무갑상선 쥐에서 중식성 반흔의 새로운 실험모델

김영진,이백권,장도명,조길환,임풍 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.4

Proliferative scarring in the form of keloids and hypertrophic scars continues to be a clinical problem for some patients. The lack of an animal model for such scarring has been an obstacle to studying the biology and effective therapy of these entities. Consequently we created an accurate reproductive animal model to systematically study them. Human proliferative scars were explanted into flaps based on isolated vascular pedicles in congenitally rats. We compared the procollagen type Ⅲ peptide levels of proliferative scar tissue before and after explanting. The procollagen type Ⅲ peptide levels of explanted proliferative scar tissue remained increased as before explanting. Histological analysis of the explanted proliferative scar tissue revealed that all explants retained their original histotypic character even after 1 year. We could also retain the volume of implanted proliferative scar for 1 year and studied in vitro cellular proliferation. Fibroblast cultures from explanted scars demonstrated less aggressive growth characteristic than those from original surgical specimens. The advantages of this animal model are as follows: 1. The explants retain their histotypical character for a long period. 2. Placement of the explants outside the dorsum of a nude rat makes serial observation and measurement easier. 3. Agents under test can be injected into the explants through a catheter inserted into a single pedicle of island flap without the possibility of spreading systematically.

성인의 천미추부 종괴

조길환,이백권,장도명,김영진,안상태 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

We developed an animal model to recreate the condition of an open fracture in communication with the maxillary sinus. We then studied wound healing of the sinus wall structures following fracture in the presence of autogenous bone and alloplastic implant. This model is designed to simulate the repair of an orbital floor fracture in humans. The New Zealand White rabbit was used as the animal model. Standardized 8mm defects were made bilaterally in the maxillary sinuses to include bone and mucosa in 36 rabbits. Two different implants and autogenous calvarial bone graft were placed in the soft-tissue pockets to obturate the defects, exposing one surface of the implant to the open sinus. Medpor porous polyethylene, silicone and calvarial bone implant were compared. Animals were killed at 1, 2 and 8 weeks after implantation. Gross examination of the specimens for the amount of mucosal closure and implant tissue fixation was performed. Histological sections were evaluated for bone and soft-tissue morphology juxtaposed to the implant. Complete closure of the mucosal defect was demonstrated with each type of implant. Medpor implants showed both vascular and soft-tissue ingrowth into pores by week 1. Bone ingrowth was seen by week 2. Closure of the Medpor obturated defects occurred more rapidly than in the silicone group. The Medpor implants and calvarial bone demonstrated bone and soft-tissue fixation, callus formation and maturation, while mature overlying mucosa was reconstituted over the defects. Silicone implants demonstrated a fibrous tissue reaction within 1 week of implantation and they never became fixed to bone or soft tissue. Maxillary sinus wall regeneration occurred in all defects. This study supports clinical observations of maxillary sinus wall regeneration in humans. Although sacrococcygeal mass is rare and usually found in infants or children, adolescent or adult patients with protruding mass in sacrococcygeal region occasionally come to us simply for a cosmetic problem. In this situation, even though there is no definite neurological deficit, it should be evaluated whether or not the underlying bony pathology or dural defect exists. Few cases about the sacrococcygeal mass have been reported in adults. We reviewed our cases including preoperative evaluation methods and postoperative diagnosis. From March, 1993 to February, 1997, we experienced 6 adult patients with sacrococcygeal mass and no neurological abnormality. Preoperative evaluation were made by plain X-ray, myelogram, computed tomography(CT), and magnetic resonance imaging (MRI), as needed. Postoperative diagnoses were 2 meningoceles, 2 lipomyelomeningoceles, 1 desmoid tumor, and 1 teratoma. From our experiences, CT or MRI is essential to evaluate the sacrococcygeal mass preoperatively. These methods can visualize the precise anatomic location and extent of the mass, its relation to the spinal cord, and associated bony abnormalities. MRI is superior to CT, especially in defining the nature of the mass and involvement of the spinal cord. Conclusively, even a simple mass in the sacrococcygeal region in adults needs MRI or CT evaluation, and MRI is the most valuable method of evaluating the mass preoperatively and provides important information to establish a treatment plan.

도시하천의 환경 친화적 개선방안에 관한 조사연구

이길영,권득용,김영안,한천규 대전대학교 산업기술연구소 1999 산업기술연구소 論文集 Vol.10 No.1

The three main steams flowing through Taejon have some serious problems to be solved or improved. They are : First, the uniform cross section of the rivers should be changed. Second, the extension of the riverside road should be reconsidered. Third. the neighborhood parks on the flood plain should be modified. Fourth, the flood plain parking place must not be constructed. Fifth, the ecosystem will be destroyed by the structure constructed along the rivers. In this study, we suggest that the investment and research on the development of the new technology for the setting the rivers in natural condition should be needed now and the continuous investigation and long-term plan to preserve the ecosystem of the rivers should be required. The environmental conditions of Taejon-stream, Yudung-stream and Kap-stream are indicators of the standard of living of the citizens in Taejon. Now is the time to reconsider the careless construction around the rivers and to prepare the long-term plan for the protection of the ecosystem and natural environment.

保存血의 腐敗産物에 依한 에틸알콜 生成濃度에 關한 硏究(Ⅱ)

張成吉,金英雲,柳在薰,權五星,朴世延 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

후추(Piper nigrum) 열매의 Alkaloids

박일권,이학주,이상길,신상철,박지두,최돈하,안용준 한국목재공학회 2003 목재공학 Vol.31 No.5

후추 열매의 MeOH추출물로부터 silica gel 및 preparative HPLC 칼럼 크로마토그라피를 이용하여 5종의 알카로이드 화합물을 단리하였으며, NMR, MS 등의 기기분석 결과, N-isobutyl amide alkaloids인 pellitorin (Ⅰ)를 비롯하여, quineensine (Ⅱ), pipercide (Ⅲ), retrofractamide A (Ⅳ)과 piperidine alkaloid인 Pipeline (Ⅴ)으로 각각 동정하였다. Five amide alkaloids were isolated from the fruits of Piper nigrum. The structures were determined as : pellitorin(Ⅰ), quineensine(Ⅱ), pipercide(Ⅲ), retrofractamide A(Ⅳ), and piperine(Ⅴ) respectively on the baiss of spectrosopic data.

生體血의 保存環境과 腐敗産物에 依한 血中알콜濃度變化에 關한 硏究

張成吉,金英雲,柳在薰,吳世珍,權五星,朴世延 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

간석지산 이매패에서의 흡충류 유충에 관한 연구

김영길,윤권식 한국어병학회 2003 한국어병학회지 Vol.16 No.3

해산 이매패류에서의 흡충류의 기생종과 병해를 조사 할 목적으로 2001년 4월부터 2002년 10월 사이에 우리나라 서해안 내륙지와 인접한 전북 고창의 부창만내 주진천의 일본재첩과 부안군 계화도의 가리맛조개, 그리고 육지로부터 멀리 떨어져 있는 어청도와 말도 및 개야도에서 채집한 바지락을 조사하였다. 일본재첩에서는 조개내의 생식소에서 한국산 미 기록종인 Cercaria corbiculae가 검출되었는데, 그 크기는 278×98㎛, sporocy는 890×275㎛이었고, 0.83%의 낮은 기생율을 나타냈다. 계화도산 가리맛조개의 외투막에서 크기가 0.351×0.182 ㎜의 Parvatrema duboisi의 피낭 유충을 검출하였다. 가리맛조개는 이 종의 새로운 중간 숙주가 되며, 조개에서의 기생율은 48.3%이었고, 조개 1개당 1∼9마리가 기생되었으며, 수온과 조개의 크기에 따른 기생율에서는 큰 차이가 없었다. 어청도와 말도 및 개야도산 바지락에서 꼬리 긴 cercaria의 일종인 Cercaria tapidis가 조개의 생식소와 외투막에서 검출되었으며, 어청도산 바지락의 연평균 기생율은 7.7%, 기생율이 가장 높은 달은 수온 11℃인 12월에 16.7%, 가장 낮은 달은 수옥 19℃인 7월에 4.8%로 육지와 접한 금강하구의 솔리산 바지락에서의 연평균 기생율 (5.75%)이나 월별 기생율이 오히려 내륙과 연결된 간석지산 바지락 보다 약간 높았다. 바지락의 크기별 기생율은 각장 3.6∼4.0㎝가 48.3%로 가장 높은 기생율을 나타낸 반면, 각장 4∼5㎝의 큰 조개에서는 0.8%의 낮은 기생율을 나타냈다. The present study was conducted to research some parastic trematodes species in marine bivalves which are widely distributed in the western sea in Korea. From April, 2001 to October, 2002, marsh calm (Corbicula japonica) were obtained from Kochang bay near the Sunun temple and razor calm (Sinonovaculla constricta) from Kaehwado. Short necked calm (Ruditupes philippnurum) were sampled from Ochungdo, Mardo and Kaeyado. Cercariu corhiculae was found in the gonad of C. juponica with a low infection rate of 0.83%. The cercaria and the sporocyst were sized 278 × 98㎛ and 890X275um, respectively. Some encysted larvae of Parvatrema duhoisi sized 0.351 × 0.182㎛ were firstly found in the mantle of S. constricta in Korea. Each S. constrictu contained 1-9 cysts and the infection rate was 48.3%. Cercuriu tupidis was found in the both gonad and mantle of R. philippinurum. The annual average infection rate in the R. philippinurum from Ochungdo was 7.7%. This rate was much higher than those From Solri near the Kum river estuary in 1981. The infection rate of C. tupidis in R. philippinurum was different in sizes. The maximum rate was 4.8% in size 3.6 × 4.0㎝ and the minimum rate 0.8% in size 4-5㎝.

韓國人의 各 臟器組織中 靑酸鹽의 微量分布에 關한 硏究(Ⅱ)

張成吉,金恩浩,金英雲,李鎭勳,柳在薰,權五星,金明德,吳世珍,金由那 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

A. 高校 科學 (生物·地球科學) 및 數學科 探究學習의 評價模型 定立과 評價紙 開發

李相協,權炳奎,林在圭,孫文求,吳岱燮,楊洪準,梁承榮,姜用熙,林成圭,金正遠,金吉民,兪正在 경북대학교 과학교육연구소 1982 科學敎育硏究誌 Vol.6 No.-

Currently the evaluation of high school science and mathematics learning has been too much knowledge-centered without concerning the inquiring ability or scientific attitude. This study, therefore, was made for the purpose of establishing of evaluation model for high school science (biology and earth science) and mathematics learning and its evaluation items. In this paper, the research was done about three fields, biology, earth science and mathematics. 1. For the biology, the evaluation methods of inquiry learning were studied with the foreign references, and proper evaluation items were suggested. 2. For the earth science, after analizing 5 kinds of earth science textbook of current using in high school, essential 19 items were selected. 5 of them were tested in test group and control group, then, the results were analized. 3. For the mathematice, the teaching elements of「Set」and「Flow chart」in mathematics (Ⅰ) were selected and structured. Detailed teaching objects were established and evaluation items were introduced.

複合的商業스포츠施設의 利用實態와 運營實際上의 問題點과 課題 : 大邱市 地域을 中心으로

李來華,金永煥,申榮吉,李秀川,朴炫權 慶北大學校 體育科學硏究所 1991 체육과학연구지 Vol.7 No.-

In Conclusion, it is demanded that we throw away a fixed idea that commercial sports facilities are inferior and that we think its desirable direction of development and prepare a positive policy for it as a social physical education sports facility. We ought to not control it by using the laws of merrymaking businesses but consider the way to guide, assist, and encourage it at a dimension of Physical education development from seperate point of view as stated above. It Plays roles to replenish the shortage of public sports facilities especially in our country, So we first evaluate its roles to be being carried out and its performance limit properly and need to grasp newly the roles of public, private and commercial physical education and sports facilities in the whole organization of social physical education. While the national interests and demands in sports are being expended and accelerated nowadays, if commerical sports facilites are negleated in the contempt and indifference in the actual situation of these days, witout the reasonable conversion of conciousness of the people in the administration authorities about this or the propulsion of constrution of public facilities, the menbership free of menbers using facilities will inevitably soar, the approach of most general public enjoying sports to these facilities will be more difficults, and the alienated people from sports facilites may diffuse the conflict and stress caused by a remarkable contrast of the wealth of money by doing various kinds of antisocial and unadaptable behavior and by drinking too much enough to injure health. These make sports for participating and acting disappear and make sport for just hearing and Watching. This was happended severely in the past and it turns away the essence of soprts while the former is a conflict among castes caused by the superiority and inferiority of sports technics, but a phenomenon of these days is a conflict among castes caused by the distinction of the wealth of maney. This promotes the feelings of distance among people and misleads the vigor of living sports, the sports of our life.