중장년 성인교정환자의 구강상태 및 치료양태에 관한 연구

이현정(Hyeon-Jung Lee),김진영(Jin-Young Kim),조진형(Jin-Hyoung Cho),황현식(Hyeon-Shik Hwang) 대한치과의사협회 2010 대한치과의사협회지 Vol.48 No.5

Orthodontic treatment for middle-aged patients has become more commonplace with various reasons including improved socioeconomic status. Understanding of oral status and treatment modalities of middle-aged patients is mandatory for accurate diagnosis and proper treatment planning. This study investigated 100 consecutive patients aged 40s and 50s and 100 aged 20s who had been examined and diagnosed at the Department of Orthodontics, Chonnam National University Dental Hospital. The results were obtained as follows; 1. Gender distribution showed female outnumbered male patients in young-aged adult patients, but middle-aged patients showed similar male and female distribution. 2. The major concern seeking orthodontic treatment was esthetics not only in young-aged but also in middle-aged adult patients, and a number of middle-aged patients were concerned about oral health as well. 3. Considerable number of middle-aged patients were referred by other dental specialties while young-aged adult patients were more self-motivated for orthodontic treatment. 4. Middle-aged adult patients had more missing teeth and periodontal disease than young-aged adults. 5. The most frequently-observed problem was dental spacing in middle-aged patients while dental crowding in young-aged adult patients. Middle-aged patients showed higher prevalence of deep overbite and overjet while most of young-aged adults presented opposite direction of problem in overbite and overjet. 6. Limited orthodontic treatment was required rather than comprehensive treatment in middle-aged patients, and the most common tooth moving area was anterior part of dentition in case of limited treatment. Need of interdisciplinary therapy with other dental specialties was more common in middle-aged patients. 7. Intervention of specific technique such as invisible TP, passive bracketing, passive wire bonding, and lingual orthodontics was more required in middle-aged patients. Considering that middle-aged patients have different characteristics than young-aged adults, the results of the present study suggest that different treatment modalities are required in middle-aged orthodontic patients in order to manage them properly and efficiently.

Inhibition of oxidative stress induced‑cytotoxicity by coptisine in V79‑4 Chinese hamster lung fibroblasts through the induction of Nrf‑2 mediated HO‑1 expression

Hyeon‑Gyun Jo,Cheol Park,이혜숙,Gi‑Young Kim,Young‑Sam Keum,Jin Won Hyun,Taeg Kyu Kwon,Yung Hyun Choi,Su Hyun Hong 한국유전학회 2021 Genes & Genomics Vol.43 No.1

Background Coptisine is a natural alkaloid compound and is known to have multiple benefcial efects including antioxidant activity. However, whether it can protect lung fbroblasts from oxidative damage has not been studied yet. Objectives To investigate the potential inhibitory efect of coptisine against oxidative stress in V79-4 lung fbroblast cells. Methods V79-4 cells were treated with H2O2 (1 mM) in the presence or absence of coptisine (50 µg/ml), N-acetyl cysteine (NAC, 10 mM) or zinc protoporphyrin IX (ZnPP, 10 µM) for the indicated times. The alleviating efects of coptisine on cytotoxicity, cell cycle arrest, apoptosis, reactive oxygen species (ROS) production, DNA damage, mitochondrial dynamics, and inhibition of ATP production against H2O2 were investigated. Western blot analysis was used to analyze the expression levels of specifc proteins. Results Coptisine inhibited H2O2-induced cytotoxicity and DNA damage by blocking abnormal ROS generation. H2O2 treatment caused cell cycle arrest at the G2/M phase accompanied by increased expression of cyclin-dependent kinase (Cdk) inhibitor p21WAF1/CIP1 and decreased expression of cyclin B1 and cyclin A. However, these efects were attenuated in the presence of coptisine or NAC. Coptisine also prevented apoptosis by decreasing the rate of Bax/Bcl-2 expression in H2O2-stimulated cells and suppressing the loss of mitochondrial membrane potential and the cytosolic release of cytochrome c. In addition, the activation of nuclear factor-erythroid-2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) was markedly promoted by coptisine in the presence of H2O2. However, zinc protoporphyrin IX, a potent inhibitor of HO-1, attenuated the ROS scavenging and anti-apoptotic efects of coptisine. Conclusions Based on current data, we suggest that coptisine can be used as a potential treatment for oxidative stress-related lung disease.

젊은 남성에서 성정체성에 대한 고환의 영향 : 지역 기반 조사 Community-Based Survey

구자현,김민의,이남규,박영호 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.2

We investigated the influence of testis on the gender identity in late adolescent Korean males dwelling in a community. Of 27,202 men aged 20 years dwelling in the community, 2,700 men were randomly selected at a 10.0% sampling fraction. A total of 2,080 men who agreed to participate in the study and all volunteers underwent a standard evaluation. For the evaluation of influences of testis on the gender identity, we used the Bem Sex Role Inventory in the subjects who had testis torsion, testis injury of cryptorchidism as well as with no testicular disease. They were categorized as group 1; normal testis size, group 2; testis atrophy, and group 3; no testis in the scrotum. The median masculinity scores of group 1, 2 and 3 were not significantly different (group 1; 4.3 [3.65.0], group 2; 3.9 [3.1-4.5] and group 3; 4.6 [4.0-5.1], p=0.065). Regarding the femininity score, there were no differences among groups (group 1; 4.6 [4.0-5.1] versus group 2; 4.5 [3.9-4.8] and group 3; 4.6 [4.2-4.9], p=0.609). In group 3, the masculinity and femininity scores were not also different between of men underwent orchiectomy and did not undergo correction of cryptorchidism. We did not find the impact of testis on gender identity in our cohort. Additional research is needed to clarify the underlying psychopathology involved.

Insulation Coating of Fe–Si–Cr Soft Magnetic Powder by Selective Oxidation

Jae‑Young Park,Kwangsuk Park,Bosung Seo,Julien O. Fadonougbo,Tae‑Wook Na,Ki Beom Park,Hyeon‑Tae Im,Nong‑Moon Hwang,Hyung‑Ki Park 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.7

This study examines the insulation coating technology of Fe–Si–Cr powder via selective oxidation annealing, which oxidizeselements selectively by controlling the oxidation potential. The study calculated the oxidation driving force of Fe, Si, andCr, and conducted a thermodynamic analysis of oxidation and reduction conditions according to temperature and oxidationpotential. Based on the results, a selective oxidation annealing was performed in an atmosphere in which Fe is reduced andonly Si and Cr are selectively oxidized. The oxidation potential was controlled through the partial pressure ratio of hydrogenand water vapor. The XPS analysis results confirmed that a Si and Cr complex oxide layer formed on the powder surfaceafter the selective oxidation annealing. Afterward, withstanding voltages were analyzed to evaluate the insulation property. Then, the withstanding voltage of the powder applying the selective oxidation annealing increased significantly comparedto that of the initial powder. Further analysis showed that the powder annealed in an air atmosphere had a significantly lowersaturation magnetic flux density than the initial powder, while the powder applying the selective oxidation annealing hadonly a slightly reduced saturation magnetic flux density.

한국의 판·검사복에 관한 연구

김지현(Ji Hyeon Kim),임영자(Young Ja Im) 한국복식학회 1996 服飾 Vol.29 No.-

This thesis is concerned with the study of the court attire, the typical attire of the judicial world in a point of time that more than 100 years have passed since the introduction of the modern judical system. In recognition of the fact that compiled data of the official uniform or attire in Korea are insufficient, this study placed its signification on the provision of information with focus on attire. As a result of studying court attire in Korean, the conclusion was made as fallows ; Firstly, Official attires in Yi Dynasty were divided by wearing embroidered insignia on the breast andthe back of an official robe according to court rank as well as by wearing Sa-mo (thin silk hat, 紗帽) in wadded clothes of Dan-ryeong(團領) and attaching all sorts of appurtenances(胸背) including bands(帶) and shoes(靴). The Minister of Justice was equipped with Ho-pyo (pattern of tiger and leopard, 虎豹), Dae-sa-heon equipped with Hae-chi (fambulous animal knowing virtue and vices, 해치), the mayor of Seoul (Han-sung-bu`s Pan-yun) equipped with Un-an (wild geese in clouds, 雲雁). In the era of the King Young-jo, the minister of Justice had no change in its official robe, but the mayer (Pan-yun) of Seoul (Han-sung-bu) had Un-an(wild geese in clouds, 雲雁) changed into Un-hak (cranes in the crowd, 雲鶴). In the King Ko-jong era, the minister of Justice (Pan-suh of Hyung-jo) had Ho-pyo (pattern of tiger and leopard, 虎豹) changed into Ssang-ho (a couple of tigrs, 雙虎), and the mayor of Seoul (Han-sung-bu) had Un-hak (cranes in the crowd, 雲鶴) changed into Ssang-hak (a couple of cranes, 雙鶴), on embroideved insignia on the breast and back of an official robe. Laws and regulations concerning court attire began with the In-judgement Full-dress Uniform Requlation for official-level Cleircal Staff below the ordinary staff, the Issue No. 14 of the Royal Ordinance in 1906, provided as 「the matter cincerning the Dress Regulation of the Tibunal staff of the Cho-sun Government-Gerneral」the Issue No. 222 of the Royal Ordinance in 1911, and changed into 「the Regulation on the Dress of Judge, Prosecutor, Attorney and Law Count Clerk」the Issue No. 12 of the Supreme Court Rule in 1953 after the establishment of Korean Government since emancipation from the Japanese rule and into 「the Regulation concerning the Court Attire of Judge and law Court Clerical Staff」, the Issue No. 516 of the Supreme Court Rule in 1966. The judicial system in Korea is the system introduced from the foreign country rather than autogenously developed. And it came to pass through the Japanese colonial period in the beginning that it took root in Korea, and was not stabilized in harmony with our native tradition. Accordingly, the attare regulation in the judicial system took root in our society by accepting the Japanese attire regulation as it was, and judical officials have come to wear the count attire similar to that of the Japanese imperialist era due to its influence though Korean independent government was established together with liberation form the Japanese rule. The more regrettable thing is that the current court attire has maintained the form greatly influenced by the U.S. court attire. Fortunately, as the judicial circles have recently raised their voices for change in the court attire, it has been told that the formation of a meeting for a new court attire has been under way. The birthof the court attire into Which our tradition is sublimated is expected. This study end up with thinking that the must Korean thing is the most global thing in this era that people in the world are clamoring for globalization.

가교정도에 따른 고무복합체의 물리적 특성에 관한 연구

나창운(Chang Woon Nah),김현재(Hyeon Jae Kim),강신영(Shin Young Kaang) 한국고무학회 1998 엘라스토머 및 콤포지트 Vol.33 No.4

N/A Tensile properties including Young`s modulus and tear strength were measured for four different rubber compounds; natural rubber(NR), styrene-butadiene copolymer(SBR), ethylene-propylene dime monomer(EPDM), and brominated isobutylene-p-methyl-styrene copolymer(BIMS) as a function of temperature and degree of cure. To see the effect of over cure, a measurement was made of the tensile strength and swelling behavior of the over-cured rubber compounds. Young`s modulus, E, was found to have linear dependency on the degree of cure for all rubber compounds. EPDM and BIMS showed the highest and lowest slopes, respectively. The slope of NR and SBR lay between EPDM and BIMS. Tear strength, Gc, decreased in the order of NR$gt;BIMS$gt;SBR$gt;EPDM. As the cure time was extended the degree of cure of NR and SBR decreased, while that of BIMS increased. EPDM showed little change in the degree of cure.

췌장염에 의한 가성낭종내에 생긴 가성동맥류 : 1례 보고

오연희,이채경,김승현,이성우,양창현,이정호,이영현 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

만성 췌장염의 합병증으로 생긴 가성동맥류는 드문질환으로, 반복적으로 다량의 출혈을 일으킬 수 있으며, 치료를 하지 않을 경우 사망율이 높기 때문에, 조기 진단과 치료가 필수적이다. 저자들은 38세 남자 환자에서 췌장염의 합병증으로 생긴 가성낭종내에서 발생한 가성동맥류 1예를 경험하였기에 보고하는 바이다. 가성 동맥류의 색혈류도플러상 낭종내에 양방향 흐름의 와류를 볼 수 있었다. Pancreatic Pseudoaneurysm within Pseudocyst from Pancreatitis: 1 Case Department of Diagnostic Radiology and Internal Medicine, College of Medicine,DongGuk University Yeon Hee OH M.D., Chae Kyeong Lee M.D., Seoung Hyeon Kim M.D., Sung Woo Lee M.D., Chang Heon Yang M.D., Jung Ho Lee M.D., Young Hyun Lee M.D. Pseudoaneurysm from pancreatitis is uncommon, but it can cause recurrent and massive hemorrhage. Because of high morbidity and mortality, early detection and treatment of the pseudoaneurysm is needed. We report a case of pseudoaneurysm within pseudocyst from pancreatitis. Color-flow Doppler sonography shows bidirectional flow and turbulent arterial flow, within anechoic mass.

젊은 연령층과 고령층에서 발생하는 뇌동맥류의 임상적 비교연구

전용선,송시헌,고현송,염진영,김성호,김윤 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.8

고도비만 환자에서 복강경 위소매절제술 후 발생한 누공의 내시경 치료 1예

류민선,심기남,조원영,김찬용,강현주,김미연,안소영,이윤표,조형원,정성애,이주호 이화여자대학교 의과학연구소 2013 EMJ (Ewha medical journal) Vol.36 No.2

Laparoscopic sleeve gastrectomy can reduce morbidity and mortality in patients with morbid obesity, but it can cause complications such as a gastrointestinal leak. A 30-year-old morbidly obese female who had type 2 diabetes mellitus and hypertension with estimated body mass index of 40.2 kg/m2 was admitted. Laparoscopic sleeve gastrectomy was performed. On postoperative day 19, a leak was suspicious on physical examination and radiologic findings. Conservative management was performed, but the patient was hemodynamically unstable and imminently septic. After laparoscopic drainage procedure, esophagogastroduodenoscopy was performed and revealed the fistula opening at staple line just below gastroesophageal junction. Fibrin tissue adhesive was injected around the fistula and the esophageal covered stent was inserted to cover the leak. At 14th days after stent insertion, the barium study confirmed no more leak. In this case, we experienced that the esophageal stent insertion with fibrin tissue adhesive injection may reduce recovery time of the fistula developed after laparoscopic sleeve gastrectomy

그레이브스병에서 치료에 따른 폐동맥압의 변화

남택만,조한수,이진서,송영림,김두만,두영철,박철영,정인경,홍은경,이성진,오기원,김현규,유재명,최문기,유형준,박성우 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.5

연구배경: 갑상선기능항진증에 의한 갑상선중독증 환자들은 호흡곤란을 호소하며, 그 원인으로 호흡근의 근력 약화, 좌심실부전으로 인한 폐모세혈관의 울혈, 기도저항의 증가, 갑상선종으로 인한 기관의 압박, 호흡기능 이상 등이 거론되고 있다. 폐동맥고혈압이 동반된 그레이브스병 환자가 여러 증례가 보고되었으며, 폐동맥고혈압 환자에게서 갑상선 자가항체와 갑상선기능저하증의 빈도가 높음이 알려지면서 갑상선중독증이 동반된 그레이브스병 환자에게서 관찰되는 호흡곤란의 한 원인으로 폐동맥압 증가가 작용할 가능성이 제시되고 있다. 이에 저자 등은 그레이브스병 환자를 대상으로 폐동맥압을 측정하고 치료 전후의 폐동맥압의 변화를 전향적으로 연구하였다. 방법: 갑상선중독증이 동반된 그레이브스병 환자와 정상 갑상선기능을 나타낸 대조군을 대상으로 갑상선기능검사 및 갑상선 자가항체를 측정하고, 심초음파를 이용하여 치료 전후로 폐동맥압을 측정하여 폐동맥압과 갑상선기능 및 갑상선 자가항체와의 관계, 폐동맥압의 변화 등을 관찰하였다. 결과: 1. 연구대상은 대조군 10명 (남녀비 1:9, 관해 상태의 그레이브스병 3명, 갑상선종 3명, 정상인 4명), 그레이브스병 환자 26명 (남녀비 7:19)이었다. 2. 대조군과 치료 전 그레이브스병 환자의 폐동맥압은 각각 23.5±2.32 mmHg, 29.6±10.3 mmHg이었고, 치료 전의 폐동맥압과 혈청 갑상선자극호르몬 결합억제 면역글로불린 (TBII) 농도는 유의한 양의 상관관계를 보였다. 3. 26명의 그레이브스병 환자 중에서 10명 (38.5%)이 폐동맥고혈압 (기준: 폐동맥압 > 30 mmHg)으로 진단되었다. 4. 치료 전후로 폐동맥압을 측정한 13명은 폐동맥압이 치료 전 29.6±10.3 mmHg에서 치료 후 폐동맥압 22.2±6.48 mmHg로 의미있게 감소하였다. 결론: 갑상선중독증을 보이는 그레이브스병 환자의 약 40% 정도에서 폐동맥고혈압이 발견되어 폐동맥고 혈압은 그레이브스병에 흔하게 동반하는 질환으로 생각된다. 향후 그레이브스병 환자에서 관찰되는 폐동맥압의 증가와 관련한 병인, 발생기전 및 임상적 의의 등에 대한 연구가 필요할 것으로 생각된다. Background: Exertional symptoms, dyspnea and impaired effort tolerance are common in patients with Graves' disease. Proposed explanations include: high-output left heart failure, ineffective oxygen utilization and respiratory muscle weakness. In addition, pulmonary hypertension has also been reported in patients with Graves' disease. A high prevalence of hypothyroidism and positive thyroid autoantibody were also observed in patients with pulmonary arterial hypertension. Therefore, the pulmonary artery pressure in patients with Graves' disease was evaluated. Methods: Two-dimensional and Doppler echocardiographic examinations (Hewlett Packard Sonos 2500) were performed to determine the pulmonary artery (PA) pressure in 26 Graves' disease patients, both before and after treatment (23 patients with propylthiouracil and 3 with RAI), and in 10 euthyroid controls. The changes in the PA pressure after treatment were evaluated in 13 patients with Graves' disease, who became euthyroid after treatment. Results: The pulmonary artery pressure was increased in the untreated Graves' disease patients compared to the normal controls (23.5±2.32 vs. 29.6±10.3 mmHg). 38.5% of the Graves' disease patients (10/26) showed pulmonary arterial hypertension (PA>30 mmHg) and the serum TBII level was higher in the Graves' disease patients with pulmonary arterial hypertension than in those with normal PA pressure (P<0.05). In the Graves' patients who became euthyroid after treatment, the PA pressure was significantly decreased. Conclusion: 38.5% of the untreated Graves' disease patients showed pulmonary arterial hypertension, and the pulmonary artery pressure was significantly decreased in those who became euthyroid after treatment. The pathogenesis and clinical importance of pulmonary arterial hypertension in Graves' disease requires further studies (J Kor Soc Endocrinol 18:465∼472, 2003).