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( Eun Hye Lee ), ( Ah Young Leem ), ( Sang Hoon Lee ), ( Joo Han Song ), ( Song Yee Kim ), ( Kyung Soo Chung ), ( Ji Ye Jung ), ( Moo Suk Park ), ( Young Sam Kim ), ( Joon Chang ), ( Young Ae Kang ) 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-
Background: The prevalence of nontuberculous mycobacteria lung disease (NTM-LD) is increasing worldwide. However, there is limited information about the NTM-LD of young age people. Methods: Patients diagnosed with NTM-LD at severance hospital between January 2006 and December 2016 were retrospectively reviewed. Clinical characteristics and microbiologic features of patients under 40 years were compared with patients over 40 years. Results: Total 906 patients were identified NTM-LD. Of these, 29 patients (3.2%) were under 40 years of age (young age group) and the remaining 877 were over 40 years of age (old age group). Mean age of the two groups were 32 (IQR 24-33) and 64 (IQR 56-72), respectively. Female was predominant in both groups and about half of the patients had a history of tuberculosis (51.7% vs.51.5%, p=0.984). 7 patients (24.1%) of the young age group had malignancy history and among them, 6 patients were hematologic cancer who subsequently received bone marrow transplantation. The proportion of the nodular bronchiectatic form of NTM-LD is significantly higher in old age group (67.5%) compared to young age group (31.0%) (p=<0.001). M.avium complex (MAC) was the most common etiologic organism in both groups, however, it was less common in the young age group (44.8% vs. 65.3%, p=0.023). Identification of M.abscessus complex (MABC) was higher in young age group although statistically insignificant (24.1% vs. 17.0%, p=0.318). Conclusion: This study could help to better understand the characteristics and microbial features of NTM-LD of young age people.
김수현 ( Soo Hyun Kim ), 이아름 ( Ahreum Lee ), 김수지 ( Suji Kim ), 김경조 ( Kyeong Jo Kim ), 권오준 ( Ojun Kwon ), 최준영 ( Joon Young Choi ), 구진숙 ( Jin Suk Koo ), 노성수 ( Seong-soo Roh ) 대한본초학회 2017 大韓本草學會誌 Vol.32 No.4
Objectives : Advanced glycation end products (AGEs) is bind formation of glucose and protein. Acceleration of AGE formation during hyperglycemia is associated with the pathogenesis of diabetic complications and causes kidney and skin damage. The aim of this study was investigated the AGEs inhibitory activity and antioxidant activity of water extracts from young persimmon (YP) and heated young persimmon (HYP). Methods : Paeoniae Radix Alba (YP) is prepared by heating with 30% ethanol. AGEs formation inhibitory activities of YP and HYP measured using bovine serum albumin. To evaluate the protective effects of YP and HYP in diabetic rats induced with streptozotocin (STZ) and methyl glyoxal (MGO), SD rats were distributed into four groups; normal mice (Nor), AGEs-induced rats (Con), AGEs-induced rats treated with 100 ㎎/㎏ YP (YP), AGEs-induced rats treated with 100 ㎎/㎏ heated YP (HYP) for 3weeks. Heated young persimmon respectively decrease AGEs construction. Results : YP and HYP administration inhibited the biomarkers of AGEs in serum, kidney and skin tissues. AGE-induced rats revealed that the significant decreased collagen however, heat processing methods of young persimmon up regulated inhibits AGEs-induced collagen decrease. The expressions of AGEs were decreased in YP and HYP treated group compared with the control group in tissues. It specifies that HYP has potential to serve as a positive regulator of via AGEs path way. Conclusion : It has proposed that may have an improvement effect on diabetic complications, heated young persimmon has AGEs inhibitory excellent activities and antioxidant effect.
( Joon Young Choi ), ( Hea Yeon Lee ), ( Ji Young Kang ), ( Seung Joon Kim ), ( Seok Chan Kim ), ( Sook Young Lee ), ( Young Kyoon Kim ), ( Hwa Young Lee ), ( Kyoung Hoon Kim ), ( Dong Gun Lee ), ( Chin Kook Rh) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Cytomegalovirus(CMV) pneumonia is uncommon in hematologic malignancy patients and clinical feature has been unclear. Methods: The clinical features of 16 patients with hematologic malignancy who were diagnosed as CMV pneumonia from August 2008 to July 2014 were retrospectively analyzed. Results: 43% (7/16) patients were female and average age was 42.5. All patients were performed bronchoscopy at the time of diagnosis. CMV PCR titer from bronchial washing fluid ranged from 6.71 x 103 to 1.5 × 108 copies/ml, and mean value was 9.74 × 106 copies/ml. CMV culture from bronchial washing fluid was positive in 43% (7/16) patients. Cytology from bronchial washing fluid was consistent with CMV virus in 1 case and lung biopsy was done in 4 cases to confirm CMV pneumonia. 75% (12/16) patients with CMV pneumonia had coinfection (5 cases of bacteria, 3 of virus, 2 of pneumocystosis, 4 of aspergillosis, 1 of tuberculosis, 1 of non-tuberculosis mycobacteria, 1 of mycoplasma). 62% (10/16) patients had undergone hematopoietic stem cell transplantation and only 1 patient was in nadir state. All patients were treated with antiviral agent in CMV pneumonia patients. Ganciclovir was used as first line agent in 87% (14/16) patients and 4 patients had changed medication to foscarnet due to treatment failure or complication of ganciclovir. 12% (2/16) patients were treated with foscarnet as first line therapy. 25% (4/16) patients received CMV immunoglobulin. 28-day mortality was 50%. Conclusions: CMV pneumonia is one of the most fatal conditions rarely accompanied in hematologic patients. We analyzed clinical feature in hematologic malignant patients with CMV pneumonia including bronchoscopic findings, coinfection, treatment and prognosis.
( Joon Young Choi ), ( Hea Yeon Lee ), ( Ji Young Kang ), ( Seung Joon Kim ), ( Seok Chan Kim ), ( Sook Young Lee ), ( Young Kyoon Kim ), ( Hwa Young Lee ), ( Kyoung Hoon Kim ), ( Dong Gun Lee ), ( Chin Kook Rh) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Cytomegalovirus(CMV) pneumonia is uncommon in hematologic malignancy patients and clinical feature has been unclear. Methods: The clinical features of 16 patients with hematologic malignancy who were diagnosed as CMV pneumonia from August 2008 to July 2014 were retrospectively analyzed. Results: 43% (7/16) patients were female and average age was 42.5. All patients were performed bronchoscopy at the time of diagnosis. CMV PCR titer from bronchial washing fiuid ranged from 6.71 x 103 to 1.5 x 108 copies/ml, and mean value was 9.74 x 106 copies/ml. CMV culture from bronchial washing fiuid was positive in 43% (7/16) patients. Cytology from bronchial washing fiuid was consistent with CMV virus in 1 case and lung biopsy was done in 4 cases to confirm CMV pneumonia. 75% (12/16) patients with CMV pneumonia had coinfection (5 cases of bacteria, 3 of virus, 2 of pneumocystosis, 4 of aspergillosis, 1 of tuberculosis, 1 of non-tuberculosis mycobacteria, 1 of mycoplasma). 62% (10/16) patients had undergone hematopoietic stem cell transplantation and only 1 patient was in nadir state. All patients were treated with antiviral agent in CMV pneumonia patients. Ganciclovir was used as first line agent in 87% (14/16) patients and 4 patients had changed medication to foscarnet due to treatment failure or complication of ganciclovir. 12% (2/16) patients were treated with foscarnet as first line therapy. 25% (4/16) patients received CMV immunoglobulin. 28- day mortality was 50%. Conclusions: CMV pneumonia is one of the most fatal conditions rarely accompanied in hematologic patients. We analyzed clinical feature in hematologic malignant patients with CMV pneumonia including bronchoscopic findings, coinfection, treatment and prognosis.
( Hwa Young Lee ), ( Joon Young Choi ), ( Se Won Kim ), ( Ji Young Kang ), ( Seung Joon Kim ), ( Sook Young Lee ), ( Seok Chan Kim ), ( Young Kyoon Kim ), ( Jong Wook Lee ), ( Dong Gun Lee ), ( Chin Kook Rhee ) 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-
Background: This study was designed to investigate the utility of CMV quantitative real-time PCR (qRT-PCR) in bronchial washing fluid and define the viral load cut-off values to discriminate CMV pneumonia from infection. Methods: From Mar 2009 to Jun 2014, a total of 565 CMV qRT-PCR was performed on bronchial washing fluid from patients with hematologic malignancies to isolate the pathogen of pneumonia in Seoul St. Mary's hospital. Results: Among the 565 specimen, 101 of CMV qRT-PCR were positive. Twenty-four were diagnosed CMV pneumonia, 70 were CMV infection, and 7 were excluded due to the diagnosis of proven invasive pulmonary aspergillosis rather than viral pneumonia. Of the 24 patients, 8 (33.3%) had acute leukemia and 16 (66.7%) were post-bone marrow transplantation (BMT) status including 2 autologous transplantations. Ten patients (41.7%) were improved after the treatment, 28-days mortality was 45.8%. Median CMV qPCR result was 1.8 Ⅹ 105 copies/mL in CMV pneumonia patients and 3.0 Ⅹ 103 copies/ml in CMV infection (P < 0.01). Using the Receiver operating characteristic (ROC) curve, optimal inflection point was found at 28,774 copies/mL with 75% of sensitivity and 88.6% of specificity (AUC 0.908, P < 0.01). Conclusion: The titers of CMV qRT-PCR in bronchial washing fluid were statistically different between the patients diagnosed CMV pneumonia and infection and whole blood CMV qRT-PCR loads were six times higher in CMV pneumonia group. Cut-off value of 28,774 copies/mL could suggest the point to correlate CMV qRT-PCR in bronchial washing fluid to CMV pneumonia.
The purpose of this study was to investigate the effects of positive reinforcement and fading procedure on letter learning of young preschool children. In order to pursue the purpose, three null hypotheses Mere established as follows : firstly, there is no significant difference in letter learning of young children between the reinforcement conditions ; secondly, there is no significant difference in letter learning of young children between the presentation conditions of reading materials ; finally, there is no significant interaction in letter learning of young children between the reinforcement conditions and presentation conditions of reading materials. A 2 × 4 factorial design with repeated measures on the second factor was employed. The 20 preschool subjects, identified as non-readers, were randomly assigned to the two levels of reinforcement conditions. Then, the reading responses of each subject in each group were repeatedly observed under the four different presentation conditions of reading materials. The four conditions were operationalized as flash-card reading programs that involved picture-letter cards, letter-sound cards, fading cards, and a control condition. And, these materials were computerized and presented individually to each subject through the 14˝ black and white monitor. The findings of the study revealed that : (1) there was no significant difference in letter learning of young children between the positive reinforcement and no-reinforcement conditions : (2) there was significant difference in letter learning between control condition and each of the three presentation conditions, between the picture-letter and letter-sound, and picture-letter and fading conditions, but not between letter-sound and fading procedure ; (3) there was an interaction effect between the two factors. Consequently, the main effects may be interpreted with partial modification : positive reinforcement was significantly more effective in the letter-sound condition ; there was no significant difference in the no-reinforcement condition between the picture-letter and control conditions ; there was significant difference in the positive reinforcement condition between the letter-sound and fading conditions, but not between the picture-letter and fading conditions.
조은영 ( Eun Young Cho ), 정명호 ( Myung Ho Jeong ), 윤현주 ( Hyun Ju Yoon ), 김용철 ( Yong Cheol Kim ), 손석준 ( Seok-joon Sohn ), 김민철 ( Min Chul Kim ), 심두선 ( Doo Sun Sim ), 홍영준 ( Young Joon Hong ), 김주한 ( Ju Han Kim ), 안영근 ) 대한내과학회 2018 대한내과학회지 Vol.93 No.6
목적: 급성 심근경색증 환자에서 좌심실 이완 기능과 좌심실 충만압은 환자의 예후와 관련되어 있다고 알려져 있다. 이 연구의 목적은 젊은 급성 심근경색증 환자에서 좌심실 이완 기능 저하 및 충만압 상승에 따른 임상 경과의 차이를 파악하고자 하였다. 방법: 2011년 1월부터 2015년 8월까지 Korea Acute Myocardial Infarction Registry-National Institute of Health (KAMIR-NIH)에 등록된 환자 중 젊은 급성 심근경색증(남 < 45세, 여 < 55세)으로 전남대학교병원에 입원한 환자 240명중에서 관상동맥중재술을 시술받고 2년 동안 임상 추적 관찰이 되어 분석 가능한 환자 200명(남 : 여 = 160명 : 40명)을 대상으로 하였다. 200명의 환자를 좌심실 이완 기능이 정상인 군(46명, 39.5 ± 5.3세)과 비정상군(154명, 43.5 ± 5.1세)으로 나누었다. 좌심실 충만압을 측정하였으며, 좌심실 충만압 상승을 E/e' ratio 15 이상으로 정의하였다. 좌심실 이완 기능 정상군과 비정상군으로 나누었고 정상 좌심실 충만압군과 좌심실 충만압 상승군으로 나누어 각각 주요 심장 사건을 분석하였다. 주요 심장 사건은 사망, 심근경색증의 재발 및 재관류술로 정의하였다. 결과: 연구 대상자를 평균 40.9 ± 11.6개월 동안 임상적으로 추적 관찰한 결과, 이 중 26명(13%)에서 사망, 심근경색증 재발 및 재관류등의 주요 심장 사건이 발생하였고, 좌심실 이완 기능 정상군과 비정상군 간의 유의한 차이는 없었다(p = 0.810). 또한 좌심실 이완 기능을 정상군과 1도 이완기 기능 장애군과 2도 이완기 기능 장애군으로 나누어서 추가 분석하였다. 2도 이완기 기능 장애군에서 심근경색증 재발은 유의한 차이를 보였지만(p = 0.006), 주요 심장 사건과 유의한 차이는 없었다(p = 0.081). 그러나 좌심실 충만압 상승군에서 정상 좌심실 충만압을 가진 환자군에 비하여 주요 심장 사건의 발생률은 유의한 차이가 있었다(p < 0.001). 다변량 분석 결과 주요 심장 사건 발생의 독립적인 인자는 E/e' ratio 15 이상 환자로 파악되었다(p = 0.019). Kaplan-Meier 생존 곡선을 이용한 사망률을 추적한 결과 좌심실 수축 기능 40% 미만인 환자(p < 0.001)와 E/e' ratio 15 이상 환자(p = 0.004)에서 유의하게 생존율이 낮았다. 결론: 높은 좌심실 충만압은 젊은 급성 심근경색증 환자의 예후에 대한 독립적 예측 인자였으며, 좌심실 충만압의 측정은 젊은 급성 심근경색증 환자에서 심근경색증 후 고위험 환자군 분류에 유용할 것으로 기대된다. Background/Aims: The impact of left ventricular (LV) diastolic function and filling pressure on clinical outcomes in young patients with acute myocardial infarction (AMI) has been poorly studied. Therefore, the aim of this study was to investigate the impact of LV diastolic function and LV filling pressure on major adverse cardiac events (MACEs) in young patients with AMI. Methods: A total of 200 young patients (males < 45 year, females < 55 year) with AMI were divided into two groups according to the diastolic function; normal (n = 46, 39.5 ± 5.3 years) versus abnormal (n = 154, 43.5 ± 5.1 years). Results: Despite regional wall motion abnormalities, normal LV diastolic function was not uncommon in young AMI patients (23.0%). During the 40 months of clinical follow-up, MACEs developed in 26 patients (13.0%); 14 re-percutaneous coronary intervention (7.0%), 8 recurrent MI (4.0%), and 4 deaths (2.0%). MACEs did not differ between the normal and abnormal diastolic function group (13.6% vs. 10.9%, p = 0.810), but MACEs were significantly higher in the high LV filling pressure group than the normal LV filling pressure group (36.8% vs. 10.5%, p < 0.001). On multivariate analysis, high LV filling pressure was an independent predictor of MACEs (hazard ratio 3.022, 95% confidence interval 1.200-7.612, p = 0.019). Conclusions: This study suggested that measurement of the LV filling pressure (E/e' ratio) would be useful in the risk stratification of young patients with AMI. However, it would be necessary to monitor this category of patient more carefully. (Korean J Med 2018;93:538-547)
김승영 ( Seung Young Kim ), 임형준 ( Hyung Joon Yim ), 안재홍 ( Jae Hong Ahn ), 정성우 ( Sung Woo Jung ), 김정한 ( Jeong Han Kim ), 김지훈 ( Ji Hoon Kim ), 이주한 ( Ju Han Lee ), 이승화 ( Seung Hwa Lee ), 정환훈 ( Hwan Hoon Chung ), 연종은) 대한간암연구회 2009 대한간암학회지 Vol.9 No.-
Helatocellular carcinoma (HCC) is uncommon in young adults, and young HCC patients is known to show poor prognosis than older HCC patients because they have a more advanced tumor stage at diagnosis. We describe a case of HCC in a 28-year old chronic hepatitis B virus carrier who showed multiple nodular HCC with bone metastasis at diagnosis. In spite of multidisciplinary treatment including transarterial chemoembolization (TACE) for liver mass and radiotherapy for metastatic bone lesion, the patient died of cancer progression and weakened general condition 15 months after diagnosis. Therefore, we need to consider periodic surveillance in young chronic hepatitis B virus carriers.
DNA Fingerprinting of Helicobacter pylori Isolated from Patients with Peptic Ulcer Su Jin Hong, M.D., Yong Soon Park, M.D., Young Hong Lee, M.D., Young Deok Cho, M.D., Jin Oh Kim, M.D., Hyung Keun Bong, M.D., Joo Young Cho, M.D., Joon Seong Lee, M.D., Moon Sung Lee, M.D., Yun Soo Kim, M.D., Seong Gyu Hwang, M.D., and Chan Sup Shim, M.D., Seung Duk Hwang, M.D. * and Hi Bahl Lee, M.D.* Department of Internal Medicine, Digestive Research Institute and Hyonam Kidney Laboratory* Soonchunhyang University College of Medicine, Seoul, Korea Background/Aims: The gastric pathogen Helicobacter pylori establishes long-term chronic infection that can lead to gastritis, peptic ulcers, and gastric cancer. However, little is known about the source and route of infection of this organism, and the mechanism of pathogenicity is only now beginning to be unravelled. Urease might allow the survival of the bacteria in an acidic environment, a prerequisite for colonization. H. pylori is cytotoxic to cultured human gastric epithelial cells and this toxicity is due in part to ammonia produced by hydrolysis of urea. We performed this study to evalute the usefulness of DNA fingerprinting of urease genes as a sensitive epidemiological tool for the typing of H. pylori clinical isolates. Methods: Clinical isolates of H. pylori were obtained by biopsy from 18 patients with peptic ulcer at the time of endoscopic examination. Biopsy tissues were cultured under microaerophilic conditions. DNA of H. pylori were extracted for PCR amplification. This study used the polymerase chain reaction(PCR) to amplify the urease structural subunit genes, ureA and ureB, which, when digested with restriction endonucleases, allow the differentiation of patterns on 1.5% agarose gels. Results: The 2.4 kb PCR products amplified and subjected to Hae Ⅲ restriction endonuclease digestion produced 11 distinct patterns on agarose gels, with five patterns occurring within two or three isolates. Conclusions: The urease genes of H. pylori had genetic heterogeneity, but it could be of considerable tool for epidemiological studies. Moreover the method is useful for studies of relation between H. pylori induced diseases and different strains because unique patterns were shown in two or three isolates. In conclusion, DNA fingerprinting of H. pylori could be available for epidemiological studies of H. pylori infections and for clinical applications. (Korean J Gastroenterol 1997; 29:317 - 325) Key Words : Helicobacter pylori, DNA fingerprinting , Restriction endonuclease digestion, Peptic ulcers 접수: 1996년 7월 24일, 승인: 1996년 10월 11일 연락처 : 심찬섭, 서울특별시 용산구 한남동 657-58, 순천향대학병원 소화기내과학교실
Forty-nine patients less than 40 years of age were diagnosed at Yonsei University Medical Center between 1977 and 19S5 as having lung cancer. Patients less than 40 years old account for approximately 2.3% of all patients. The youngest patient was 20 years old and mean age being 33.7 years old. Sex ratio was 1.3;1 (male: frmale) but under 35 years old, it appeared to be nearly 1:1. Most patients were symptomatic at the time of examinatiion. Thirt-nine per cent had epidermoid carcinoma, 27% had adenocarcinoma and 18% had small cell carcinoma. But under the age of 30, forty-two per cent had epidermoid carcinoma, 50% had adenocarcinoma and 8% had small cell carcinoma. Distant metastasis was more prominent in young adults than in older person, especially in the group under 30 years. We concluded that lung cancer in young person is more virulent and that diagnosis is frequently delayed. In addition, We suggest that age criteria for defining $quot;Young Adult Lung Cancer$quot; would be 35 years in Korea rather than 40 years which being usual in other country. And cytochemical, genetical and immunological approaches should be continued to verify the pathogenetic mechanism plausible for the lung cacer in young adults.