Validation of the Korean version of the thyroid cancerspecific quality of life questionnaire

Youjin Jeong,Jaekyung Choi,Ah-Leum Ahn,Eun-Jung Oh,Hee-Kyung Oh,Dong-Yung Cho,Hyuk-Jung Kweon,Kyoung Sik Park 대한외과학회 2015 Annals of Surgical Treatment and Research(ASRT) Vol.89 No.6

Purpose: The increasing incidence of thyroid cancer worldwide has drawn attention to the needs for assessing and managing health-related quality of life (HRQoL) of thyroid cancer survivors. We conducted this study to validate the Korean version of the thyroid cancer-specific quality of life (THYCA-QoL) questionnaire. Methods: Data obtained from 227 thyroid cancer survivors were analyzed using standard validity and reliability analysis techniques. Reliability was assessed by measuring internal consistency via Cronbach α coefficient, and validity was assessed by determining the Pearson correlation coefficient between the THYCA-QoL questionnaire and the following relevant assessment tools: the European Organization for Research and Treatment of Cancer QLQ-C30 (EORTC QLQ-C30), the Korean version of Brief Fatigue Inventory (BFI-K), the Korean version of Brief Encounter Psychosocial Instrument (BEPSI-K), Goldberg Short Screening Scale for Anxiety and Depression, and a nine-item Patient Health Questionnaire (PHQ-9). A multitrait scaling analysis was performed to assess each item’s convergent and discriminant validity. Results: The reliability of the THYCA-QoL questionnaire was confirmed by Cronbach α coefficients for multiple-item scales which ranged from 0.54 (sensory) to 0.82 (psychological). Except for a single item (sexual interest), the questionnaire’s validity was established by significant correlation observed between scales in the THYCA-QoL questionnaire and scales used in other assessment tools. A multitrait scaling analysis confirmed that all scales met the recommended psychometric standards. Conclusion: The Korean version of the THYCA-QoL questionnaire is a reliable and valid assessment tool that can be used in combination with the EORTC QLQ-C30 to assess the HRQoL of thyroid cancer survivors in Korea.

Enzymatic synthesis and biochemical characterization of rubusoside glucoside using dextransucrase

Youjin JUNG,Nguyen Thi Thanh HANH,Sanjida HUMAYUN,Juhui JIN,Doman KIM 한국생물공학회 2019 한국생물공학회 학술대회 Vol.2019 No.10

A Case of Overlap Syndrome of Systemic Sclerosis and Cryoglobulinemic Vasculitis With Central Nervous System Involvement

( Youjin Jung ),( Eunyoung Emily Lee ),( Jina Yeo ),( Mi Hyeon Kim ),( Se Rim Choi ),( Yeong Wook Song ) 대한류마티스학회 2021 대한류마티스학회지 Vol.28 No.4

Mixed cryoglobulinemic vasculitis (CV) is occasionally caused by autoimmune diseases including systemic sclerosis. Multiorgan involvement such as skin, kidney, and peripheral nerve involvement is common in mixed CV. However, central nervous system (CNS) involvement is extremely rare. Here, we report a case of overlap syndrome of limited cutaneous systemic sclerosis and mixed cryoglobulinemic vasculitis with CNS involvement. The neurologic deficits and systemic symptoms improved promptly after steroid and cyclophosphamide therapy. (J Rheum Dis 2021;28:242-246)

Modulating cellular balance of Rps3 mono-ubiquitination by both Hel2 E3 ligase and Ubp3 deubiquitinase regulates protein quality control

Jung, Youjin,Kim, Hag Dong,Yang, Hee Woong,Kim, Hye Jin,Jang, Chang-Young,Kim, Joon Nature Publishing Group 2017 Experimental and molecular medicine Vol.49 No.11

<P>When a ribosome complex is stalled during the translation elongation process in eukaryotes, the mono-ubiquitination of Rps3 has recently been shown to be critical to ribosome quality control. We have discovered that the regulatory role of Rps3 mono-ubiquitination is controlled by a deubiquitinase. We also showed that an autophagic signal appears to be coupled to the mono-ubiquitination of Rps3p through the entrance of Ubp3p into the autophagosome in yeasts. The mono-ubiquitination of the Rps3 protein is tightly modulated by reciprocal action between the Hel2p E3 ligase and the Ubp3p deubiquitinase in yeasts and the reciprocal action between the RNF123 E3 ligase and the USP10 deubiquitinase in mammalian cells. We also found that the Ubp3p/USP10 deubiquitinases critically modulate Hel2p/RNF123-mediated Rps3p mono-ubiquitination. In addition, we found that Hel2p/RNF123 and Ubp3p/USP10 appeared to be differently localized in the ribosome complex after ultraviolet irradiation. Together, our results support a model in which coordinated ubiquitination and deubiquitination activities can finely balance the level of regulatory Rps3p mono-ubiquitination in ribosome-associated quality control and autophagy processes.</P>

cardiovascular health in overweight or obese postmenopausal women

Youjin Jung,Nah-Mee Shin 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10

Aim(s): The aim of this study was to examine the effects of a Home-based Lifestyle Intervention (HoLi) on cardiovascular health in the middle-aged women at risk of progressing to cardiovascular disease (CVD). Method(s): This quasi-experimental study used a non-equivalent control group pretest and posttest design and intervention program was based on the Information-Motivation-Behavioral Skills model. The HoLi program demonstrated that exercise and diet can be practiced at home for postmenopausal women who have major risk factors for CVD. This 6-week program consisted of brisk walking, DASH (Dietary Approaches to Stop Hypertension) diet, individual education, tailored counseling, self-monitoring using a smart band and a diary. A total 45 subjects were divided into two groups, 21 to intervention group and 24 to control group. The data were analyzed by descriptive statistics, χ2-test, Fisher’s exact test, independent t-test, Mann-Whitney U test, ranked ANCOVA were utilized using SPSS program (ver. 25). Result(s): Overall, intervention group significantly improved in the CVD prevention knowledge, self-efficacy (exercise, diet), CVD prevention health behavior, body weight, body mass index, body fat percentage, waist circumference, total cholesterol, LDL-cholesterol, fasting blood glucose and systolic blood pressure (BP) compared to the control group. However, there were no significant differences between groups in the triglycerides, HDL-cholesterol, and diastolic BP. Conclusion(s): The results suggested that the home-based lifestyle intervention for cardiovascular health in overweight or obese postmenopausal women was effective in improving their knowledge, self-efficacy, health behaviors, anthropometric indicators, lipid profile, and cardiovascular risk. Therefore lifestyle intervention program targeting modifiable cardiovascular risk factors might be an effective strategy if offered with tailored approach and concentrated support for them to adhere to the program.

천식 아동 및 청소년에서 원격모니터링 중재의 효과 : 체계적 문헌고찰 및 메타분석

정유진(Jung, Youjin),김지민(Kim, Jimin),박동아(Park, Dong Ah) 한국간호과학회 2018 Journal of Korean Academy of Nursing Vol.48 No.4

Purpose: This review aimed to evaluate the effectiveness of telemonitoring (TM) in the management of children and adolescents with asthma. Methods: We searched Ovid-MEDLINE, Ovid-EMBASE, CENTRAL (Cochrane Central Register of Controlled Trials), CINAHL (Cumulative Index to Nursing and Allied Health Literature), and 5 domestic databases to identify randomized controlled trials (RCTs) published through December 2017. Two reviewers independently selected relevant studies, assessed methodological quality and extracted data. We performed a meta-analysis of TM versus usual care and summarized the intervention characteristics of included studies. Results: Of the 3,095 articles identified, 8 RCTs (9 articles) were included in this review. The type of TM intervention of included studies was varying across studies (transmitted data, transmission frequency, data review, etc.). The pooled asthma control score was not significantly different between TM and usual care (standardized mean difference 0.04, 95% confidence interval (CI) -0.20~0.28). Another pooled analysis demonstrated no statistically significant difference in asthma exacerbation between TM and usual care (odds ratio 0.95, 95% CI 0.43~2.09). Overall, the pooled results from these studies revealed that TM did not lead to clinically significant improvements in health outcomes, but some studies in our analysis suggested that TM increased patient medication adherence and intervention adherence. Conclusion: The current evidence base does not demonstrate any differences between TM intervention and usual care, but TM intervention might be considered a promising strategy for the delivery of self-management support for children and adolescents with asthma. Further well-designed studies are needed to assess the effects on clinical outcomes.

유전자원 접근 및 이익공유(ABS) 유형 구분 및 특성 분석

정유진(Youjin Jung),최태헌(Taeheon Choi),김준순(Joonsoon Kim),박민영(Minyoung Park) 한국환경정책학회 2018 環境政策 Vol.26 No.4

대학생의 학습공동체 참여에서 나타나는 자기조절학습의 인식연결망 분석(ENA)

정유진 ( Youjin Jung ),박하나 ( Hana Park ),이주원 ( Juwon Lee ),임규연 ( Kyu Yon Lim ) 한국교육정보미디어학회 2022 교육정보미디어연구 Vol.28 No.3

본 연구는 학습공동체의 협력과정에서 인지조절과 정서조절이 어떻게 나타나는지 확인하고, 시간에 따라 어떻게 변화하는지 탐색하였다. 본 연구를 위하여 수도권 A대학에서 2021학년도 2학기에 운영하였던 학습공동체에 참여한 7개의 그룹 중 3개 그룹이 연구에 참여하였다. 3개 그룹은 학습활동 전반부, 중반부, 후반부에 걸쳐 온라인으로 학습하는 과정을 영상으로 녹화하였다. 결과 분석을 위해 녹화영상에서 학습자가 나눈 대화를 전사하고, 인지조절(계획, 모니터링, 평가)과 정서조절(모니터링, 조절)의 5개 요인을 코딩 후 인식연결망 분석을 실시하였다. 연구 결과, 학습공동체마다 다른 특징의 연결망을 확인할 수 있었다. 교과 학습의 높은 성취를 목표로 학습하는 그룹 A는 인지조절 모니터링을 중심으로 정서의 조절과 동시출현하는 비중이 높은 것으로 나타났으며, 창업 기획안의 공모전 당선을 목표로 학습하는 그룹 B는 인지조절의 모니터링을 중심으로 정서의 조절, 인지의 계획과의 동시출현 가중치가 높게 나타나고 있음을 확인하였다. 구체적 산출물인 영상 제작을 목표로 하는 그룹 C에서는 인지조절 모니터링을 중심으로 인지의 계획, 평가와의 동시출현의 가중치가 높게 나타났다. 그 다음으로, 시간에 따른 정서조절과 인지조절의 변화를 확인하였는데, 각 그룹마다 학습이 진행되는 과정에서 동시출현의 연결망이 변화하는 것을 확인하였다. 본 연구에서는 인식연결망 분석을 활용하여 담화분석에서 나타나는 정서조절과 인지조절 간 연결구조를 탐색하였다는 데 의의가 있으며, 정성적 데이터를 정량화하여 질적 탐색결과를 보완할 수 있는 연구방법을 활용하여 보다 설득력있는 탐색 결과를 도출하였다는데 의의가 있다. This study aimed to investigate cognitive and emotional regulation occurring in the learning community and explore changes in regulation over time. For this study, the conversations of three teams who participated in the learning community program of A university were recorded at the beginning, middle, and end of the online learning process. The discourse was coded for cognitive regulation (planning, monitoring, evaluation) and emotional regulation(monitoring, control), and analyzed with Epistemic Network Analysis. The results showed that each learning community had a different network in terms of regulations. Group A, which aimed to get a high achievement, showed a high weight of co-occurrence between monitoring of cognitive regulation and control of emotional regulation. Group B, which created a start-up plan for winning the contest, revealed a high weight of co-occurrence between monitoring of cognitive regulation and control of emotional regulation. Group C, which produced a specific video, showed a high weight of co-occurrence between the monitoring, planning, and evaluation of cognitive regulation. Second, the network of each learning community changed differently over time. This study explored the connection structures of regulatory behaviors using epistemic network analysis, which derived more persuasive results by quantifying and visualizing the qualitative data.

Projection of Cancer Incidence and Mortality From 2020 to 2035 in the Korean Population Aged 20 Years and Older

Youjin Hong,Sangjun Lee,Sungji Moon,Soseul Sung,Woojin Lim,Kyungsik Kim,Seokyung An,Jeoungbin Choi,Kwang-Pil Ko,Inah Kim,Jung Eun Lee,Sue K. Park 대한예방의학회 2022 예방의학회지 Vol.55 No.6

Objectives: This study aimed to identify the current patterns of cancer incidence and estimate the projected cancer incidence and mortality between 2020 and 2035 in Korea. Methods: Data on cancer incidence cases were extracted from the Korean Statistical Information Service from 2000 to 2017, and data on cancer-related deaths were extracted from the National Cancer Center from 2000 to 2018. Cancer cases and deaths were classified according to the International Classification of Diseases, 10th edition. For the current patterns of cancer incidence, age-standardized incidence rates (ASIRs) and age-standardized mortality rates were investigated using the 2000 mid-year estimated population aged over 20 years and older. A joinpoint regression model was used to determine the 2020 to 2035 trends in cancer. Results: Overall, cancer cases were predicted to increase from 265 299 in 2020 to 474 085 in 2035 (growth rate: 1.8%). The greatest increase in the ASIR was projected for prostate cancer among male (7.84 vs. 189.53 per 100 000 people) and breast cancer among female (34.17 vs. 238.45 per 100 000 people) from 2000 to 2035. Overall cancer deaths were projected to increase from 81 717 in 2020 to 95 845 in 2035 (average annual growth rate: 1.2%). Although most cancer mortality rates were projected to decrease, those of breast, pancreatic, and ovarian cancer among female were projected to increase until 2035. Conclusions: These up-to-date projections of cancer incidence and mortality in the Korean population may be a significant resource for implementing cancer-related regulations or developing cancer treatments.

Exertional Rhabdomyolysis after Spinning

Youjin Jeong,권혁중,Eun-Jung Oh,Ah-Leum Ahn,최재경,조동영 대한가정의학회 2016 Korean Journal of Family Medicine Vol.37 No.6

Any strenuous muscular exercise may trigger rhabdomyolysis. We report an episode of clinically manifested exer-tional rhabdomyolysis due to stationary cycling, commonly known as spinning. Reports of spinning-related rhab-domyolysis are rare in the English literature, and the current case appears to be the first such case reported in South Korea. A previously healthy 21-year-old Asian woman presented with severe thigh pain and reddish-brown urinary discoloration 24–48 hours after attending a spinning class at a local gymnasium. Paired with key laboratory find-ings, her symptoms were suggestive of rhabdomyolysis. She required hospital admission to sustain renal function through fluid resuscitation therapy and fluid balance monitoring. Because exertional rhabdomyolysis may occur in any unfit but otherwise healthy individual who indulges in stationary cycling, the potential health risks of this activ-ity must be considered.