Comparison of trophic factors changes in the hippocampal CA1 region between the young and adult gerbil induced by transient cerebral ischemia.

Yan, Bing Chun,Park, Joon Ha,Kim, Sung Koo,Choi, Jung Hoon,Lee, Choong Hyun,Yoo, Ki-Yeon,Kwon, Young-Geun,Kim, Young-Myeong,Kim, Jong-Dai,Won, Moo-Ho Kluwer Academic/Plenum Publishers 2012 Cellular and molecular neurobiology Vol.32 No.8

<P>In the present study, we investigated neuronal death/damage in the gerbil hippocampal CA1 region (CA1) and compared changes in some trophic factors, such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), in the CA1 between the adult and young gerbils after 5 min of transient cerebral ischemia. Most of pyramidal neurons (89%) were damaged 4 days after ischemia-reperfusion (I-R) in the adult; however, in the young, about 59% of pyramidal neurons were damaged 7 days after I-R. The immunoreactivity and levels of BDNF and VEGF, not GDNF, in the CA1 of the normal young were lower than those in the normal adult. Four days after I-R in the adult group, the immunoreactivity and levels of BDNF and VEGF were distinctively decreased, and the immunoreactivity and level of GDNF were increased. However, in the young group, all of their immunoreactivities and levels were much higher than those in the normal young group. From 7 days after I-R, all the immunoreactivities and levels were apparently decreased compared to those of the normal adult and young. In brief, we confirmed our recent finding: more delayed and less neuronal death occurred in the young following I-R, and we newly found that the immunoreactivities of trophic factors, such as BDNF, GDNF, and VEGF, in the stratum pyramidale of the CA1 in the young gerbil were much higher than those in the adult gerbil 4 days after transient cerebral ischemia.</P>

고령자 (고령자) 십이지장 궤양 (궤양)

정준모(Joon Mo Chung),정극수(Keuk Soo Chung),최용환(Yong Hwan Choi),김인호(In Ho Kim),김효석(Hyo Seuk Kim),김영재(Young Jae Kim) 대한소화기학회 1982 대한소화기학회지 Vol.14 No.1

N/A Clinical studies on patients with duodenal ulcer who visited endoscopy room of Kyungpook National University Hospital since 1976 were performed. Among these patients, we compared the number of patients with gastric or duodenal ulcer yearly, and some aspects of difference between 57 cases of old age(above 60 years) and 129 cases of young age(under 30 years) patients with duodenal ulcer. The results obtained were as follows. 1) In examined cases, number of patients with duodenal ulcer was progressively increased year by year and number of gastric ulcer was more prevalent than that of duodenal ulcer unti11979 when the ratio of gastric and duodenal ulcer became nearly same, and thereafter duodenal ulcer cases were begun more predominant about 2 times that of gastric ulcer in 1981 2) Comparing the sex distribution of old and young age group, male was predominant about 12 times of female cases in young age group and about 2.5 times in old. 3) Overall complications including bleeding, perforation, obstruction and others were seen in 63. 2% of old age group and in 48.1% of young. 4) In 8 weeks follow up cases that was possible although it was least in number, 8 cases were improved or healed in old age group but 5 cases out of 18 cases in young revealed no improvement by ordinary regimen.

Microstructure, Tensile and Fatigue Properties of Al–5 wt.%Mg Alloy Manufactured by Twin Roll Strip Casting

Joon‑Young Heo,Min‑Seok Baek,Kwang‑Jun Euh,Kee‑Ahn Lee 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.5

This study investigated the microstructure, tensile and fatigue properties of Al–5 wt.%Mg alloy manufactured by twin rollstrip casting. Strips cast as a fabricated (F) specimen and a specimen heat treated (O) at 400 °C/5 h were produced andcompared. In the F specimen, microstructural observation discovered clustered precipitates in the center area, while in theO specimen precipitates were relatively more evenly distributed. Al, Al 6 (Mn, Fe), Mg 2 Al 3 and Mg 2 Si phases were observed. However, most of the Mg 2 Al 3 phase in the heat-treated O specimen was dissolved. A room temperature tensile test measuredyield strength of 177.7 MPa, ultimate tensile strength of 286.1 MPa and elongation of 11.1% in the F specimen and167.7 MPa (YS), 301.5 MPa (UTS) and 24.6% (EL) in the O specimen. A high cycle fatigue test measured a fatigue limit of145 MPa in the F specimen and 165 MPa in the O specimen, and the O specimen achieved greater fatigue properties in allfatigue stress conditions. The tensile and fatigue fracture surfaces of the above-mentioned specimens were observed, and thisstudy attempted to investigate the tensile and fatigue deformation behavior of strip cast Al–5 wt.%Mg based on the fi ndings.

Assessment of Alcohol Level in Inebriated Victims of Sexual Assault using Ethyl Glucuronide

Young?Hoon Jo,Mia Kwon,Joon-Bae Lee,Jeong A Ko 한국분석과학회 2022 학술대회논문집 Vol.2022 No.5

비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

Effects of Humidity on the Microstructure and the Ferroelectric Properties of Sol-Gel grown P(VDF-TrFE) Films

Young Joon Ko,진다운,Dae Sol Kong,Jong Hoon Jung 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.76 No.4

We report the microstructure and the ferroelectric properties of poly(vinylidene fluoride-trifluoroethylene) [P(VDF-TrFE)] films grown under various humidity conditions and synthesis times by using a sol-gel method. When the synthesis time under a humid condition was short (approximately 30 min), the moisture in the environment affected only the surface morphology without any loss of ferroelectricity for the P(VDF-TrFE) films. In contrast, when the synthesis time was long (approximately 90 min), the moisture strongly affected the microstructure and the ferroelectric properties of P(VDF-TrFE). The transparent P(VDF-TrFE) film became opaque at high humidity. Scanning electron microscopy revealed numerous pores on the surface of and inside the film. The pores reduced the Young's modulus considerably from 4.15 to 0.97 GPa for the films grown at 20 and 80% relative humidity, respectively. In addition, the ferroelectric hysteresis loop disappeared at humidities above 60%. This work provides upper limits for the humidity and the synthesis time for the growth of high-quality P(VDF-TrFE) films by using a sol-gel method.

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

포도당과 이소프로테레놀에 의한 시상하부의 소마토스타틴 분비가 갑상선자극호르몬방출호르몬에 의한 갑상선자극호르몬에 미치는 효과

박철영,양인명,오승준,김덕윤,우정택,김성운,김진우,김영설,최영길 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.4·5

진행성 위암과 동반된 후복막 섬유화증 7예의 임상적 고찰

장재영,천영국,최우봉,김진오,조주영,이준성,이문성,심찬섭 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Background/Aims: Retroperitoneal fibrosis is a fibrosing disease process which frequently develops ureteral obstruction. Malignant retroperitoneal fibrosis has been reported that various types of cancer including cancer of the breast, stomach, prostate, lung, cervix, uteri, colon, pancreas, ovary, and even Hodgkin's disease. While the pathogenesis remains obscure, small foci of metastatic neoplasm in the retroperitoneal space can elicit a desmoplastic reaction in secondary form to malignancy. Methods: Recently we experienced 7 cases of retroperitoneal fibrosis with advanced gastric cancer. So, we report 7 cases of retroperitoneal fibrosis with clinical and radiologic characteristics. Results: The most common signs and symptoms were related irreversible renal dysfunction. The urologic finding noted medial deviation of the involved ureters and hydronephrosis Conclusions: Clinical manifestations are abdominal pain, back pain, hydronephrosis, and uremia. When sudden back pain and hydronephrosis develop in advanced malignancy, physicians should be considerd for retroperitoneal fibrosis.

시각의 노화를 고려한 노인종합복지관의 색체계획에 관한 연구

정준수,임환준,이현희,박용환 대한건축학회 2003 대한건축학회논문집 Vol.19 No.7

As human become aged, he become color weak due to yellowed eye sight. The 87% of information for human behavioral decisions are visually perceived. Therefore, the color weakness will affect his behaviors in many ways. Most of previous research regarding color planning for the aged people focuses on discovering their preferred colors and reflecting the colors on facility color planning. But these research failed to identify confused range of color cognitions due to the color weakness of the aged. In this research, targeting the aged in multi-purpose senior centers, we analyze their color distinctions and confusions using computer graphic tools. Our research discovers several important points. First, there are differences in color cognitions between the young facility designers/staffs and the aged facility residents. Second, these differences lead to the differences in the abilities of spatial cognitions between the young and the aged. Third, the difference in the spatial distinctions if mainly caused not by color itself but by color adjacencies. Based upon these findings, we propose that color planning of facilities for the aged be made not from the view of the designers but from the view of the aged, considering yellowed eye sight of the aged.