 따라 방형, 제형, 삼각형, 마름모형의 4가지로 분류해 고찰했다. 수영복 스타일의 경우는 제형이 가장 높은 비중을 차지했으며, 다음으로는 삼각형, 방형, 마름모형의 순서로 비중이 높게 나타났다. 드레스 스타일의 경우는 방형, 제형, 삼각형, 마름모형의 순서로 나타났다. 제형과 방형이 전체의 70%이상을 차지했다. 마지막으로 란제리 스타일은 방형, 제형(삼각형, 마름모형의 순서로 비중이 높았으며, 방형이 50%에 미치지는 않지만 높은 비중을 차지했다. 최종적으로 본 연구에서는 중국 전통 뚜도우의 관능미, 장식미, 전통미가 현대 패션에서는 어떻게 나타났는지를 살펴보았다. 뚜도우는 평면적으로 구성된 의상이지만 어깨와 가슴, 허리 부분의 절개를 통한 노출을 통해서 여성의 관능적인 아름다움을 표현하는데 기여했다. 이 뿐만 아니라 뚜도우의 절개된 라인과 소재, 문양 등이 장식적인 요소로 활용되어 현대 패션에서도 장식미를 부각시켰다. 마지막으로 전통적인 소재나 컬러가 활용된 전통미의 경우는, 중국 전통적인 양식에 머무르기 보다는 현대적으로 재해석된 모던한 디자인으로 도입되었다. This study started to clarify origin, development, design characteristics, aesthetic characteristic of dudou, chinese traditional women`s underwear. This article analyzed frequency, characteristics and aesthetic characteristics of 180 fashion photo used form of `dudou` from 2007 to 2016 in fashion collections. The result of analyse, contemporary fashion applied `dudou` shape categorized three type, swim suit type, dress type, lingerie type. To clarify which form used to the former three type, this article categorized top design to 4 shape, rectangular shape, trapezoidal shape, triangular shape, diamond shape. In case of swim suit style, trapezoidal shape was highly percentaged and triangular, rectangular, diamond shape is next. In case of dress style, rectangular, trapezoidal, triangular, diamond shape were arranged according to percentage, particularly trapezoidal and rectangular shape was over 70% percentaged. Last, in case of lingerie style, rectangular, trapezoidal( triangular, diamond shape were arranged according to frequency. Rectangular shape was percentaged almost 50%. And then this study examined the aesthetic characteristics of `dudou` (1.erotic, 2.decorative, 3.traditional) which appeared in contemporary fashion design. Despite `dudou` was flat-patterned, expose of body through cutting in shoulder, chest, waist part expressed erotic beauty. In addition, the cutting line of dudou, material, textile design applied to decorative element, added decorative beauty in contemporary fashion collection. And last, traditional beauty used chinese traditional cloth and color represented more modern style fashion design in contemporary fashion.

Family History of Cancer and Head and Neck Cancer Risk in a Chinese Population

Huang, Yu-Hui Jenny,Lee, Yuan-Chin Amy,Li, Qian,Chen, Chien-Jen,Hsu, Wan-Lun,Lou, Pen-Jen,Zhu, Cairong,Pan, Jian,Shen, Hongbing,Ma, Hongxia,Cai, Lin,He, Baochang,Wang, Yu,Zhou, Xiaoyan,Ji, Qinghai,Zho Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17

Background: The aim of this study was to investigate whether family history of cancer is associated with head and neck cancer risk in a Chinese population. Materials and Methods: This case-control study included 921 cases and 806 controls. Recruitment was from December 2010 to January 2015 in eight centers in East Asia. Controls were matched to cases with reference to sex, 5-year age group, ethnicity, and residence area at each of the centers. Results: We observed an increased risk of head and neck cancer due to first degree family history of head and neck cancer, but after adjustment for tobacco smoking, alcohol drinking and betel quid chewing the association was no longer apparent. The adjusted OR were 1.10 (95% CI=0.80-1.50) for family history of tobacco-related cancer and 0.96 (95%CI=0.75-1.24) for family history of any cancer with adjustment for tobacco, betel quid and alcohol habits. The ORs for having a first-degree relative with HNC were higher in all tobacco/alcohol subgroups. Conclusions: We did not observe a strong association between family history of head and neck cancer and head and neck cancer risk after taking into account lifestyle factors. Our study suggests that an increased risk due to family history of head and neck cancer may be due to shared risk factors. Further studies may be needed to assess the lifestyle factors of the relatives.

PTEN mutation predicts unfavorable fertility preserving treatment outcome in the young patients with endometrioid endometrial cancer and atypical hyperplasia

Yu Xue,Youting Dong,Yaochen Lou,Qiaoying Lv,Weiwei Shan,Chao Wang,Xiaojun Chen 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.4

Objective: This study aimed to investigate the impact of molecular classification and PTEN, KRAS and PIK3CA gene mutation on the outcome of fertility-preserving treatment in the patients with endometrioid endometrial cancer (EEC) and endometrial atypical hyperplasia (EAH). Methods: This is a single-center retrospective study. A total of 135 patients with EEC and EAH receiving fertility-preserving treatment and molecular classification were reviewed. The distribution of the four types of molecular classification was described. The impact of non-specific molecular profile (NSMP), mismatch repair-deficiency (MMRd), and PTEN, KRAS and PIK3CA gene mutation on the outcome of fertility-preserving treatment was analyzed. Results: Of the patients analyzed, 86.7% (117/136) were classified as having NSMP; 14 (10.4%), MMRd; 1 (0.7%), POLEmut EAH; and 3 (2.2%), p53abn EEC. The patients having NSMP and MMRd achieved similar 16-, 32-, and 48-week complete response rates. The patients harboring tier I and tier II PTEN mutations (PTENmut-Clin) achieved lower cumulative 32-week CR rates than those with PTEN-others (without PTENmut-Clin) (22/47, 46.8% vs. 50/74, 67.6%; p=0.023; odds ratio=0.422; 95% confidence interval [CI]=0.199–0.896). Insulin-resistance (hazard ratio [HR]=0.435; 95% CI=0.269–0.702; p=0.001) and PTENmut-Clin (HR=0.535; 95% CI=0.324–0.885; p=0.015) were independent negative predictors for lower 32-week CR rates. Conclusion: PTENmut-Clin is an independent risk factor for unfavorable fertility-preserving treatment outcomes in the patients with EEC and EAH. The patients with MMRd receiving fertility-preserving treatment achieved outcomes similar to those of the patients with NSMP. The molecular profiles might guide fertility-preserving treatment in the prognosis and clinical decisions.

The optical and mechanical properties of Al doped zinc oxide thin film fabricated by high power impulse magnetron sputtering

Yu-Ci HONG,Jyh-Wei LEE,Bih-Show LOU 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8

Carbon coated porous nickel phosphides nanoplates for highly efficient oxygen evolution reaction

Yu, Xin-Yao,Feng, Yi,Guan, Buyuan,(David) Lou, Xiong Wen,Paik, Ungyu The Royal Society of Chemistry 2016 Energy & environmental science Vol.9 No.4

<P>Electrochemical splitting of water provides an attractive way to produce hydrogen fuel. Unfortunately, the efficient and large-scale H-2 production is still hindered by the sluggish kinetics of the oxygen evolution reaction (OER) at the anode side of a water electrolyzer. Starting from metal-organic frameworks (MOFs), we demonstrate a template-engaged strategy to transformNi-Ni Prussian blue analogue (PBA) nanoplates into porous carbon coated nickel phosphides nanoplates with mixed phases of Ni5P4 and Ni2P. For comparison, NiO and Ni(OH)(2) porous nanoplates with the similar morphology have also been synthesized from the same precursor. Benefitting from their structural merits and the in situ formed catalytically active oxidized nickel species, the as-derived nickel phosphides manifest excellent electrocatalytic activity for OER superior to NiO and Ni(OH)(2).</P>

Hybrid-Fiber-Reinforced Composite Boards Made of Recycled Aramid Fibers: Preparation and Puncture Properties

Yu-Chun Chuang,Limin Bao,Ching-Wen Lou,Jia-Horng Lin 한국섬유공학회 2019 Fibers and polymers Vol.20 No.2

Protective textiles require massive consumption of fibers and fabrics, which is responsible for diverse highstrength fabric waste. Wrongly arranged disposal of textile waste is equivalent to the waste valuable resource while causing environmental pollutions. Aramid selvages are worthwhile recycling and used in this study. They are scattered into Aramidstaple fibers and mixed with low melting point polyester (LMPET) fibers to form the Aramid matrices employing the nonwoven process. The matrices are added to different combinations to form Aramid composite matrices and hybrid-fiberreinforced composite boards. The process of shearing, crowding, and friction helps improve the mechanical properties of the composite boards according to the evaluations of conducted tests. With the premise of minimum damage to the fibers, this study uses recycled Aramid waste to produce composite boards that have features of high performance and low productioncost. As a test result, the hybrid-fiber-reinforced composite boards with 90 wt% of recycled Aramid fibers have the optimal mechanical property and static puncture resistance.