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Yu Jongwook,Park Soo Jung,Kim Hyung Wook,Lim Yun Jeong,Park Jihye,차재명,Ye Byong Duk,Tae Oh Kim,Kim Hyun-Soo,Lee Hyun Seok,Jung Su Young,Kim Youngdoe,Choi Chang Hwan 거트앤리버 소화기연관학회협의회 2022 Gut and Liver Vol.16 No.5
Background/Aims: Golimumab has been used for patients with ulcerative colitis (UC) since 2013. However, there is limited data on the effectiveness and safety of the real-world use of golimumab in Asian patients. Methods: This was a multicenter, prospective, observational study. We enrolled patients with moderate-to-severe UC who were administered subcutaneous golimumab at 46 medical centers between May 2014 and November 2019. The primary outcome was the effectiveness and safety of golimumab at week 22. Clinical outcomes and adverse events were assessed according to partial Mayo score at weeks 0, 2, 6, 14, and 22. Results: A total of 130 patients were included (mean age: 45.7±16.0 years). The clinical response/ remission rates at weeks 2, 6, 14, and 22 were 40.4%/22.9%, 56.0%/35.8%, 70.6%/49.5%, and 67.9%/48.6%, respectively. Based on full Mayo score at week 14, clinical response and remission rates were 84.2% and 39.5%, respectively. Mucosal healing rate was 65.8%. In multivariate analysis with logistic regression, longer disease duration was significantly associated with a higher clinical response rate (adjusted odds ratio [aOR], 1.136; 95% confidence interval [CI], 1.006 to 1.282; p=0.040 at week 6; aOR, 1.256; 95% CI, 1.049 to 1.503; p=0.013 at week 22). A higher baseline Mayo endoscopic subscore was significantly associated with a lower clinical response rate at week 6 (aOR, 0.248; 95% CI, 0.089 to 0.692; p=0.008). The incidence of adverse drug reactions was 4.6% (6/130, nine events). No serious unexpected adverse drug reactions or deaths were reported. Conclusions: Golimumab was effective and safe as an induction and maintenance treatment for Korean patients with moderate-to-severe UC.
Iterative Interstream Interference Cancellation for MIMO HSPA+ System
Yu, Hyoug-Youl,Shim, Byong-Hyo,Oh, Tae-Won The Korea Institute of Information and Commucation 2012 Journal of communications and networks Vol.14 No.3
In this paper, we propose an iterative interstream interference cancellation technique for system with frequency selective multiple-input multiple-output (MIMO) channel. Our method is inspired by the fact that the cancellation of the interstream interference can be regarded as a reduction in the magnitude of the interfering channel. We show that, as iteration goes on, the channel experienced by the equalizer gets close to the single input multiple output (SIMO) channel and, therefore, the proposed SIMO-like equalizer achieves improved equalization performance in terms of normalized mean square error. From simulations on downlink communications of $2{\times}2$ MIMO systems in high speed packet access universal mobile telecommunications system standard, we show that the proposed method provides substantial performance gain over the conventional receiver algorithms.
Ok-Tae Kim,Kyong-Hwan Bang,Young-Chang Kim,Yu-Su Shin,Dong-Yun Hyun,Byong-Yel Yeon,Yeoung-Seuk Bae,Nak-Sul Seong,Seon-Woo Cha 한국작물학회 2007 한국작물학회 학술발표대회 논문집 Vol.2007 No.11
Objectives Here, we report the effect of overexpression of ginseng farnesyl diphosphate synthase on the transcription of three key regulatory enzymes involved in triterpene metabolism in hairy root of ginseng and Centella asiatica (L.) Urban. Materials and Methods A four-year-old root of Panax ginseng C.A. Meyer and Centella asiatica (L.) Urban whole plants were obtained from National Institute of Crop Science (Suwon, Korea) and Chonnam National University (Gwangju, Korea), respectively. Agrobacterium rhizogenes R1000 strain was kindly provided by Dr. In (Nongwoo Bio, Yeju, Korea). Results and Discussion The role of farnesyl diphosphate synthase (FPS) in triterpene biosynthesis (Fig. 1) was investigated. A pCAMBIA3101 vector was used to insert a exogenous gene into target plant genome (Fig. 2). After the transformation, we produced Panax ginseng and Centella asiatica hairy roots by introducing the coding region of the gene from Panax ginseng. In these hairy roots, integration of the transgenes into the C. asiatica nuclear genome was confirmed by PCR analysis using PgFPS (P. ginseng FPS) primers and by Southern hybridization using PgFPS-specific probe. FPS specific activity is increased 4-fold compared to controls. In RT-PCR analysis, overexpression of PgFPS in hairy roots was observed (Fig. 3) and two genes, cycloartenol and beta-amyrin synthase, related to triterpene biosynthesis were up-regulated. These results suggest that FPS overexpression might lead to an enhanced biosynthesis of triterpene saponins and phytosterols. However, we did not demonstrate whether or not the introduction of PgFPS gene in Centella asiatica genome directly enhances triterpene saponin production, although our results showed that gene expression related to triterpene saponin biosynthesis were obviously up-regulated. Therefore, additional experiments such as overexpression of FPS gene in triterpene saponin-deficient mutant plants will be required.
선택실험법을 이용한 대중국 수출용 쌀 유기인증의 가치추정 - 중국 서북권역 중심으로 -
유창환 ( Yu Chang-hwan ),김태균 ( Kim Tae-kyun ),이병서 ( Lee Byong-seo ) 한국식품유통학회 2017 食品流通硏究 Vol.34 No.4
The objectives of this study are to analyze the preference of Korean rice by attribute in northwestern China consumers(Xian) by the Choice Experiment(CE) method, to identify factors that can induce the consumers to select the Korean rice, and to suggest plan for maximizing the effect of export strategy. For the purpose, of this study, We conducted consumer surveys of 701 northwestern Chinese consumers. When comparing rice from korea, China and japan, there was a statistically significant difference in the level of organic certification in the coefficient of price. However, there was no significant difference in the country of origin and the type of packaging. These results suggest that rice consumers in the northwestern region of China consider safety and price as important factors rather then their origin and type of packaging. As a result of the analysis of additional Willingness To Pay(WTP) amount based on the certification level using the conditional logit model estimation coefficient, 51 yuan / 2kg was the additional WTP with the Chinese rice certified as organic. The additional WTP with the Korean(Japanese) rice certified as organic 42 yuan / 2kg(45 yuan / 2kg), respectively. Furthermore, the additional WTP is 64 yuan / 2kg in the case the Korean rice is certified as organic by Korea and China. In the case the Japanese rice is certified by Japan and China, the additional WTP is 67 yuan / 2kg. It is considered that the organic certification of the Chinese is the most important compared to that of two others, since the additional WTP of the Chinese organic certification is higher. In addition, when Korean organic certification is added to Chinese organic certification, consumers' satisfaction of the double certification is higher than that of the single. However, the purchase intention decreases as the price increases, since the price coefficient is negative(-). As Chinese consumers regard food safety as important, it is necessary to meet their demand for safety through obtaining various certificates. Export maximization deserves much consideration by developing high-value rice products(rice processed products, functional rice, etc).
Ahn, Tae-Hwan,Yun, Byong-Jo,Jeong, Jae-Jun,Kang, Kyoung-Ho,Park, Yu-Sun,Cheon, Jong,Jerng, Dong-Wook Elsevier 2014 INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER - Vol.79 No.-
<P><B>Abstract</B></P> <P>A new condensation heat transfer model package was developed to improve the prediction capability of one-dimensional best-estimate safety analysis code in a nearly-horizontal tube. The new model package consists of a one-dimensional separated momentum conservation model, an interface shape prediction model, a flow regime prediction model, and a condensation heat transfer coefficient model. The condensation heat transfer coefficient model is composed of a convective heat transfer model and a film condensation model that considers the effects of interfacial shear stress resulting from a high convective steam flow. Therefore, it can mechanistically take into account the heat transfer phenomena that are generated in the upper and lower parts of the tube under separated flow conditions. The developed condensation heat transfer model package was evaluated and verified by using available experimental data obtained from horizontal and nearly-horizontal tubes under the air–water and steam–water conditions. From a quantitative point of view, evaluation results confirmed the improvement of the prediction performance of the new condensation heat transfer model package when there is no non-condensable gas and at sufficiently high pressure.</P>
도시하수 처리에 의한 미생물 오염의 제거효과에 관한 조사연구(I) -청계천 하수처리장을 중심으로-
유병태,정용,Yu Byong Tae,Chung Yong 대한환경위생공학회 1988 대한환경위생공학회지 Vol.3 No.1
This investigation was carried out to evaluate the removal effect of biological contaminants for the municipal sewage treatment process at Cheonggye Cheon terminal plant which in the first plant for municipal sewage treatment in Seoul area. It was conducted in raw influent, primary treatment water and secondary treatment water from September, 1986 to July, 1987. The results were as follow; 1, The primary treatment could eliminate microbials for $65.38\%$ of total bacteria, $64.35\%$ of total coliform, $62.16\%$ of fecal coliform $69.48\%$ of pseudomonas and $64.70\%$ of fecal streptococci in averages for a year respectively. 2. The secondary treatment could eliminate microbials for $97.50\%$ of total bacteria, $97.30\%$of total coliform, $95.95\%$ of fecal coliform, $97.00\%$ of pseudomonas and $96.53\%$ of fecal streptococci in average for a year respectively. 3. In the detect rate of pathogenic agent, salmonella spp was decreased $12.5\%$ to $4.2\%$ in primary treatment and it was not detected in secondary treatment, shigella spp was detected $4.2\%$ in influent water but it was not detected in primary and secondary treatment. 4. In the seasonal variation of treatment effect, the removal of summer was the highest, and the removal of all item in winter was lower than the other seasons. 5. There was significant correlation between water temperature and microbal all items (P<0.05) $NH_3-N$ and Microbal items (P< 0.01) at raw water.